USF2 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000105698 T034257_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
USF2
M04076_2.00
Homo sapiens
NVCACGTGVCN

NGBCACGTGBN
SELEX
Yin et al.(2017)
USF2_eDBD_HT-SELEX
(Direct) (Direct)
USF2
M04077_2.00
Homo sapiens
VNCAYGTGACN

NGTCACRTGNB
SELEX
Yin et al.(2017)
USF2_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
USF2
M07785_2.00
Homo sapiens
NGTCACGTGRBSVVV

BBBSVYCACGTGACN
ChIP-seq
Gerstein et al.(2012)
GM12878_USF2_Stanford
(Direct) (Direct)
USF2
M07786_2.00
Homo sapiens
NVGTCACGTGRBSVVV

BBBSVYCACGTGACBN
ChIP-seq
Gerstein et al.(2012)
H1-hESC_USF2_Stanford
(Direct) (Direct)
USF2
M07787_2.00
Homo sapiens
RGTCACGTGVB

VBCACGTGACY
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_USF2_Stanford
(Direct) (Direct)
USF2
M07788_2.00
Homo sapiens
NGTCACGTGRBSV

BSVYCACGTGACN
ChIP-seq
Gerstein et al.(2012)
HepG2_USF2_Stanford
(Direct) (Direct)
USF2
M07789_2.00
Homo sapiens
RGTCACGTGRBSV

BSVYCACGTGACY
ChIP-seq
Gerstein et al.(2012)
K562_USF2_Stanford
(Direct) (Direct)
USF2
M08050_2.00
Homo sapiens
NNVYCACGTGACHNNN

NNNDGTCACGTGRBNN
ChIP-seq
Mathelier et al.(2014)
MA0526.2
(Direct) (Direct)
USF2
M08715_2.00
Homo sapiens
NVGTCACGTGVBSVNNVNB

VNBNNBSVBCACGTGACBN
Misc
Kulakovskiy et al.(2013)
USF2_HUMAN.H11MO.0.A
(Direct) (Direct)
USF2
M09812_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$USF2_01
(Direct) (Direct)
USF2
M09813_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$USF2_02
(Direct) (Direct)
USF2
M09814_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$USF2_Q6_01
(Direct) (Direct)
USF2
M09815_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$USF2_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Usf1
M01732_2.00
Mus musculus
NRYCACGTGNN

NNCACGTGRYN
PBM
Weirauch et al.(2014)
pTH4376
0.607 1.000
Usf2
M01752_2.00
Mus musculus
NNCACGTGAN

NTCACGTGNN
PBM
Weirauch et al.(2014)
pTH5265
0.607 1.000
USF1
M02792_2.00
Homo sapiens
RNCACGTGRY

RYCACGTGNY
SELEX
Jolma et al.(2013)
USF1_1
0.607 1.000
USF1
M04146_2.00
Homo sapiens
NVCACGTGVCN

NGBCACGTGBN
SELEX
Yin et al.(2017)
USF1_FL_HT-SELEX
0.607 1.000
USF1
M08056_2.00
Homo sapiens
RGTCACRTGVB

VBCAYGTGACY
ChIP-seq
Mathelier et al.(2014)
MA0093.2
0.607 1.000
USF1
M07807_2.00
Homo sapiens
VGTCACGTGRBSVVV

BBBSVYCACGTGACB
ChIP-seq
Gerstein et al.(2012)
A549_USF1_HudsonAlpha
0.607 1.000
USF1
M07808_2.00
Homo sapiens
VVGTCACGTGVBSVS

SBSVBCACGTGACBB
ChIP-seq
Gerstein et al.(2012)
GM12878_USF1_HudsonAlpha
0.607 1.000
USF1
M07809_2.00
Homo sapiens
RGTCACGTGVBSVNN

NNBSVBCACGTGACY
ChIP-seq
Gerstein et al.(2012)
H1-hESC_USF1_HudsonAlpha
0.607 1.000
USF1
M07810_2.00
Homo sapiens
VGTCACGTGRB

VYCACGTGACB
ChIP-seq
Gerstein et al.(2012)
HepG2_USF1_HudsonAlpha
0.607 1.000
Usf2
M08777_2.00
Mus musculus
NVGTCACGTGVBSVNNVNB

VNBNNBSVBCACGTGACBN
Misc
Kulakovskiy et al.(2013)
USF2_MOUSE.H11MO.0.A
0.871 0.981
Usf2
M09479_2.00
Mus musculus
NNCAYGTGVY

RBCACRTGNN
Misc
Heinz et al.(2010)
C2C12-Usf2_GSE36030
0.871 0.981
USF1
M07811_2.00
Homo sapiens
NVGTCACGTGVSSV

BSSBCACGTGACBN
ChIP-seq
Gerstein et al.(2012)
K562_USF1_HudsonAlpha
0.607 1.000
USF1
M08733_2.00
Homo sapiens
VGTCACGTGVBS

SVBCACGTGACB
Misc
Kulakovskiy et al.(2013)
USF1_HUMAN.H11MO.0.A
0.607 1.000
Usf1
M08756_2.00
Mus musculus
NNGTCACGTGVBS

SVBCACGTGACNN
Misc
Kulakovskiy et al.(2013)
USF1_MOUSE.H11MO.0.A
0.607 1.000
USF1
M09460_2.00
Homo sapiens
YCACGTGRBN

NVYCACGTGR
Misc
Heinz et al.(2010)
GM12878-Usf1_GSE32465
0.607 1.000
USF1
M09867_2.00
Homo sapiens
NNRYCACGTGRYNN

NNRYCACGTGRYNN
Transfac
Matys et al.(2006)
V$USF_01
0.607 1.000
USF1
M09868_2.00
Homo sapiens
NNRNCAYRTGNYNN

NNRNCAYRTGNYNN
Transfac
Matys et al.(2006)
V$USF_02
0.607 1.000
USF1
M09869_2.00
Homo sapiens
HCACGTGH

DCACGTGD
Transfac
Matys et al.(2006)
V$USF_C
0.607 1.000
USF1
M04147_2.00
Homo sapiens
VHCAYGTGAYN

NRTCACRTGDB
SELEX
Yin et al.(2017)
USF1_FL_Methyl-HT-SELEX
0.607 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000222305 bHLH 236 291
ENSP00000340633 bHLH 169 224
ENSP00000368429 bHLH 105 160
ENSP00000469364 bHLH 92 198
ENSP00000470081 bHLH 41 96
ENSP00000471099 bHLH 236 283
ENSP00000471511 bHLH 234 289
ENSP00000471775 bHLH 114 143

Links

Other bHLH family TFs
Other Homo sapiens TFs

62 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSOARG00000004745 Ovis aries ENSOARG00000004745 I 0.914
USF2 Oryctolagus cuniculus ENSOCUG00000026259 I 0.914
USF2 Otolemur garnettii ENSOGAG00000001476 I 0.914
Usf2 Mus musculus ENSMUSG00000058239 D 0.914
ENSMPUG00000007099 Mustela putorius furo ENSMPUG00000007099 I 0.914
USF2 Microcebus murinus ENSMICG00000001519 I 0.914
USF2 Macaca mulatta ENSMMUG00000011291 I 0.914
ENSPANG00000011040 Papio anubis ENSPANG00000011040 I 0.914
USF2 Procavia capensis ENSPCAG00000013941 I 0.914
ENSSTOG00000022219 Ictidomys tridecemlineatus ENSSTOG00000022219 I 0.914
Alligator_sinensis_CCG004656.1 Alligator sinensis Alligator_sinensis_CCG004656.1 I 0.914
ENSP00000222305-D1 Bos grunniens ENSP00000222305-D1 I 0.914
USF2 Sus scrofa ENSSSCG00000002885 I 0.914
USF2 Pteropus vampyrus ENSPVAG00000004161 I 0.914
ENSPPYG00000009855 Pongo abelii ENSPPYG00000009855 I 0.914
USF2 Pan troglodytes ENSPTRG00000010836 I 0.914
USF2 Loxodonta africana ENSLAFG00000029360 I 0.914
ENSNLEG00000011114 Nomascus leucogenys ENSNLEG00000011114 I 0.914
USF2 Dasypus novemcinctus ENSDNOG00000003072 I 0.914
USF2 Felis catus ENSFCAG00000008894 I 0.914
ENSCSAG00000004521 Chlorocebus sabaeus ENSCSAG00000004521 I 0.914
USF2 Cavia porcellus ENSCPOG00000012147 I 0.914
USF2 Bos taurus ENSBTAG00000017035 I 0.914
USF2 Canis familiaris ENSCAFG00000007054 I 0.914
USF2 Equus caballus ENSECAG00000008583 I 0.914
ENSAMEG00000000235 Ailuropoda melanoleuca ENSAMEG00000000235 I 0.914
USF2 Callithrix jacchus ENSCJAG00000010451 I 0.903
ENSAMXG00000009564 Astyanax mexicanus ENSAMXG00000009564 I 0.889
usf2 Danio rerio ENSDARG00000020228 I 0.889
Pvit_11612 Pogona vitticeps Pvit_11612 I 0.889
ENSPSIG00000008600 Pelodiscus sinensis ENSPSIG00000008600 I 0.889
USF2 Takifugu rubripes ENSTRUG00000005182 I 0.889
ENSLACG00000003269 Latimeria chalumnae ENSLACG00000003269 I 0.889
USF2 Gasterosteus aculeatus ENSGACG00000012475 I 0.889
USF2 Oryzias latipes ENSORLG00000015114 I 0.889
USF2 Anolis carolinensis ENSACAG00000010293 I 0.889
Cmyd_10000422 Chelonia mydas Cmyd_10000422 I 0.889
ENSMLUG00000028063 Myotis lucifugus ENSMLUG00000028063 I 0.889
USF2 Monodelphis domestica ENSMODG00000013843 I 0.889
Myotis_brandtii_Usf2_10035177 Myotis brandtii Myotis_brandtii_Usf2_10035177 I 0.889
ENSGMOG00000013274 Gadus morhua ENSGMOG00000013274 I 0.889
Ogr06118 Ophisaurus gracilis Ogr06118 I 0.889
ENSLOCG00000005321 Lepisosteus oculatus ENSLOCG00000005321 I 0.889
usf2.S Xenopus laevis XB-GENE-6253011 I 0.886
usf1 Danio rerio ENSDARG00000041689 N 0.884
usf1 Takifugu rubripes ENSTRUG00000005343 I 0.876
usf1 Tetraodon nigroviridis ENSTNIG00000014361 I 0.876
usf1 Oryzias latipes ENSORLG00000015402 I 0.876
usf1 Gasterosteus aculeatus ENSGACG00000005115 I 0.876
Usf2 Rattus norvegicus ENSRNOG00000053725 I 0.871
USF1 Echinops telfairi ENSETEG00000015715 N 0.867
usf2.L Xenopus laevis XB-GENE-991248 I 0.861
ENSLACG00000001157 Latimeria chalumnae ENSLACG00000001157 I 0.858
ARNTL Homo sapiens ENSG00000133794 D 0.857
Myotis_brandtii_USF2_10034396 Myotis brandtii Myotis_brandtii_USF2_10034396 I 0.847
ENSPFOG00000005160 Poecilia formosa ENSPFOG00000005160 I 0.846
ENSONIG00000016360 Oreochromis niloticus ENSONIG00000016360 I 0.846
ENSGMOG00000009783 Gadus morhua ENSGMOG00000009783 I 0.846
ENSPFOG00000017027 Poecilia formosa ENSPFOG00000017027 I 0.846
ENSXMAG00000005137 Xiphophorus maculatus ENSXMAG00000005137 I 0.846
ENSXMAG00000006484 Xiphophorus maculatus ENSXMAG00000006484 I 0.846