neurod1 (Danio rerio)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSDARG00000019566 T033653_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including endocrine pancreas development; negative regulation of Notch signaling pathway; and neuron differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including endoderm; nervous system; neural plate; neurogenic placode; and pancreatic system. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NEUROD1
M04148_2.00 		Homo sapiens
RMCATATGKYVNNNTAWTT
AAWTANNNBRMCATATGKY		 SELEX
Yin et al.(2017)
NEUROD1_FL_HT-SELEX 		0.894 0.942
NEUROD1
M08057_2.00 		Homo sapiens
NNVCAGATGGNNN
NNNCCATCTGBNN		 ChIP-seq
Mathelier et al.(2014)
MA1109.1 		0.894 0.942
NEUROD1
M08735_2.00 		Homo sapiens
RVCAGATGGY
RCCATCTGBY		 Misc
Kulakovskiy et al.(2013)
NDF1_HUMAN.H11MO.0.A 		0.894 0.942
Neurod1
M08764_2.00 		Mus musculus
RVCAGATGGY
RCCATCTGBY		 Misc
Kulakovskiy et al.(2013)
NDF1_MOUSE.H11MO.0.A 		0.894 0.942
Neurod1
M09474_2.00 		Mus musculus
RVCAGATGGY
RCCATCTGBY		 Misc
Heinz et al.(2010)
Islet-NeuroD1_GSE30298 		0.894 0.942
NEUROD1
M09873_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NEUROD_01 		0.894 0.942
NEUROD1
M09874_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NEUROD_02 		0.894 0.942
NEUROD1
M04149_2.00 		Homo sapiens
RVCATATGBYVYNBTAWTW
WAWTAVNRBRVCATATGBY		 SELEX
Yin et al.(2017)
NEUROD1_FL_Methyl-HT-SELEX 		0.894 0.942
NEUROD2
M02795_2.00 		Homo sapiens
RVCATATGKY
RMCATATGBY		 SELEX
Jolma et al.(2013)
NEUROD2_1 		0.859 0.904
NEUROD2
M04160_2.00 		Homo sapiens
RVCATATGKY
RMCATATGBY		 SELEX
Yin et al.(2017)
NEUROD2_FL_HT-SELEX 		0.859 0.904
NEUROD2
M08737_2.00 		Homo sapiens
RRCAGMTGG
CCAKCTGYY		 Misc
Kulakovskiy et al.(2013)
NDF2_HUMAN.H11MO.0.B 		0.859 0.904
Neurod2
M08770_2.00 		Mus musculus
RVCAGATGGB
VCCATCTGBY		 Misc
Kulakovskiy et al.(2013)
NDF2_MOUSE.H11MO.0.A 		0.859 0.904
NEUROD2
M04161_2.00 		Homo sapiens
RMCATATGBY
RVCATATGKY		 SELEX
Yin et al.(2017)
NEUROD2_FL_Methyl-HT-SELEX 		0.859 0.904
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000026490 bHLH 97 149
ENSDARP00000132736 bHLH 97 149

Links

Other bHLH family TFs
Other Danio rerio TFs

Invalid Input OrderBy

271 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action