HAND1 (Homo sapiens)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000113196 T034265_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Mus musculus

Kulakovskiy et al.(2013)
0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000231121 bHLH 95 147


Other bHLH family TFs
Other Homo sapiens TFs

54 Related TFs

Name Species Gene ID Motif Evidence SR
ENSPANG00000013720 Papio anubis ENSPANG00000013720 I 0.914
HAND1 Procavia capensis ENSPCAG00000006706 I 0.914
ENSPPYG00000015975 Pongo abelii ENSPPYG00000015975 I 0.914
HAND1 Pan troglodytes ENSPTRG00000017446 I 0.914
HAND1 Ochotona princeps ENSOPRG00000014560 I 0.914
HAND1 Otolemur garnettii ENSOGAG00000024691 I 0.914
ENSNLEG00000016584 Nomascus leucogenys ENSNLEG00000016584 I 0.914
ENSAMEG00000016692 Ailuropoda melanoleuca ENSAMEG00000016692 I 0.914
ENSOARG00000009843 Ovis aries ENSOARG00000009843 I 0.914
HAND1 Oryctolagus cuniculus ENSOCUG00000011099 I 0.914
HAND1 Pteropus vampyrus ENSPVAG00000002261 I 0.914
Hand1 Rattus norvegicus ENSRNOG00000002582 I 0.914
Alligator_sinensis_CCG014990.1 Alligator sinensis Alligator_sinensis_CCG014990.1 I 0.914
ENSBTAP00000003015-D1 Bos grunniens ENSBTAP00000003015-D1 I 0.914
ENSP00000231121 Macaca fascicularis ENSP00000231121 I 0.914
Myotis_brandtii_HAND1_10034795 Myotis brandtii Myotis_brandtii_HAND1_10034795 I 0.914
Afo_R012042 Aptenodytes forsteri Afo_R012042 I 0.914
Aan_R010602 Calypte anna Aan_R010602 I 0.914
ENSSHAG00000009358 Sarcophilus harrisii ENSSHAG00000009358 I 0.914
ENSSSCG00000017070 Sus scrofa ENSSSCG00000017070 I 0.914
ENSSTOG00000025850 Ictidomys tridecemlineatus ENSSTOG00000025850 I 0.914
HAND1 Tursiops truncatus ENSTTRG00000002725 I 0.914
Hand1 Mus musculus ENSMUSG00000037335 D 0.914
HAND1 Ornithorhynchus anatinus ENSOANG00000005097 I 0.914
Hand1 Dipodomys ordii ENSDORG00000015170 I 0.914
HAND1 Dasypus novemcinctus ENSDNOG00000007934 I 0.914
HAND1 Equus caballus ENSECAG00000005327 I 0.914
HAND1 Erinaceus europaeus ENSEEUG00000003255 I 0.914
ENSMPUG00000013570 Mustela putorius furo ENSMPUG00000013570 I 0.914
ENSCSAG00000010805 Chlorocebus sabaeus ENSCSAG00000010805 I 0.914
HAND1 Cavia porcellus ENSCPOG00000024064 I 0.914
ENSAPLG00000007863 Anas platyrhynchos ENSAPLG00000007863 I 0.914
HAND1 Bos taurus ENSBTAG00000002335 I 0.914
HAND1 Canis familiaris ENSCAFG00000017641 I 0.914
HAND1 Callithrix jacchus ENSCJAG00000009817 I 0.914
HAND1 Felis catus ENSFCAG00000014986 I 0.914
ENSFALG00000008331 Ficedula albicollis ENSFALG00000008331 I 0.914
HAND1 Loxodonta africana ENSLAFG00000017517 I 0.914
HAND1 Myotis lucifugus ENSMLUG00000008901 I 0.914
HAND1 Macaca mulatta ENSMMUG00000010621 I 0.914
HAND1 Monodelphis domestica ENSMODG00000008678 I 0.914
ENSLACG00000018666 Latimeria chalumnae ENSLACG00000018666 I 0.914
HAND1 Gorilla gorilla ENSGGOG00000004311 I 0.914
ENSGALG00000026787 Gallus gallus ENSGALG00000026787 I 0.914
HAND1 Oryzias latipes ENSORLG00000015508 I 0.894
HAND1 Gasterosteus aculeatus ENSGACG00000020816 I 0.894
ENSPFOG00000012614 Poecilia formosa ENSPFOG00000012614 I 0.894
HAND1 Tetraodon nigroviridis ENSTNIG00000007631 I 0.894
ENSONIG00000013234 Oreochromis niloticus ENSONIG00000013234 I 0.894
HAND1 Takifugu rubripes ENSTRUG00000003992 I 0.894
ENSXMAG00000015432 Xiphophorus maculatus ENSXMAG00000015432 I 0.894
HAND1 Echinops telfairi ENSETEG00000010988 I 0.861
SPU_017287 Strongylocentrotus purpuratus SPU_017287 I 0.846
HAND2 Homo sapiens ENSG00000164107 D 0.393