CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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snap_masked-nMf.1.1.scaf31395-processed-gene-0.2
(
Meloidogyne floridensis
)
AP-2
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
PF03299 (TF_AP-2)
IPR013854
snap_masked-nMf.1.1.scaf31395-processed-gene-0.2
T011547_2.00
WormBase:ParaSite (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasing blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, May 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
AP-2
M03584_2.00
Drosophila melanogaster
HGCCYSRGGCD
HGCCYSRGGCD
SELEX
Nitta et al.(2015)
AP-2_1
0.786
0.786
AP-2
M03585_2.00
Drosophila melanogaster
HGCCYBVRGGCD
HGCCYBVRGGCD
SELEX
Nitta et al.(2015)
AP-2_2
0.786
0.786
AP-2
M03586_2.00
Drosophila melanogaster
NSCCYBNVRGGCN
NGCCYBNVRGGSN
SELEX
Nitta et al.(2015)
AP-2_3
0.786
0.786
AP-2
M03587_2.00
Drosophila melanogaster
HGCCYNRGGCD
HGCCYNRGGCD
SELEX
Nitta et al.(2015)
AP-2_4
0.786
0.786
AP-2
M03588_2.00
Drosophila melanogaster
HSCCYBVRGGSD
HSCCYBVRGGSD
SELEX
Nitta et al.(2015)
AP-2_5
0.786
0.786
AP-2
M03589_2.00
Drosophila melanogaster
HGCCYBNVRGGCD
HGCCYBNVRGGCD
SELEX
Nitta et al.(2015)
AP-2_6
0.786
0.786
Tfap2a
M00111_2.00
Mus musculus
HSCCBNVRGS
SCYBNVGGSD
PBM
Badis et al.(2009)
Tcfap2a_2337
0.762
0.762
Tfap2c
M00113_2.00
Mus musculus
NSCCBBVGGS
SCCBVVGGSN
PBM
Badis et al.(2009)
Tcfap2c_2912
0.762
0.762
TFAP2A
M02762_2.00
Homo sapiens
HGCCYBVRGGSD
HSCCYBVRGGCD
SELEX
Jolma et al.(2013)
TFAP2A_1
0.762
0.762
TFAP2A
M02763_2.00
Homo sapiens
HGCCYSMGGCN
NGCCKSRGGCD
SELEX
Jolma et al.(2013)
TFAP2A_2
0.762
0.762
TFAP2A
M02764_2.00
Homo sapiens
NSCCCBNVRGGSN
NSCCYBNVGGGSN
SELEX
Jolma et al.(2013)
TFAP2A_3
0.762
0.762
TFAP2A
M02765_2.00
Homo sapiens
HGCCTSRGGCD
HGCCYSAGGCD
SELEX
Jolma et al.(2013)
TFAP2A_4
0.762
0.762
TFAP2A
M02766_2.00
Homo sapiens
HGCCYBVRGGCD
HGCCYBVRGGCD
SELEX
Jolma et al.(2013)
TFAP2A_5
0.762
0.762
TFAP2A
M02767_2.00
Homo sapiens
WGCCCYNVGGGCD
HGCCCBNRGGGCW
SELEX
Jolma et al.(2013)
TFAP2A_6
0.762
0.762
TFAP2C
M02756_2.00
Homo sapiens
HSCCYBVRGGCD
HGCCYBVRGGSD
SELEX
Jolma et al.(2013)
TFAP2C_1
0.762
0.762
TFAP2C
M02757_2.00
Homo sapiens
HGCCTBRGGCD
HGCCYVAGGCD
SELEX
Jolma et al.(2013)
TFAP2C_2
0.762
0.762
TFAP2C
M02758_2.00
Homo sapiens
WGCCCYNRGGGCD
HGCCCYNRGGGCW
SELEX
Jolma et al.(2013)
TFAP2C_3
0.762
0.762
TFAP2C
M02759_2.00
Homo sapiens
HSCCYBVRGGCD
HGCCYBVRGGSD
SELEX
Jolma et al.(2013)
TFAP2C_4
0.762
0.762
TFAP2C
M02760_2.00
Homo sapiens
NGCCCBNVRGGCN
NGCCYBNVGGGCN
SELEX
Jolma et al.(2013)
TFAP2C_5
0.762
0.762
TFAP2C
M02761_2.00
Homo sapiens
HGCCTBRGGCD
HGCCYVAGGCD
SELEX
Jolma et al.(2013)
TFAP2C_6
0.762
0.762
Tfap2a
M02768_2.00
Mus musculus
HGCCYBVRGGCR
YGCCYBVRGGCD
SELEX
Jolma et al.(2013)
Tcfap2a_1
0.762
0.762
Tfap2a
M02769_2.00
Mus musculus
HGCCTSRGGCD
HGCCYSAGGCD
SELEX
Jolma et al.(2013)
Tcfap2a_2
0.762
0.762
Tfap2a
M02770_2.00
Mus musculus
WGCCCYBVGGGCD
HGCCCBVRGGGCW
SELEX
Jolma et al.(2013)
Tcfap2a_3
0.762
0.762
TFAP2A
M04054_2.00
Homo sapiens
NGCCBSVGGCN
NGCCBSVGGCN
SELEX
Yin et al.(2017)
TFAP2A_FL_HT-SELEX
0.762
0.762
TFAP2C
M04048_2.00
Homo sapiens
NSCYHNHRGBN
NVCYDNDRGSN
SELEX
Yin et al.(2017)
TFAP2C_eDBD_HT-SELEX
0.762
0.762
TFAP2A
M07784_2.00
Homo sapiens
NBNSCCYSRGGSCWN
NWGSCCYSRGGSNVN
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_AP2ALPHA_UCD
0.762
0.762
TFAP2C
M07783_2.00
Homo sapiens
NSCCYSRGGSCANDN
NHNTGSCCYSRGGSN
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_AP2GAMMA_UCD
0.762
0.762
TFAP2A
M08703_2.00
Homo sapiens
NHDSCCYCAGGSHWN
NWDSCCTGRGGSHDN
Misc
Kulakovskiy et al.(2013)
AP2A_HUMAN.H11MO.0.A
0.762
0.762
TFAP2C
M08702_2.00
Homo sapiens
NDSCCYCAGGSHHN
NDDSCCTGRGGSHN
Misc
Kulakovskiy et al.(2013)
AP2C_HUMAN.H11MO.0.A
0.762
0.762
Tfap2a
M08704_2.00
Mus musculus
SCCYCRGGSNNN
NNNSCCYGRGGS
Misc
Kulakovskiy et al.(2013)
AP2A_MOUSE.H11MO.0.A
0.762
0.762
Tfap2c
M08706_2.00
Mus musculus
NNSCCYGRGGSNN
NNSCCYCRGGSNN
Misc
Kulakovskiy et al.(2013)
AP2C_MOUSE.H11MO.0.A
0.762
0.762
TFAP2C
M09451_2.00
Homo sapiens
SCCYSRGGSHNN
NNDSCCYSRGGS
Misc
Heinz et al.(2010)
MCF7-TFAP2C_GSE21234
0.762
0.762
TFAP2A
M09755_2.00
Homo sapiens
GCCBBVVGS
SCBBVVGGC
Transfac
Matys et al.(2006)
V$AP2ALPHA_01
0.762
0.762
TFAP2A
M09756_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP2ALPHA_02
0.762
0.762
TFAP2A
M09757_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP2ALPHA_03
0.762
0.762
TFAP2A
M09758_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP2ALPHA_Q4
0.762
0.762
TFAP2A
M09759_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP2ALPHA_Q6
0.762
0.762
TFAP2C
M09751_2.00
Homo sapiens
GCCBBVRGS
SCYBVVGGC
Transfac
Matys et al.(2006)
V$AP2GAMMA_01
0.762
0.762
TFAP2C
M09752_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP2GAMMA_Q4
0.762
0.762
TFAP2C
M09753_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP2GAMMA_Q5_01
0.762
0.762
TFAP2C
M09754_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP2GAMMA_Q5
0.762
0.762
TFAP2A
M09760_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFAP2A_09
0.762
0.762
TFAP2A
M04055_2.00
Homo sapiens
NSCCTNAGGSN
NSCCTNAGGSN
SELEX
Yin et al.(2017)
TFAP2A_FL_Methyl-HT-SELEX
0.762
0.762
TFAP2C
M04049_2.00
Homo sapiens
NSCCYNRGGSN
NSCCYNRGGSN
SELEX
Yin et al.(2017)
TFAP2C_eDBD_Methyl-HT-SELEX
0.762
0.762
Tfap2b
M00112_2.00
Mus musculus
CCBSRGGSNW
WNSCCYSVGG
PBM
Badis et al.(2009)
Tcfap2b_3988
0.738
0.738
Tfap2e
M00114_2.00
Mus musculus
NNGCCYBVGG
CCBVRGGCNN
PBM
Badis et al.(2009)
Tcfap2e_3713
0.738
0.738
TFAP2B
M02753_2.00
Homo sapiens
HSCCYBVRGGCD
HGCCYBVRGGSD
SELEX
Jolma et al.(2013)
TFAP2B_1
0.738
0.738
TFAP2B
M02754_2.00
Homo sapiens
HGCCTSRGGCD
HGCCYSAGGCD
SELEX
Jolma et al.(2013)
TFAP2B_2
0.738
0.738
TFAP2B
M02755_2.00
Homo sapiens
WGCCCYBVRGGCD
HGCCYBVRGGGCW
SELEX
Jolma et al.(2013)
TFAP2B_3
0.738
0.738
TFAP2B
M04046_2.00
Homo sapiens
NSCCBNVGGSN
NSCCBNVGGSN
SELEX
Yin et al.(2017)
TFAP2B_eDBD_HT-SELEX
0.738
0.738
TFAP2E
M04050_2.00
Homo sapiens
HSCCYSRGGSD
HSCCYSRGGSD
SELEX
Yin et al.(2017)
TFAP2E_FL_HT-SELEX_1
0.738
0.738
TFAP2E
M04051_2.00
Homo sapiens
NSCCBBVGGSCA
TGSCCBVVGGSN
SELEX
Yin et al.(2017)
TFAP2E_FL_HT-SELEX_2
0.738
0.738
TFAP2B
M08701_2.00
Homo sapiens
GSCYGVGGRV
BYCCBCRGSC
Misc
Kulakovskiy et al.(2013)
AP2B_HUMAN.H11MO.0.B
0.738
0.738
Tfap2b
M08705_2.00
Mus musculus
GSCYGVGGRV
BYCCBCRGSC
Misc
Kulakovskiy et al.(2013)
AP2B_MOUSE.H11MO.0.B
0.738
0.738
TFAP2B
M09750_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP2BETA_Q3
0.738
0.738
TFAP2B
M04047_2.00
Homo sapiens
NSCCYNRGGSD
HSCCYNRGGSN
SELEX
Yin et al.(2017)
TFAP2B_eDBD_Methyl-HT-SELEX
0.738
0.738
TFAP2E
M04052_2.00
Homo sapiens
HSCCYSRGGSD
HSCCYSRGGSD
SELEX
Yin et al.(2017)
TFAP2E_FL_Methyl-HT-SELEX_1
0.738
0.738
TFAP2E
M04053_2.00
Homo sapiens
NSCCYNRGGGCR
YGCCCYNRGGSN
SELEX
Yin et al.(2017)
TFAP2E_FL_Methyl-HT-SELEX_2
0.738
0.738
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
snap_masked-nMf.1.1.scaf31395-processed-gene-0.2-mRNA-1
AP-2
67
110
ETYCTVPGRLTLLSNLKKYRVTIAEVQRRLSPPECLNASVLGGI
Links
Other
AP-2
family TFs
Other
Meloidogyne floridensis
TFs
418 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy