MYC (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000136997 T014210_1.02 Ensembl (2011-Oct-26) Link out
NCBI Gene Info:
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
MYC
M3070_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_01
(Direct)
MYC
M3071_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_02
(Direct)
MYC
M3072_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_Q6_01
(Direct)
MYC
M3586_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MYC_02
(Direct)
MYC
M3587_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MYC_03
(Direct)
MYC
M4532_1.02
Homo sapiens
CCACGTGSNB

VNSCACGTGG
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_CMYC_Stanford
(Direct)
MYC
M4558_1.02
Homo sapiens
VCCACGTGSNN

NNSCACGTGGB
ChIP-seq
Gerstein et al.(2012)
HepG2_CMYC_UT-A
(Direct)
MYC
M4609_1.02
Homo sapiens
NCCACGTGBNB

VNVCACGTGGN
ChIP-seq
Gerstein et al.(2012)
K562_CMYC_Stanford
(Direct)
MYC
M4610_1.02
Homo sapiens
VSCRCGTGBNB

VNVCACGYGSB
ChIP-seq
Gerstein et al.(2012)
K562_CMYC_UT-A
(Direct)
MYC
M4643_1.02
Homo sapiens
DSCACGTG

CACGTGSH
ChIP-seq
Gerstein et al.(2012)
MCF-7_CMYC_UT-A
(Direct)
MYC
M4645_1.02
Homo sapiens
NVMCACGTGSN

NSCACGTGKBN
ChIP-seq
Gerstein et al.(2012)
NB4_CMYC_Stanford
(Direct)
MYC
M6351_1.02
Homo sapiens
RCCACGTGSBN

NVSCACGTGGY
HocoMoco
Kulakovskiy et al.(2013)
MYC_f1
(Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
Myc
M1964_1.02
Mus musculus
MCAYGTGBHY

RDVCACRTGK
ChIP-seq
Mathelier et al.(2014)
MA0147.2
0.935
For this family, TFs with SR scores > 0.600 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000367207 bHLH 370 422
ENSP00000367207 bHLH 433 452

Links

Other bHLH family TFs
Other Homo sapiens TFs

0 Related TFs

">No related TF found