TF Information

hey2 *(Danio rerio)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	ENSDARG00000013441	T033638_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a positive effect on cardiac muscle cell proliferation. Acts upstream of or within circulatory system development and negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; hematopoietic system; mesoderm; and nervous system. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Hey2 M01722_2.00	Mus musculus	RCACGTGNN	NNCACGTGY	PBM Weirauch et al.(2014) pTH5102	0.914	1.000
HEY2 M02790_2.00	Homo sapiens	GRCACGTGNV	BNCACGTGYC	SELEX Jolma et al.(2013) HEY2_1	0.914	1.000
HEY2 M02791_2.00	Homo sapiens	GVCACGTGYN	NRCACGTGBC	SELEX Jolma et al.(2013) HEY2_2	0.914	1.000
HEY2 M04131_2.00	Homo sapiens	NVCRCGYGVN	NBCRCGYGBN	SELEX Yin et al.(2017) HEY2_eDBD_HT-SELEX	0.914	1.000
HEY2 M04133_2.00	Homo sapiens	NVCACGTGVN	NBCACGTGBN	SELEX Yin et al.(2017) HEY2_FL_HT-SELEX	0.914	1.000
HEY2 M04132_2.00	Homo sapiens	NVCRCGYRVN	NBYRCGYGBN	SELEX Yin et al.(2017) HEY2_eDBD_Methyl-HT-SELEX	0.914	1.000
HEY2 M04134_2.00	Homo sapiens	NVCRCGYGSN	NSCRCGYGBN	SELEX Yin et al.(2017) HEY2_FL_Methyl-HT-SELEX	0.914	1.000
For this family, TFs with SR scores > 0.838* will likely have a similar motif*