SIM1 (Homo sapiens)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000112246 T034263_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000262901 bHLH 2 52
ENSP00000358210 bHLH 2 52


Other bHLH family TFs
Other Homo sapiens TFs

195 Related TFs

Name Species Gene ID Motif Evidence SR
MECP2 Anolis carolinensis ENSACAG00000012519 I 0.000
Cmyd_10000498 Chelonia mydas Cmyd_10000498 I 0.000
ENSEEUG00000003070 Erinaceus europaeus ENSEEUG00000003070 I 0.000
MECP2 Homo sapiens ENSG00000169057 D 0.000
ENSLACG00000011281 Latimeria chalumnae ENSLACG00000011281 I 0.000
ENSNLEG00000013783 Nomascus leucogenys ENSNLEG00000013783 I 0.000
ENSONIG00000000809 Oreochromis niloticus ENSONIG00000000809 I 0.000
mecp2 Oryzias latipes ENSORLG00000020117 I 0.000
MECP2 Procavia capensis ENSPCAG00000011826 I 0.000
MECP2 Pteropus vampyrus ENSPVAG00000000472 I 0.000
ENSSSCG00000012796 Sus scrofa ENSSSCG00000012796 I 0.000
mecp2 Takifugu rubripes ENSTRUG00000006419 I 0.000
mecp2 Tetraodon nigroviridis ENSTNIG00000005114 I 0.000