TF Information

ARNTL *(Bos taurus)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	ENSBTAG00000013029	T033078_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2014]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Arntl M01751_2.00	Mus musculus	NCACGTGAYN	NRTCACGTGN	PBM Weirauch et al.(2014) pTH5064	0.914	1.000
ARNTL M02787_2.00	Homo sapiens	GTCACGTGAC	GTCACGTGAC	SELEX Jolma et al.(2013) ARNTL_1	0.914	1.000
ARNTL M04124_2.00	Homo sapiens	RDCACGTGHN	NDCACGTGHY	SELEX Yin et al.(2017) ARNTL_eDBD_HT-SELEX	0.914	1.000
ARNTL M08725_2.00	Homo sapiens	NVDCACGTGBN	NVCACGTGHBN	Misc Kulakovskiy et al.(2013) BMAL1_HUMAN.H11MO.0.A	0.914	1.000
Arntl M08776_2.00	Mus musculus	VCACGTGMN	NKCACGTGB	Misc Kulakovskiy et al.(2013) BMAL1_MOUSE.H11MO.0.A	0.914	1.000
Arntl M09478_2.00	Mus musculus	CACGTGNN	NNCACGTG	Misc Heinz et al.(2010) Liver-Bmal1_GSE39860	0.914	1.000
Arntl M09889_2.00	Rattus norvegicus	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$BMAL1_01	0.914	1.000
ARNTL M09841_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$BMAL1_Q6	0.914	1.000
ARNTL M04125_2.00	Homo sapiens	NDCACRTGHY	RDCAYGTGHN	SELEX Yin et al.(2017) ARNTL_eDBD_Methyl-HT-SELEX	0.914	1.000
For this family, TFs with SR scores > 0.838* will likely have a similar motif*