MLX (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000108788 T034260_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MLX
M02779_2.00
Homo sapiens
RTCACGTGAY

RTCACGTGAY
SELEX
Jolma et al.(2013)
MLX_1
(Direct) (Direct)
MLX
M04080_2.00
Homo sapiens
NCACGTGN

NCACGTGN
SELEX
Yin et al.(2017)
MLX_eDBD_HT-SELEX
(Direct) (Direct)
MLX
M04081_2.00
Homo sapiens
NCACRTGV

BCAYGTGN
SELEX
Yin et al.(2017)
MLX_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
MLX
M04082_2.00
Homo sapiens
NVCACGTGVYN

NRBCACGTGBN
SELEX
Yin et al.(2017)
MLX_FL_HT-SELEX
(Direct) (Direct)
MLX
M04083_2.00
Homo sapiens
NDBCACRTGBV

BVCAYGTGVHN
SELEX
Yin et al.(2017)
MLX_FL_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Mlx
M00752_2.00
Mus musculus
CACGTGNNN

NNNCACGTG
PBM
Weirauch et al.(2013)
pTH2882
0.914 1.000
Mlx
M01721_2.00
Mus musculus
NCRCGTGNNN

NNNCACGYGN
PBM
Weirauch et al.(2014)
pTH5070
0.914 1.000
Mlx
M02815_2.00
Mus musculus
RTCACGTGAY

RTCACGTGAY
SELEX
Jolma et al.(2013)
Mlx_1
0.914 1.000
MLX
M01114_2.00
Monodelphis domestica
NNNCACGTGN

NCACGTGNNN
PBM
Lambert et al.(2019)
pTH11463
0.914 0.982
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000246912 bHLH 130 188
ENSP00000320913 bHLH 46 104
ENSP00000416627 bHLH 76 134
ENSP00000464697 bHLH 100 158

Links

Other bHLH family TFs
Other Homo sapiens TFs

52 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action