|
|
ENSP00000263046-D1
(Bos grunniens)
AP-2
|
TF Information |
|---|
| Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
| PF03299 (TF_AP-2) |
IPR013854 |
ENSP00000263046-D1 |
T011174_2.00 |
GigaDB (2015-Oct-22) |
| NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
| No direct experiments |
|
|
|
|
|
Motifs from related TFs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
Tfap2b
M00112_2.00 |
Mus musculus |
CCBSRGGSNW |
WNSCCYSVGG |
PBM
Badis et al.(2009)
Tcfap2b_3988
|
1.000
|
1.000
|
TFAP2B
M02753_2.00 |
Homo sapiens |
HSCCYBVRGGCD |
HGCCYBVRGGSD |
SELEX
Jolma et al.(2013)
TFAP2B_1
|
1.000
|
1.000
|
TFAP2B
M02754_2.00 |
Homo sapiens |
HGCCTSRGGCD |
HGCCYSAGGCD |
SELEX
Jolma et al.(2013)
TFAP2B_2
|
1.000
|
1.000
|
TFAP2B
M02755_2.00 |
Homo sapiens |
WGCCCYBVRGGCD |
HGCCYBVRGGGCW |
SELEX
Jolma et al.(2013)
TFAP2B_3
|
1.000
|
1.000
|
TFAP2B
M04046_2.00 |
Homo sapiens |
NSCCBNVGGSN |
NSCCBNVGGSN |
SELEX
Yin et al.(2017)
TFAP2B_eDBD_HT-SELEX
|
1.000
|
1.000
|
TFAP2B
M08701_2.00 |
Homo sapiens |
GSCYGVGGRV |
BYCCBCRGSC |
Misc
Kulakovskiy et al.(2013)
AP2B_HUMAN.H11MO.0.B
|
1.000
|
1.000
|
Tfap2b
M08705_2.00 |
Mus musculus |
GSCYGVGGRV |
BYCCBCRGSC |
Misc
Kulakovskiy et al.(2013)
AP2B_MOUSE.H11MO.0.B
|
1.000
|
1.000
|
TFAP2B
M09750_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AP2BETA_Q3
|
1.000
|
1.000
|
TFAP2B
M04047_2.00 |
Homo sapiens |
NSCCYNRGGSD |
HSCCYNRGGSN |
SELEX
Yin et al.(2017)
TFAP2B_eDBD_Methyl-HT-SELEX
|
1.000
|
1.000
|
Tfap2a
M00111_2.00 |
Mus musculus |
HSCCBNVRGS |
SCYBNVGGSD |
PBM
Badis et al.(2009)
Tcfap2a_2337
|
0.892
|
0.892
|
TFAP2A
M02762_2.00 |
Homo sapiens |
HGCCYBVRGGSD |
HSCCYBVRGGCD |
SELEX
Jolma et al.(2013)
TFAP2A_1
|
0.892
|
0.892
|
TFAP2A
M02763_2.00 |
Homo sapiens |
HGCCYSMGGCN |
NGCCKSRGGCD |
SELEX
Jolma et al.(2013)
TFAP2A_2
|
0.892
|
0.892
|
TFAP2A
M02764_2.00 |
Homo sapiens |
NSCCCBNVRGGSN |
NSCCYBNVGGGSN |
SELEX
Jolma et al.(2013)
TFAP2A_3
|
0.892
|
0.892
|
TFAP2A
M02765_2.00 |
Homo sapiens |
HGCCTSRGGCD |
HGCCYSAGGCD |
SELEX
Jolma et al.(2013)
TFAP2A_4
|
0.892
|
0.892
|
TFAP2A
M02766_2.00 |
Homo sapiens |
HGCCYBVRGGCD |
HGCCYBVRGGCD |
SELEX
Jolma et al.(2013)
TFAP2A_5
|
0.892
|
0.892
|
TFAP2A
M02767_2.00 |
Homo sapiens |
WGCCCYNVGGGCD |
HGCCCBNRGGGCW |
SELEX
Jolma et al.(2013)
TFAP2A_6
|
0.892
|
0.892
|
Tfap2a
M02768_2.00 |
Mus musculus |
HGCCYBVRGGCR |
YGCCYBVRGGCD |
SELEX
Jolma et al.(2013)
Tcfap2a_1
|
0.892
|
0.892
|
Tfap2a
M02769_2.00 |
Mus musculus |
HGCCTSRGGCD |
HGCCYSAGGCD |
SELEX
Jolma et al.(2013)
Tcfap2a_2
|
0.892
|
0.892
|
Tfap2a
M02770_2.00 |
Mus musculus |
WGCCCYBVGGGCD |
HGCCCBVRGGGCW |
SELEX
Jolma et al.(2013)
Tcfap2a_3
|
0.892
|
0.892
|
TFAP2A
M04054_2.00 |
Homo sapiens |
NGCCBSVGGCN |
NGCCBSVGGCN |
SELEX
Yin et al.(2017)
TFAP2A_FL_HT-SELEX
|
0.892
|
0.892
|
TFAP2A
M07784_2.00 |
Homo sapiens |
NBNSCCYSRGGSCWN |
NWGSCCYSRGGSNVN |
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_AP2ALPHA_UCD
|
0.892
|
0.892
|
TFAP2A
M08703_2.00 |
Homo sapiens |
NHDSCCYCAGGSHWN |
NWDSCCTGRGGSHDN |
Misc
Kulakovskiy et al.(2013)
AP2A_HUMAN.H11MO.0.A
|
0.892
|
0.892
|
Tfap2a
M08704_2.00 |
Mus musculus |
SCCYCRGGSNNN |
NNNSCCYGRGGS |
Misc
Kulakovskiy et al.(2013)
AP2A_MOUSE.H11MO.0.A
|
0.892
|
0.892
|
TFAP2A
M09755_2.00 |
Homo sapiens |
GCCBBVVGS |
SCBBVVGGC |
Transfac
Matys et al.(2006)
V$AP2ALPHA_01
|
0.892
|
0.892
|
TFAP2A
M09756_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AP2ALPHA_02
|
0.892
|
0.892
|
TFAP2A
M09757_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AP2ALPHA_03
|
0.892
|
0.892
|
TFAP2A
M09758_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AP2ALPHA_Q4
|
0.892
|
0.892
|
TFAP2A
M09759_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AP2ALPHA_Q6
|
0.892
|
0.892
|
TFAP2A
M09760_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$TFAP2A_09
|
0.892
|
0.892
|
TFAP2A
M04055_2.00 |
Homo sapiens |
NSCCTNAGGSN |
NSCCTNAGGSN |
SELEX
Yin et al.(2017)
TFAP2A_FL_Methyl-HT-SELEX
|
0.892
|
0.892
|
TFAP2E
M04050_2.00 |
Homo sapiens |
HSCCYSRGGSD |
HSCCYSRGGSD |
SELEX
Yin et al.(2017)
TFAP2E_FL_HT-SELEX_1
|
0.887
|
0.887
|
TFAP2E
M04051_2.00 |
Homo sapiens |
NSCCBBVGGSCA |
TGSCCBVVGGSN |
SELEX
Yin et al.(2017)
TFAP2E_FL_HT-SELEX_2
|
0.887
|
0.887
|
TFAP2E
M04052_2.00 |
Homo sapiens |
HSCCYSRGGSD |
HSCCYSRGGSD |
SELEX
Yin et al.(2017)
TFAP2E_FL_Methyl-HT-SELEX_1
|
0.887
|
0.887
|
TFAP2E
M04053_2.00 |
Homo sapiens |
NSCCYNRGGGCR |
YGCCCYNRGGSN |
SELEX
Yin et al.(2017)
TFAP2E_FL_Methyl-HT-SELEX_2
|
0.887
|
0.887
|
Tfap2e
M00114_2.00 |
Mus musculus |
NNGCCYBVGG |
CCBVRGGCNN |
PBM
Badis et al.(2009)
Tcfap2e_3713
|
0.882
|
0.882
|
Tfap2c
M00113_2.00 |
Mus musculus |
NSCCBBVGGS |
SCCBVVGGSN |
PBM
Badis et al.(2009)
Tcfap2c_2912
|
0.785
|
0.785
|
TFAP2C
M02756_2.00 |
Homo sapiens |
HSCCYBVRGGCD |
HGCCYBVRGGSD |
SELEX
Jolma et al.(2013)
TFAP2C_1
|
0.785
|
0.785
|
TFAP2C
M02757_2.00 |
Homo sapiens |
HGCCTBRGGCD |
HGCCYVAGGCD |
SELEX
Jolma et al.(2013)
TFAP2C_2
|
0.785
|
0.785
|
TFAP2C
M02758_2.00 |
Homo sapiens |
WGCCCYNRGGGCD |
HGCCCYNRGGGCW |
SELEX
Jolma et al.(2013)
TFAP2C_3
|
0.785
|
0.785
|
TFAP2C
M02759_2.00 |
Homo sapiens |
HSCCYBVRGGCD |
HGCCYBVRGGSD |
SELEX
Jolma et al.(2013)
TFAP2C_4
|
0.785
|
0.785
|
TFAP2C
M02760_2.00 |
Homo sapiens |
NGCCCBNVRGGCN |
NGCCYBNVGGGCN |
SELEX
Jolma et al.(2013)
TFAP2C_5
|
0.785
|
0.785
|
TFAP2C
M02761_2.00 |
Homo sapiens |
HGCCTBRGGCD |
HGCCYVAGGCD |
SELEX
Jolma et al.(2013)
TFAP2C_6
|
0.785
|
0.785
|
TFAP2C
M04048_2.00 |
Homo sapiens |
NSCYHNHRGBN |
NVCYDNDRGSN |
SELEX
Yin et al.(2017)
TFAP2C_eDBD_HT-SELEX
|
0.785
|
0.785
|
TFAP2C
M07783_2.00 |
Homo sapiens |
NSCCYSRGGSCANDN |
NHNTGSCCYSRGGSN |
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_AP2GAMMA_UCD
|
0.785
|
0.785
|
TFAP2C
M08702_2.00 |
Homo sapiens |
NDSCCYCAGGSHHN |
NDDSCCTGRGGSHN |
Misc
Kulakovskiy et al.(2013)
AP2C_HUMAN.H11MO.0.A
|
0.785
|
0.785
|
Tfap2c
M08706_2.00 |
Mus musculus |
NNSCCYGRGGSNN |
NNSCCYCRGGSNN |
Misc
Kulakovskiy et al.(2013)
AP2C_MOUSE.H11MO.0.A
|
0.785
|
0.785
|
TFAP2C
M09451_2.00 |
Homo sapiens |
SCCYSRGGSHNN |
NNDSCCYSRGGS |
Misc
Heinz et al.(2010)
MCF7-TFAP2C_GSE21234
|
0.785
|
0.785
|
TFAP2C
M09751_2.00 |
Homo sapiens |
GCCBBVRGS |
SCYBVVGGC |
Transfac
Matys et al.(2006)
V$AP2GAMMA_01
|
0.785
|
0.785
|
TFAP2C
M09752_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AP2GAMMA_Q4
|
0.785
|
0.785
|
TFAP2C
M09753_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AP2GAMMA_Q5_01
|
0.785
|
0.785
|
TFAP2C
M09754_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$AP2GAMMA_Q5
|
0.785
|
0.785
|
TFAP2C
M04049_2.00 |
Homo sapiens |
NSCCYNRGGSN |
NSCCYNRGGSN |
SELEX
Yin et al.(2017)
TFAP2C_eDBD_Methyl-HT-SELEX
|
0.785
|
0.785
|
AP-2
M03584_2.00 |
Drosophila melanogaster |
HGCCYSRGGCD |
HGCCYSRGGCD |
SELEX
Nitta et al.(2015)
AP-2_1
|
0.703
|
0.703
|
AP-2
M03585_2.00 |
Drosophila melanogaster |
HGCCYBVRGGCD |
HGCCYBVRGGCD |
SELEX
Nitta et al.(2015)
AP-2_2
|
0.703
|
0.703
|
AP-2
M03586_2.00 |
Drosophila melanogaster |
NSCCYBNVRGGCN |
NGCCYBNVRGGSN |
SELEX
Nitta et al.(2015)
AP-2_3
|
0.703
|
0.703
|
AP-2
M03587_2.00 |
Drosophila melanogaster |
HGCCYNRGGCD |
HGCCYNRGGCD |
SELEX
Nitta et al.(2015)
AP-2_4
|
0.703
|
0.703
|
AP-2
M03588_2.00 |
Drosophila melanogaster |
HSCCYBVRGGSD |
HSCCYBVRGGSD |
SELEX
Nitta et al.(2015)
AP-2_5
|
0.703
|
0.703
|
AP-2
M03589_2.00 |
Drosophila melanogaster |
HGCCYBNVRGGCD |
HGCCYBNVRGGCD |
SELEX
Nitta et al.(2015)
AP-2_6
|
0.703
|
0.703
|
| For this family, TFs with SR scores > 0.700 will likely have a similar motif |