CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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TFE3
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000068323
T034247_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
TFE3
M02773_2.00
Homo sapiens
VNCACGTGMY
RKCACGTGNB
SELEX
Jolma et al.(2013)
TFE3_1
(Direct)
(Direct)
TFE3
M04058_2.00
Homo sapiens
YVCACGTGAYN
NRTCACGTGBR
SELEX
Yin et al.(2017)
TFE3_eDBD_HT-SELEX
(Direct)
(Direct)
TFE3
M04059_2.00
Homo sapiens
NRTCACATGBB
VVCATGTGAYN
SELEX
Yin et al.(2017)
TFE3_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
TFE3
M08709_2.00
Homo sapiens
TCACGTGACH
DGTCACGTGA
Misc
Kulakovskiy et al.(2013)
TFE3_HUMAN.H11MO.0.B
(Direct)
(Direct)
TFE3
M09790_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFEA_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Tfe3
M01715_2.00
Mus musculus
NCDCRTGAYN
NRTCAYGHGN
PBM
Weirauch et al.(2014)
pTH5057
0.871
0.981
Tfe3
M05833_2.00
Mus musculus
CACGTGAY
RTCACGTG
SMiLE-seq
Isakova et al.(2017)
TFE3
0.871
0.981
Tfe3
M08743_2.00
Mus musculus
TCACGTGACH
DGTCACGTGA
Misc
Kulakovskiy et al.(2013)
TFE3_MOUSE.H11MO.0.A
0.871
0.981
Tfe3
M09884_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFEA_01
0.871
0.981
Mitf
M01741_2.00
Mus musculus
NCDCGTGAYN
NRTCACGHGN
PBM
Weirauch et al.(2014)
pTH5465
0.871
0.963
MITF
M08058_2.00
Homo sapiens
NNNDRTCACGTGAYHNNN
NNNDRTCACGTGAYHNNN
ChIP-seq
Mathelier et al.(2014)
MA0620.2
0.871
0.963
MITF
M08740_2.00
Homo sapiens
YCAYGTGACH
DGTCACRTGR
Misc
Kulakovskiy et al.(2013)
MITF_HUMAN.H11MO.0.A
0.871
0.963
Mitf
M08765_2.00
Mus musculus
BCHYGTGACY
RGTCACRDGV
Misc
Kulakovskiy et al.(2013)
MITF_MOUSE.H11MO.0.A
0.871
0.963
Mitf
M09475_2.00
Mus musculus
GTCACRWGVB
VBCWYGTGAC
Misc
Heinz et al.(2010)
MastCells-MITF_GSE48085
0.871
0.963
MITF
M09880_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MITF_Q4
0.871
0.963
MITF
M09881_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MITF_Q6
0.871
0.963
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000314129
bHLH
347
400
KKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQ
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
136 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy