SIM1 (Homo sapiens)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000112246 T034263_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000262901 bHLH 2 52
ENSP00000358210 bHLH 2 52


Other bHLH family TFs
Other Homo sapiens TFs

195 Related TFs

Name Species Gene ID Motif Evidence SR
AAEL011013 Aedes aegypti AAEL011013 I 0.838
AALB007758 Anopheles albimanus AALB007758 I 0.838
AALB007964 Anopheles albimanus AALB007964 I 0.838
Aan_R007307 Calypte anna Aan_R007307 N 0.862
Aan_R007898 Calypte anna Aan_R007898 N 0.914
AARA003714 Anopheles arabiensis AARA003714 I 0.838
AARA010261 Anopheles arabiensis AARA010261 N 0.862
AATE009363 Anopheles atroparvus AATE009363 I 0.838
ACHR009289 Anopheles christyi ACHR009289 N 0.862
ACOM023265 Anopheles coluzzii ACOM023265 I 0.838
ACOM027359 Anopheles coluzzii ACOM027359 I 0.838
ACOM042361 Anopheles coluzzii ACOM042361 N 0.862
ACUA010023 Anopheles culicifacies ACUA010023 N 0.862
ACUA025040 Anopheles culicifacies ACUA025040 I 0.838
ADAC005208 Anopheles darlingi ADAC005208 I 0.838
ADIR001121 Anopheles dirus ADIR001121 I 0.838
AEPI002639 Anopheles epiroticus AEPI002639 N 0.862
AFAF010850 Anopheles farauti AFAF010850 I 0.838
Afo_R003668 Aptenodytes forsteri Afo_R003668 N 0.914
Afo_R004895 Aptenodytes forsteri Afo_R004895 N 0.862
AFUN000102 Anopheles funestus AFUN000102 I 0.838
AFUN005600 Anopheles funestus AFUN005600 N 0.862
AGAP000773 Anopheles gambiae AGAP000773 N 0.862
AGAP010058 Anopheles gambiae AGAP010058 I 0.838
Alligator_sinensis_CCG004879.1 Alligator sinensis Alligator_sinensis_CCG004879.1 N 0.914
AMAM016994 Anopheles maculatus AMAM016994 N 0.862
AMEC013102 Anopheles melas AMEC013102 N 0.862
AMEC021622 Anopheles melas AMEC021622 I 0.838
AMEM005407 Anopheles merus AMEM005407 I 0.838
AMIN005129 Anopheles minimus AMIN005129 N 0.862
AMIN006671 Anopheles minimus AMIN006671 I 0.838
AQUA008255 Anopheles quadriannulatus AQUA008255 N 0.862
AQUA009218 Anopheles quadriannulatus AQUA009218 I 0.838
ASTEI03596 Anopheles stephensi ASTEI03596 N 0.862
ASTEI03921 Anopheles stephensi ASTEI03921 I 0.838
A_05788 Schistosoma haematobium A_05788 N 0.894
BGIBMGA003821 Bombyx mori BGIBMGA003821 I 0.838
Brh_R001528 Buceros rhinoceros Brh_R001528 N 0.914
CapteG165634 Capitella teleta CapteG165634 I 0.840
CGI_10023142 Crassostrea gigas CGI_10023142 N 0.862
Cmyd_10005300 Chelonia mydas Cmyd_10005300 N 0.862
Cmyd_10020168 Chelonia mydas Cmyd_10020168 N 0.914
CPIJ009948 Culex quinquefasciatus CPIJ009948 I 0.838
CpipJ_CPIJ009948 Culex pipiens CpipJ_CPIJ009948 I 0.838
csin104979 Clonorchis sinensis csin104979 N 0.894
D915_00831 Fasciola hepatica D915_00831 N 0.894
DAPPUDRAFT_311851 Daphnia pulex DAPPUDRAFT_311851 I 0.838
SIM2 Anolis carolinensis ENSACAG00000008765 N 0.862
SIM1 Anolis carolinensis ENSACAG00000010256 N 0.914
ENSAMEG00000005588 Ailuropoda melanoleuca ENSAMEG00000005588 N 0.862
ENSAMEG00000014765 Ailuropoda melanoleuca ENSAMEG00000014765 N 0.914
ENSAMXG00000001377 Astyanax mexicanus ENSAMXG00000001377 N 0.914
ENSAMXG00000008897 Astyanax mexicanus ENSAMXG00000008897 N 0.894
ENSAPLG00000012534 Anas platyrhynchos ENSAPLG00000012534 N 0.914
ENSAPLG00000014050 Anas platyrhynchos ENSAPLG00000014050 N 0.862
SIM1 Bos taurus ENSBTAG00000002294 N 0.914
SIM1 Canis familiaris ENSCAFG00000003538 N 0.914
SIM2 Canis familiaris ENSCAFG00000009686 N 0.862
SIM1 Choloepus hoffmanni ENSCHOG00000005099 N 0.914
SIM1 Callithrix jacchus ENSCJAG00000001495 N 0.914
SIM2 Callithrix jacchus ENSCJAG00000002704 N 0.862
SIM1 Cavia porcellus ENSCPOG00000013987 N 0.914
SIM2 Cavia porcellus ENSCPOG00000023156 N 0.862
ENSCSAG00000008567 Chlorocebus sabaeus ENSCSAG00000008567 N 0.862
ENSCSAG00000014652 Chlorocebus sabaeus ENSCSAG00000014652 N 0.914
sim1b Danio rerio ENSDARG00000013789 N 0.903
sim1a Danio rerio ENSDARG00000023316 N 0.914
SIM2 Dasypus novemcinctus ENSDNOG00000003669 N 0.862
SIM1 Dasypus novemcinctus ENSDNOG00000010261 N 0.914
ENSDORG00000008569 Dipodomys ordii ENSDORG00000008569 N 0.914
Sim2 Dipodomys ordii ENSDORG00000011548 N 0.862
SIM1 Equus caballus ENSECAG00000009161 N 0.914
SIM2 Equus caballus ENSECAG00000016631 N 0.862
SIM1 Erinaceus europaeus ENSEEUG00000009806 N 0.914
SIM1 Echinops telfairi ENSETEG00000010692 N 0.914
SIM2 Echinops telfairi ENSETEG00000012055 N 0.862
ENSFALG00000005247 Ficedula albicollis ENSFALG00000005247 N 0.914
SIM1 Felis catus ENSFCAG00000005942 N 0.914
SIM2 Felis catus ENSFCAG00000023063 N 0.862
SIM2 Homo sapiens ENSG00000159263 N 0.862
sim1b Gasterosteus aculeatus ENSGACG00000009479 N 0.914
sim1a Gasterosteus aculeatus ENSGACG00000014149 N 0.914
SIM1 Gallus gallus ENSGALG00000015466 N 0.914
SIM2 Gallus gallus ENSGALG00000016044 N 0.862
SIM2 Gorilla gorilla ENSGGOG00000014943 N 0.862
SIM1 Gorilla gorilla ENSGGOG00000017108 N 0.914
ENSGMOG00000006637 Gadus morhua ENSGMOG00000006637 N 0.914
ENSGMOG00000018211 Gadus morhua ENSGMOG00000018211 N 0.914
ENSLACG00000012873 Latimeria chalumnae ENSLACG00000012873 N 0.862
ENSLACG00000015924 Latimeria chalumnae ENSLACG00000015924 N 0.914
SIM2 Loxodonta africana ENSLAFG00000000122 N 0.862
SIM1 Loxodonta africana ENSLAFG00000006594 N 0.914
ENSLOCG00000005059 Lepisosteus oculatus ENSLOCG00000005059 N 0.862
ENSLOCG00000016561 Lepisosteus oculatus ENSLOCG00000016561 N 0.914
ENSMEUG00000000606 Macropus eugenii ENSMEUG00000000606 N 0.858
ENSMEUG00000011682 Macropus eugenii ENSMEUG00000011682 N 0.914
SIM1 Microcebus murinus ENSMICG00000008851 N 0.914
SIM2 Microcebus murinus ENSMICG00000013168 N 0.862
SIM1 Myotis lucifugus ENSMLUG00000002874 N 0.914
ENSMMUG00000015564 Macaca mulatta ENSMMUG00000015564 N 0.862
SIM1 Macaca mulatta ENSMMUG00000022285 N 0.914
NPAS1 Monodelphis domestica ENSMODG00000009053 N 0.858
SIM1 Monodelphis domestica ENSMODG00000018087 N 0.914
SIM2 Monodelphis domestica ENSMODG00000021008 N 0.862
ENSMPUG00000001668 Mustela putorius furo ENSMPUG00000001668 N 0.914
ENSMPUG00000008240 Mustela putorius furo ENSMPUG00000008240 N 0.862
Sim1 Mus musculus ENSMUSG00000019913 N 0.914
Sim2 Mus musculus ENSMUSG00000062713 N 0.862
ENSNLEG00000004481 Nomascus leucogenys ENSNLEG00000004481 N 0.862
ENSNLEG00000013870 Nomascus leucogenys ENSNLEG00000013870 N 0.914
SIM1 Ornithorhynchus anatinus ENSOANG00000008943 N 0.914
ENSOARG00000011739 Ovis aries ENSOARG00000011739 N 0.914
ENSOARG00000014072 Ovis aries ENSOARG00000014072 N 0.862
SIM1 Oryctolagus cuniculus ENSOCUG00000002759 N 0.914
SIM2 Oryctolagus cuniculus ENSOCUG00000012903 N 0.862
SIM1 Otolemur garnettii ENSOGAG00000009865 N 0.914
SIM2 Otolemur garnettii ENSOGAG00000028990 N 0.862
ENSONIG00000014696 Oreochromis niloticus ENSONIG00000014696 N 0.914
ENSONIG00000016544 Oreochromis niloticus ENSONIG00000016544 N 0.914
SIM1 Ochotona princeps ENSOPRG00000013168 N 0.914
ENSP00000262901 Macaca fascicularis ENSP00000262901 N 0.914
ENSP00000290399 Macaca fascicularis ENSP00000290399 N 0.862
ENSP00000290399-D1 Bos grunniens ENSP00000290399-D1 N 0.862
ENSP00000358210-D1 Bos grunniens ENSP00000358210-D1 N 0.914
ENSPANG00000011218 Papio anubis ENSPANG00000011218 N 0.914
ENSPANG00000020491 Papio anubis ENSPANG00000020491 N 0.862
SIM1 Procavia capensis ENSPCAG00000008763 N 0.914
SIM2 Procavia capensis ENSPCAG00000015289 N 0.862
ENSPFOG00000002603 Poecilia formosa ENSPFOG00000002603 N 0.882
ENSPPYG00000011405 Pongo abelii ENSPPYG00000011405 N 0.862
ENSPPYG00000016868 Pongo abelii ENSPPYG00000016868 N 0.914
ENSPSIG00000002579 Pelodiscus sinensis ENSPSIG00000002579 N 0.914
SIM2 Pan troglodytes ENSPTRG00000013894 N 0.862
SIM1 Pan troglodytes ENSPTRG00000018447 N 0.914
SIM2 Pteropus vampyrus ENSPVAG00000000853 N 0.862
SIM1 Pteropus vampyrus ENSPVAG00000012822 N 0.914
Sim1 Rattus norvegicus ENSRNOG00000037600 N 0.914
Sim2 Rattus norvegicus ENSRNOG00000054203 N 0.862
SIM1 Sorex araneus ENSSARG00000000736 N 0.914
ENSSHAG00000009425 Sarcophilus harrisii ENSSHAG00000009425 N 0.862
ENSSHAG00000016220 Sarcophilus harrisii ENSSHAG00000016220 N 0.914
SIM1 Sus scrofa ENSSSCG00000004357 N 0.914
ENSSTOG00000027359 Ictidomys tridecemlineatus ENSSTOG00000027359 N 0.914
SIM1 Tupaia belangeri ENSTBEG00000005949 N 0.914
SIM2 Tupaia belangeri ENSTBEG00000011573 N 0.862
SIM2 Taeniopygia guttata ENSTGUG00000004856 N 0.862
SIM1 Taeniopygia guttata ENSTGUG00000012278 N 0.914
sim1b Tetraodon nigroviridis ENSTNIG00000012304 N 0.914
ENSTNIG00000019722 Tetraodon nigroviridis ENSTNIG00000019722 N 0.914
SIM1 Takifugu rubripes ENSTRUG00000010040 N 0.903
sim1b Takifugu rubripes ENSTRUG00000018267 N 0.914
ENSTSYG00000005255 Tarsius syrichta ENSTSYG00000005255 N 0.862
ENSTSYG00000007116 Tarsius syrichta ENSTSYG00000007116 N 0.914
SIM1 Tursiops truncatus ENSTTRG00000008248 N 0.914
SIM2 Tursiops truncatus ENSTTRG00000017084 N 0.862
SIM1 Vicugna pacos ENSVPAG00000001407 N 0.914
ENSXMAG00000016785 Xiphophorus maculatus ENSXMAG00000016785 N 0.882
ENSXMAG00000019075 Xiphophorus maculatus ENSXMAG00000019075 N 0.914
estExt_GenewiseH_1.C_790104 Branchiostoma floridae estExt_GenewiseH_1.C_790104 N 0.862
Gfo_R003852 Geospiza fortis Gfo_R003852 N 0.914
Gfo_R010900 Geospiza fortis Gfo_R010900 N 0.862
HelroG158226 Helobdella robusta HelroG158226 N 0.851
HelroG89969 Helobdella robusta HelroG89969 N 0.862
HMEL008134 Heliconius melpomene HMEL008134 I 0.838
KGM_03494 Danaus plexippus KGM_03494 I 0.838
L798_01260 Zootermopsis nevadensis L798_01260 N 0.862
LCUP006648 Lucilia cuprina LCUP006648 I 0.838
LotgiG106747 Lottia gigantea LotgiG106747 N 0.862
MDOA008891 Musca domestica MDOA008891 I 0.838
Myotis_brandtii_SIM1_10034719 Myotis brandtii Myotis_brandtii_SIM1_10034719 N 0.914
NV16594 Nasonia vitripennis NV16594 I 0.851
Ocbimv22031168m.g Octopus bimaculoides Ocbimv22031168m.g N 0.862
Ogr12757 Ophisaurus gracilis Ogr12757 N 0.914
PHUM080130 Pediculus humanus PHUM080130 N 0.862
Pvit_04770 Pogona vitticeps Pvit_04770 N 0.862
Pvit_09298 Pogona vitticeps Pvit_09298 N 0.914
PXEA_0002490601 Protopolystoma xenopodis PXEA_0002490601 N 0.894
RPRC001595 Rhodnius prolixus RPRC001595 N 0.894
Sjc_0126700 Schistosoma japonicum Sjc_0126700 N 0.894
SMAR001482 Strigamia maritima SMAR001482 N 0.862
Smp_165270 Schistosoma mansoni Smp_165270 N 0.894
SMRZ_0000943001 Schistosoma margrebowiei SMRZ_0000943001 N 0.894
SMTD_0000610501 Schistosoma mattheei SMTD_0000610501 N 0.894
SMU15015785 Schmidtea mediterranea SMU15015785 N 0.851
SPER_0003947801 Spirometra erinaceieuropaei SPER_0003947801 N 0.851
SPU_013962 Strongylocentrotus purpuratus SPU_013962 N 0.862
SROB_0001806001 Schistosoma rodhaini SROB_0001806001 N 0.894
T265_14441 Opisthorchis viverrini T265_14441 N 0.894
Tal_R009812 Tyto alba Tal_R009812 N 0.894
tetur06g06010 Tetranychus urticae tetur06g06010 N 0.894
TRE_0000325801 Trichobilharzia regenti TRE_0000325801 N 0.894
sim2.S Xenopus laevis XB-GENE-1013959 N 0.862
sim1 Xenopus tropicalis XB-GENE-485816 N 0.914
XP_002941575 Xenopus tropicalis XP_002941575 N 0.862