TFAP4 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000090447 T034253_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TFAP4
M02776_2.00		 Homo sapiens
AWCAGCTGWY
RWCAGCTGWT		 SELEX
Jolma et al.(2013)
TFAP4_1		 (Direct) (Direct)
TFAP4
M02777_2.00		 Homo sapiens
AWCAGCTGWT
AWCAGCTGWT		 SELEX
Jolma et al.(2013)
TFAP4_2		 (Direct) (Direct)
TFAP4
M04066_2.00		 Homo sapiens
VHCAKVTGDB
VHCABMTGDB		 SELEX
Yin et al.(2017)
TFAP4_eDBD_HT-SELEX_1		 (Direct) (Direct)
TFAP4
M04067_2.00		 Homo sapiens
VWCAGCTGWB
VWCAGCTGWB		 SELEX
Yin et al.(2017)
TFAP4_eDBD_HT-SELEX_2		 (Direct) (Direct)
TFAP4
M04068_2.00		 Homo sapiens
DHCABMTGDN
NHCAKVTGDH		 SELEX
Yin et al.(2017)
TFAP4_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
TFAP4
M04069_2.00		 Homo sapiens
AWCAGCTGWT
AWCAGCTGWT		 SELEX
Yin et al.(2017)
TFAP4_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)
TFAP4
M04070_2.00		 Homo sapiens
RHCAYVTGDB
VHCABRTGDY		 SELEX
Yin et al.(2017)
TFAP4_FL_HT-SELEX_1		 (Direct) (Direct)
TFAP4
M04071_2.00		 Homo sapiens
VHCAGCTGDB
VHCAGCTGDB		 SELEX
Yin et al.(2017)
TFAP4_FL_HT-SELEX_2		 (Direct) (Direct)
TFAP4
M04072_2.00		 Homo sapiens
VHCABVTGDB
VHCABVTGDB		 SELEX
Yin et al.(2017)
TFAP4_FL_Methyl-HT-SELEX_1		 (Direct) (Direct)
TFAP4
M04073_2.00		 Homo sapiens
VHCAGCTGDB
VHCAGCTGDB		 SELEX
Yin et al.(2017)
TFAP4_FL_Methyl-HT-SELEX_2		 (Direct) (Direct)
TFAP4
M08712_2.00		 Homo sapiens
VMNCAGCTGR
YCAGCTGNKB		 Misc
Kulakovskiy et al.(2013)
TFAP4_HUMAN.H11MO.0.A		 (Direct) (Direct)
TFAP4
M09453_2.00		 Homo sapiens
NVHCAGCTGD
HCAGCTGDBN		 Misc
Heinz et al.(2010)
AML-Tfap4_GSE45738		 (Direct) (Direct)
TFAP4
M09802_2.00		 Homo sapiens
MNGNCHVCAGCTGDBBBW
WVVVHCAGCTGBDGNCNK		 Transfac
Matys et al.(2006)
V$AP4_01		 (Direct) (Direct)
TFAP4
M09803_2.00		 Homo sapiens
NNSAGCTGHB
VDCAGCTSNN		 Transfac
Matys et al.(2006)
V$AP4_Q5		 (Direct) (Direct)
TFAP4
M09804_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AP4_Q6_01		 (Direct) (Direct)
TFAP4
M09805_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AP4_Q6_02		 (Direct) (Direct)
TFAP4
M09806_2.00		 Homo sapiens
NVCAGCTGHB
VDCAGCTGBN		 Transfac
Matys et al.(2006)
V$AP4_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tfap4
M01717_2.00 		Mus musculus
VHCABVYGB
VCRBVTGDB		 PBM
Weirauch et al.(2014)
pTH5067 		0.724 1.000
crp
M03595_2.00 		Drosophila melanogaster
AACAGCTGWT
AWCAGCTGTT		 SELEX
Nitta et al.(2015)
crp_1 		0.843 0.808
crp
M05937_2.00 		Drosophila melanogaster
VAHCAGCTGAY
RTCAGCTGDWB		 B1H
Zhu et al.(2011)
crp_SANGER_10_FBgn0001994 		0.843 0.808
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000204517 bHLH 49 100
ENSP00000459390 bHLH 1 40

Links

Other bHLH family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

105 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action