TFEB (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000112561 T034264_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity; enzyme binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to amino acid starvation; lysosome localization; and positive regulation of autophagy. Located in cytosol; lysosomal membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TFEB
M02727_2.00		 Homo sapiens
RTCACGTGAY
RTCACGTGAY		 SELEX
Jolma et al.(2010)
TFEB_dimer		 (Direct) (Direct)
TFEB
M02781_2.00		 Homo sapiens
RNCACGTGAY
RTCACGTGNY		 SELEX
Jolma et al.(2013)
TFEB_1		 (Direct) (Direct)
TFEB
M04088_2.00		 Homo sapiens
YVCACGTGAYN
NRTCACGTGBR		 SELEX
Yin et al.(2017)
TFEB_eDBD_HT-SELEX		 (Direct) (Direct)
TFEB
M04089_2.00		 Homo sapiens
VNCATGTGAYN
NRTCACATGNB		 SELEX
Yin et al.(2017)
TFEB_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
TFEB
M08718_2.00		 Homo sapiens
CACGTGAYY
RRTCACGTG		 Misc
Kulakovskiy et al.(2013)
TFEB_HUMAN.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tfeb
M01728_2.00 		Mus musculus
CWCGTGAY
RTCACGWG		 PBM
Weirauch et al.(2014)
pTH5072 		0.914 1.000
Tfeb
M08753_2.00 		Mus musculus
CACGTGAYY
RRTCACGTG		 Misc
Kulakovskiy et al.(2013)
TFEB_MOUSE.H11MO.0.C 		0.914 1.000
Mitf
M01741_2.00 		Mus musculus
NCDCGTGAYN
NRTCACGHGN		 PBM
Weirauch et al.(2014)
pTH5465 		0.855 0.889
MITF
M08058_2.00 		Homo sapiens
NNNDRTCACGTGAYHNNN
NNNDRTCACGTGAYHNNN		 ChIP-seq
Mathelier et al.(2014)
MA0620.2 		0.855 0.889
MITF
M08740_2.00 		Homo sapiens
YCAYGTGACH
DGTCACRTGR		 Misc
Kulakovskiy et al.(2013)
MITF_HUMAN.H11MO.0.A 		0.855 0.889
Mitf
M08765_2.00 		Mus musculus
BCHYGTGACY
RGTCACRDGV		 Misc
Kulakovskiy et al.(2013)
MITF_MOUSE.H11MO.0.A 		0.855 0.889
Mitf
M09475_2.00 		Mus musculus
GTCACRWGVB
VBCWYGTGAC		 Misc
Heinz et al.(2010)
MastCells-MITF_GSE48085 		0.855 0.889
MITF
M09880_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MITF_Q4 		0.855 0.889
MITF
M09881_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MITF_Q6 		0.855 0.889
Tfe3
M01715_2.00 		Mus musculus
NCDCRTGAYN
NRTCAYGHGN		 PBM
Weirauch et al.(2014)
pTH5057 		0.855 0.870
Tfe3
M05833_2.00 		Mus musculus
CACGTGAY
RTCACGTG		 SMiLE-seq
Isakova et al.(2017)
TFE3 		0.855 0.870
Tfe3
M08743_2.00 		Mus musculus
TCACGTGACH
DGTCACGTGA		 Misc
Kulakovskiy et al.(2013)
TFE3_MOUSE.H11MO.0.A 		0.855 0.870
Tfe3
M09884_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TFEA_01 		0.855 0.870
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000230323 bHLH 236 289
ENSP00000343948 bHLH 322 375
ENSP00000351742 bHLH 250 303
ENSP00000362124 bHLH 236 289
ENSP00000377824 bHLH 236 267
ENSP00000383998 bHLH 94 147
ENSP00000384203 bHLH 236 289
ENSP00000410391 bHLH 236 267
ENSP00000412551 bHLH 151 204

Links

Other bHLH family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

153 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action