MNT (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000070444 T034249_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MNT
M02774_2.00
Homo sapiens
NVCACGTGNH

DNCACGTGBN
SELEX
Jolma et al.(2013)
MNT_1
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Mnt
M01716_2.00
Mus musculus
NCACGTGNN

NNCACGTGN
PBM
Weirauch et al.(2014)
pTH4588
0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000174618 bHLH 221 272

Links

Other bHLH family TFs
Other Homo sapiens TFs

67 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action