MLX (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000108788 T034260_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MLX
M02779_2.00
Homo sapiens
RTCACGTGAY

RTCACGTGAY
SELEX
Jolma et al.(2013)
MLX_1
(Direct) (Direct)
MLX
M04080_2.00
Homo sapiens
NCACGTGN

NCACGTGN
SELEX
Yin et al.(2017)
MLX_eDBD_HT-SELEX
(Direct) (Direct)
MLX
M04081_2.00
Homo sapiens
NCACRTGV

BCAYGTGN
SELEX
Yin et al.(2017)
MLX_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
MLX
M04082_2.00
Homo sapiens
NVCACGTGVYN

NRBCACGTGBN
SELEX
Yin et al.(2017)
MLX_FL_HT-SELEX
(Direct) (Direct)
MLX
M04083_2.00
Homo sapiens
NDBCACRTGBV

BVCAYGTGVHN
SELEX
Yin et al.(2017)
MLX_FL_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Mlx
M00752_2.00
Mus musculus
CACGTGNNN

NNNCACGTG
PBM
Weirauch et al.(2013)
pTH2882
0.914 1.000
Mlx
M01721_2.00
Mus musculus
NCRCGTGNNN

NNNCACGYGN
PBM
Weirauch et al.(2014)
pTH5070
0.914 1.000
Mlx
M02815_2.00
Mus musculus
RTCACGTGAY

RTCACGTGAY
SELEX
Jolma et al.(2013)
Mlx_1
0.914 1.000
MLX
M01114_2.00
Monodelphis domestica
NNNCACGTGN

NCACGTGNNN
PBM
Lambert et al.(2019)
pTH11463
0.914 0.982
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000246912 bHLH 130 188
ENSP00000320913 bHLH 46 104
ENSP00000416627 bHLH 76 134
ENSP00000464697 bHLH 100 158

Links

Other bHLH family TFs
Other Homo sapiens TFs

52 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
AT4G25400 Arabidopsis thaliana AT4G25400 D 0.000
Carubv10027166m.g Capsella rubella Carubv10027166m.g I 0.000
Carubv10006264m.g Capsella rubella Carubv10006264m.g I 0.000
Cagra.2248s0016 Capsella grandiflora Cagra.2248s0016 I 0.000
Cagra.0277s0021 Capsella grandiflora Cagra.0277s0021 I 0.000
Bostr.7867s0349 Boechera stricta Bostr.7867s0349 I 0.000
Bostr.15774s0324 Boechera stricta Bostr.15774s0324 I 0.000
Bostr.13671s0206 Boechera stricta Bostr.13671s0206 I 0.000
cassava45968.m1 Manihot esculenta cassava45968.m1 I 0.000
Ciclev10006628m.g Citrus clementina Ciclev10006628m.g I 0.000
Eucgr.F04119 Eucalyptus grandis Eucgr.F04119 I 0.000
LjSGA_023375.1 Lotus japonicus LjSGA_023375.1 I 0.000
PK15358.1 Cannabis sativa PK15358.1 I 0.000
PK11667.1 Cannabis sativa PK11667.1 I 0.000
Thhalv10026341m.g Eutrema salsugineum Thhalv10026341m.g I 0.000
Thhalv10015297m.g Eutrema salsugineum Thhalv10015297m.g I 0.000
Thhalv10009922m.g Eutrema salsugineum Thhalv10009922m.g I 0.000
orange1.1g036406m.g Citrus sinensis orange1.1g036406m.g I 0.000
MDP0000246258 Malus domestica MDP0000246258 I 0.000
cassava43207.valid.m1 Manihot esculenta cassava43207.valid.m1 I 0.000
cassava21379.m1 Manihot esculenta cassava21379.m1 I 0.000
AT5G51780 Arabidopsis thaliana AT5G51780 I 0.000
GLYMA09G27610 Glycine max GLYMA09G27610 I 0.000
Bra019167 Brassica rapa Bra019167 I 0.000
GLYMA16G32610 Glycine max GLYMA16G32610 I 0.000
Bo7g110280 Brassica oleracea Bo7g110280 I 0.000
POPTR_0012s14080 Populus trichocarpa POPTR_0012s14080 I 0.000
Solyc06g035490.2 Solanum lycopersicum Solyc06g035490.2 I 0.000
TCM_016133 Theobroma cacao TCM_016133 I 0.000
TCM_016134 Theobroma cacao TCM_016134 I 0.000
Ca_22233 Cicer arietinum Ca_22233 I 0.000
Bo2g048240 Brassica oleracea Bo2g048240 I 0.000
Pm019419 Prunus mume Pm019419 I 0.000
fgenesh2_kg.8__1059__AT5G51780.1 Arabidopsis lyrata fgenesh2_kg.8__1059__AT5G51780.1 I 0.000
Bo5g016800 Brassica oleracea Bo5g016800 N 0.000
Bra019773 Brassica rapa Bra019773 N 0.000
Lus10027394.g Linum usitatissimum Lus10027394.g N 0.000
Gorai.008G282400 Gossypium raimondii Gorai.008G282400 N 0.000
Ciclev10006639m.g Citrus clementina Ciclev10006639m.g N 0.000
Bo9g103560 Brassica oleracea Bo9g103560 N 0.000
MTR_1g102370 Medicago truncatula MTR_1g102370 N 0.000
TCM_015033 Theobroma cacao TCM_015033 N 0.000
Aquca_013_00494 Aquilegia coerulea Aquca_013_00494 N 0.000
30147.m014147 Ricinus communis 30147.m014147 N 0.000