TF Information

clocka *(Danio rerio)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	ENSDARG00000011703	T033637_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Contributes to DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including photoperiodism; primitive hemopoiesis; and regulation of gene expression. Part of CLOCK-BMAL transcription complex. Is active in chromatin. Is expressed in brain; head; ovary; and photoreceptor cell. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CLOCK (clock circadian regulator). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Clock M01735_2.00	Mus musculus	NNCAYRTGNN	NNCAYRTGNN	PBM Weirauch et al.(2014) pTH5056	0.914	0.922
CLOCK M02789_2.00	Homo sapiens	DACACGTGYH	DRCACGTGTH	SELEX Jolma et al.(2013) CLOCK_1	0.914	0.922
CLOCK M04129_2.00	Homo sapiens	NMCACGTGYN	NRCACGTGKN	SELEX Yin et al.(2017) CLOCK_eDBD_HT-SELEX	0.914	0.922
CLOCK M08728_2.00	Homo sapiens	DBBBCAYKTGNNHB	VDNNCAMRTGVVVH	Misc Kulakovskiy et al.(2013) CLOCK_HUMAN.H11MO.0.C	0.914	0.922
Clock M08760_2.00	Mus musculus	DBBBCAYKTGNNHB	VDNNCAMRTGVVVH	Misc Kulakovskiy et al.(2013) CLOCK_MOUSE.H11MO.0.C	0.914	0.922
Clock M09473_2.00	Mus musculus	CACGTGNN	NNCACGTG	Misc Heinz et al.(2010) Liver-Clock_GSE39860	0.914	0.922
CLOCK M09849_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$CLOCK_Q6	0.914	0.922
CLOCK M04130_2.00	Homo sapiens	NRCRCRTGBH	DVCAYGYGYN	SELEX Yin et al.(2017) CLOCK_eDBD_Methyl-HT-SELEX	0.914	0.922
For this family, TFs with SR scores > 0.838* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSDARP00000014377	bHLH	26	76	KRVSRNRSEKKRRDQFNVLIKELGTMLPGNTRKMDKSTILQKSIDFLRKHK
ENSDARP00000126787	bHLH	26	76	KRVSRNRSEKKRRDQFNVLIKELGTMLPGNTRKMDKSTILQKSIDFLRKHK

Links
Other bHLH family TFs
Other *Danio rerio* TFs

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78 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action