MLXIPL (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000009950 T034243_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MLXIPL
M02772_2.00		 Homo sapiens
DNCACGTGHH
DDCACGTGNH		 SELEX
Jolma et al.(2013)
MLXIPL_1		 (Direct) (Direct)
MLXIPL
M09788_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CHREBP_Q6		 (Direct) (Direct)
MLXIPL
M09789_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CHREB_Q6_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000320886 bHLH 650 704
ENSP00000346629 bHLH 648 713
ENSP00000392636 bHLH 556 610
ENSP00000406296 bHLH 650 715
ENSP00000412330 bHLH 648 702

Links

Other bHLH family TFs
Other Homo sapiens TFs

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42 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action