hand2 (Danio rerio)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSDARG00000008305 T033631_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; determination of intestine left/right asymmetry; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and pectoral fin. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
HAND2
M04150_2.00
Homo sapiens
MACACCTGBD

HVCAGGTGTK
SELEX
Yin et al.(2017)
HAND2_eDBD_HT-SELEX
0.914 0.981
HAND2
M04151_2.00
Homo sapiens
MACACCTGYD

HRCAGGTGTK
SELEX
Yin et al.(2017)
HAND2_eDBD_Methyl-HT-SELEX
0.914 0.981
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000022921 bHLH 88 140

Links

Other bHLH family TFs
Other Danio rerio TFs

Invalid Input OrderBy

101 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action