HIF1A (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000100644 T034254_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
HIF1A
M08049_2.00
Homo sapiens
NBACGTGCNN

NNGCACGTVN
ChIP-seq
Mathelier et al.(2014)
MA1106.1
(Direct) (Direct)
HIF1A
M08713_2.00
Homo sapiens
VDACGTGM

KCACGTHB
Misc
Kulakovskiy et al.(2013)
HIF1A_HUMAN.H11MO.0.C
(Direct) (Direct)
HIF1A
M09454_2.00
Homo sapiens
KACGTGMN

NKCACGTM
Misc
Heinz et al.(2010)
MCF7-HIF1a_GSE28352
(Direct) (Direct)
HIF1A
M09807_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1A_Q3
(Direct) (Direct)
HIF1A
M09808_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1A_Q5
(Direct) (Direct)
HIF1A
M09809_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1A_Q6
(Direct) (Direct)
HIF1A
M09810_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1_Q3
(Direct) (Direct)
HIF1A
M09811_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1_Q5
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Hif1a
M08750_2.00
Mus musculus
VDACGTGM

KCACGTHB
Misc
Kulakovskiy et al.(2013)
HIF1A_MOUSE.H11MO.0.C
0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000323326 bHLH 18 69
ENSP00000338018 bHLH 22 77
ENSP00000378446 bHLH 23 78
ENSP00000437955 bHLH 46 101

Links

Other bHLH family TFs
Other Homo sapiens TFs

28 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
AAO72733 Xenopus laevis AAO72733 I 0.914
Hif1a Mus musculus ENSMUSG00000021109 D 0.914
ABF71072 Xenopus laevis ABF71072 I 0.914
hif1a Xenopus tropicalis XB-GENE-946622 I 0.914
AAI26006 Xenopus laevis AAI26006 I 0.914
ENSSHAG00000012129 Sarcophilus harrisii ENSSHAG00000012129 I 0.882
HIF1A Monodelphis domestica ENSMODG00000008760 I 0.882
ENSLOCG00000010146 Lepisosteus oculatus ENSLOCG00000010146 I 0.882
ENSAMXG00000019342 Astyanax mexicanus ENSAMXG00000019342 I 0.858
Cmyd_10008490 Chelonia mydas Cmyd_10008490 I 0.857
Brh_R012268 Buceros rhinoceros Brh_R012268 I 0.857
Gfo_R006824 Geospiza fortis Gfo_R006824 I 0.857
Ogr06281 Ophisaurus gracilis Ogr06281 I 0.857
Tal_R011146 Tyto alba Tal_R011146 I 0.857
Alligator_sinensis_CCG014229.1 Alligator sinensis Alligator_sinensis_CCG014229.1 I 0.857
ENSTNIG00000019821 Tetraodon nigroviridis ENSTNIG00000019821 I 0.857
ENSAPLG00000002715 Anas platyrhynchos ENSAPLG00000002715 I 0.857
ENSFALG00000003396 Ficedula albicollis ENSFALG00000003396 I 0.857
HIF1A Meleagris gallopavo ENSMGAG00000013552 I 0.857
Afo_R010338 Aptenodytes forsteri Afo_R010338 I 0.857
ENSPSIG00000010467 Pelodiscus sinensis ENSPSIG00000010467 I 0.857
Aan_R001655 Calypte anna Aan_R001655 I 0.857
HIF1A Anolis carolinensis ENSACAG00000016205 I 0.857
HIF1A Taeniopygia guttata ENSTGUG00000012978 I 0.857
HIF1A Gallus gallus ENSGALG00000011870 I 0.857
ENSORLG00000015698 Oryzias latipes ENSORLG00000015698 I 0.846
e_gw.35.150.1 Branchiostoma floridae e_gw.35.150.1 I 0.845
e_gw.35.42.1 Branchiostoma floridae e_gw.35.42.1 I 0.845