CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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HIF1A
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000100644
T034254_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HIF1A
M08049_2.00
Homo sapiens
NBACGTGCNN
NNGCACGTVN
ChIP-seq
Mathelier et al.(2014)
MA1106.1
(Direct)
(Direct)
HIF1A
M08713_2.00
Homo sapiens
VDACGTGM
KCACGTHB
Misc
Kulakovskiy et al.(2013)
HIF1A_HUMAN.H11MO.0.C
(Direct)
(Direct)
HIF1A
M09454_2.00
Homo sapiens
KACGTGMN
NKCACGTM
Misc
Heinz et al.(2010)
MCF7-HIF1a_GSE28352
(Direct)
(Direct)
HIF1A
M09807_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1A_Q3
(Direct)
(Direct)
HIF1A
M09808_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1A_Q5
(Direct)
(Direct)
HIF1A
M09809_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1A_Q6
(Direct)
(Direct)
HIF1A
M09810_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1_Q3
(Direct)
(Direct)
HIF1A
M09811_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HIF1_Q5
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hif1a
M08750_2.00
Mus musculus
VDACGTGM
KCACGTHB
Misc
Kulakovskiy et al.(2013)
HIF1A_MOUSE.H11MO.0.C
0.914
1.000
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000323326
bHLH
18
69
RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRV
ENSP00000338018
bHLH
22
77
SRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD
ENSP00000378446
bHLH
23
78
SRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD
ENSP00000437955
bHLH
46
101
SRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
28 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy