MXI1 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000119950 T034270_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MXI1
M07790_2.00
Homo sapiens
VVVNCCACGTG

CACGTGGNBBB
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_MXI1_Stanford
(Direct) (Direct)
MXI1
M08051_2.00
Homo sapiens
NNNCCACGTGSNN

NNSCACGTGGNNN
ChIP-seq
Mathelier et al.(2014)
MA1108.1
(Direct) (Direct)
MXI1
M08181_2.00
Homo sapiens
BGTTGCCAKGGMRAC

GTYKCCMTGGCAACV
ChIP-seq
Contrino et al.(2012)
Mv93
(Direct) (Direct)
MXI1
M08182_2.00
Homo sapiens
CCACGTGG

CCACGTGG
ChIP-seq
Contrino et al.(2012)
Mv94
(Direct) (Direct)
MXI1
M08720_2.00
Homo sapiens
VCACGTGBSNBBNNV

BNNVVNSVCACGTGB
Misc
Kulakovskiy et al.(2013)
MXI1_HUMAN.H11MO.0.A
(Direct) (Direct)
MXI1
M09828_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MXI1_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Mxi1
M08754_2.00
Mus musculus
VCACGTGBSNBBNNV

BNNVVNSVCACGTGB
Misc
Kulakovskiy et al.(2013)
MXI1_MOUSE.H11MO.0.A
0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000239007 bHLH 68 120
ENSP00000239007 bHLH 148 167
ENSP00000331152 bHLH 135 187
ENSP00000354606 bHLH 27 74
ENSP00000354606 bHLH 102 121
ENSP00000358625 bHLH 32 84
ENSP00000376842 bHLH 63 110
ENSP00000376842 bHLH 138 157
ENSP00000398981 bHLH 130 177
ENSP00000407711 bHLH 32 84

Links

Other bHLH family TFs
Other Homo sapiens TFs

142 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSPFOG00000021922 Poecilia formosa ENSPFOG00000021922 I 0.914
ENSPFOG00000017086 Poecilia formosa ENSPFOG00000017086 I 0.914
ENSPANG00000020804 Papio anubis ENSPANG00000020804 I 0.914
ENSONIG00000016308 Oreochromis niloticus ENSONIG00000016308 I 0.914
ENSPPYG00000002642 Pongo abelii ENSPPYG00000002642 I 0.914
ENSPSIG00000012742 Pelodiscus sinensis ENSPSIG00000012742 I 0.914
Mxi1 Rattus norvegicus ENSRNOG00000034078 I 0.914
MXI1 Pteropus vampyrus ENSPVAG00000014983 I 0.914
MXI1 Pan troglodytes ENSPTRG00000002936 I 0.914
ENSONIG00000000432 Oreochromis niloticus ENSONIG00000000432 I 0.914
MXI1 Otolemur garnettii ENSOGAG00000000570 I 0.914
MXI1 Monodelphis domestica ENSMODG00000010546 I 0.914
MXI1 Macaca mulatta ENSMMUG00000014350 I 0.914
ENSMLUG00000016004 Myotis lucifugus ENSMLUG00000016004 I 0.914
MXI1 Meleagris gallopavo ENSMGAG00000010768 I 0.914
ENSMPUG00000002095 Mustela putorius furo ENSMPUG00000002095 I 0.914
Mxi1 Mus musculus ENSMUSG00000025025 D 0.914
ENSOARG00000009456 Ovis aries ENSOARG00000009456 I 0.914
MXI1 Ornithorhynchus anatinus ENSOANG00000001600 I 0.914
ENSNLEG00000015457 Nomascus leucogenys ENSNLEG00000015457 I 0.914
ENSSHAG00000015280 Sarcophilus harrisii ENSSHAG00000015280 N 0.914
MXI1 Sus scrofa ENSSSCG00000022128 N 0.914
Gfo_R002259 Geospiza fortis Gfo_R002259 I 0.914
ENSP00000331152 Macaca fascicularis ENSP00000331152 I 0.914
ENSBTAP00000048182-D1 Bos grunniens ENSBTAP00000048182-D1 I 0.914
Cmyd_10011617 Chelonia mydas Cmyd_10011617 N 0.914
Myotis_brandtii_Mxi1_10027965 Myotis brandtii Myotis_brandtii_Mxi1_10027965 I 0.914
Ogr11151 Ophisaurus gracilis Ogr11151 I 0.914
mxi1 Xenopus tropicalis XB-GENE-493086 I 0.914
Tal_R006513 Tyto alba Tal_R006513 I 0.914
Pvit_07222 Pogona vitticeps Pvit_07222 I 0.914
Afo_R002778 Aptenodytes forsteri Afo_R002778 I 0.914
ENSXMAG00000012758 Xiphophorus maculatus ENSXMAG00000012758 I 0.914
ENSTGUG00000010598 Taeniopygia guttata ENSTGUG00000010598 I 0.914
ENSTBEG00000017602 Tupaia belangeri ENSTBEG00000017602 I 0.914
ENSSTOG00000025776 Ictidomys tridecemlineatus ENSSTOG00000025776 I 0.914
MXI1 Tetraodon nigroviridis ENSTNIG00000013330 I 0.914
MXI1 Takifugu rubripes ENSTRUG00000006785 I 0.914
ENSXMAG00000007056 Xiphophorus maculatus ENSXMAG00000007056 I 0.914
MXI1 Vicugna pacos ENSVPAG00000003400 I 0.914
MXI1 Tursiops truncatus ENSTTRG00000007895 I 0.914
ENSLOCG00000012358 Lepisosteus oculatus ENSLOCG00000012358 I 0.914
mxi1 Oryzias latipes ENSORLG00000015172 I 0.914
MXI1 Bos taurus ENSBTAG00000017263 I 0.914
MXI1 Dasypus novemcinctus ENSDNOG00000002479 I 0.914
ENSAPLG00000004350 Anas platyrhynchos ENSAPLG00000004350 I 0.914
ENSAMXG00000004433 Astyanax mexicanus ENSAMXG00000004433 I 0.914
MXI1 Callithrix jacchus ENSCJAG00000018614 I 0.914
MXI1 Felis catus ENSFCAG00000004882 I 0.914
Mxi1 Dipodomys ordii ENSDORG00000005656 I 0.914
MXI1 Canis familiaris ENSCAFG00000010706 I 0.914
ENSFALG00000002308 Ficedula albicollis ENSFALG00000002308 I 0.914
MXI1 Choloepus hoffmanni ENSCHOG00000006556 I 0.914
MXI1 Gallus gallus ENSGALG00000008555 I 0.914
MXI1 Loxodonta africana ENSLAFG00000014348 I 0.914
MXI1 Anolis carolinensis ENSACAG00000006009 I 0.914
MXI1 Cavia porcellus ENSCPOG00000022901 I 0.914
MXI1 Gorilla gorilla ENSGGOG00000013614 I 0.914
ENSCSAG00000005171 Chlorocebus sabaeus ENSCSAG00000005171 I 0.914
ENSAMEG00000005262 Ailuropoda melanoleuca ENSAMEG00000005262 I 0.914
MXI1 Oryzias latipes ENSORLG00000005955 I 0.903
Aan_R004657 Calypte anna Aan_R004657 I 0.894
RPRC006485 Rhodnius prolixus RPRC006485 I 0.892
HHAL004586-PA Halyomorpha halys HHAL004586-PA N 0.892
mxi1 Danio rerio ENSDARG00000040884 I 0.886
ENSLOCG00000015320 Lepisosteus oculatus ENSLOCG00000015320 I 0.885
ENSXMAG00000004566 Xiphophorus maculatus ENSXMAG00000004566 I 0.885
ENSPFOG00000004367 Poecilia formosa ENSPFOG00000004367 I 0.885
mxd1 Oryzias latipes ENSORLG00000015461 I 0.885
ENSONIG00000015871 Oreochromis niloticus ENSONIG00000015871 I 0.885
mxd1 Tetraodon nigroviridis ENSTNIG00000000414 I 0.885
ENSCPOG00000000336 Cavia porcellus ENSCPOG00000000336 I 0.885
mxd1 Takifugu rubripes ENSTRUG00000014843 N 0.885
mxi1 Tetraodon nigroviridis ENSTNIG00000010585 I 0.879
mxi1.L Xenopus laevis XB-GENE-865794 I 0.879
fgenesh2_pg.scaffold_205000025 Branchiostoma floridae fgenesh2_pg.scaffold_205000025 I 0.866
fgenesh2_pg.scaffold_205000024 Branchiostoma floridae fgenesh2_pg.scaffold_205000024 N 0.866
NV10716 Nasonia vitripennis NV10716 I 0.864
ACYPI005198 Acyrthosiphon pisum ACYPI005198 I 0.864
SINV22225 Solenopsis invicta SINV22225 N 0.864
ENSPMAG00000001074 Petromyzon marinus ENSPMAG00000001074 I 0.864
Brh_R004607 Buceros rhinoceros Brh_R004607 I 0.861
ENSTGUG00000015302 Taeniopygia guttata ENSTGUG00000015302 I 0.861
ENSTSYG00000006623 Tarsius syrichta ENSTSYG00000006623 I 0.861
ENSLACG00000017438 Latimeria chalumnae ENSLACG00000017438 I 0.860
ENSAMEG00000016108 Ailuropoda melanoleuca ENSAMEG00000016108 I 0.858
MXD1 Callithrix jacchus ENSCJAG00000019266 I 0.858
Ogr05439 Ophisaurus gracilis Ogr05439 I 0.858
Pvit_06637 Pogona vitticeps Pvit_06637 I 0.858
MXD1 Anolis carolinensis ENSACAG00000006004 I 0.858
ENSP00000264444 Macaca fascicularis ENSP00000264444 I 0.858
ENSP00000264444-D1 Bos grunniens ENSP00000264444-D1 I 0.858
MXD1 Choloepus hoffmanni ENSCHOG00000003047 I 0.858
MXD1 Vicugna pacos ENSVPAG00000001762 I 0.858
Cmyd_10006239 Chelonia mydas Cmyd_10006239 I 0.858
MXD1 Canis familiaris ENSCAFG00000032746 I 0.858
MXD1 Bos taurus ENSBTAG00000001042 I 0.858
Alligator_sinensis_CCG019430.1 Alligator sinensis Alligator_sinensis_CCG019430.1 I 0.858
MXD1 Sus scrofa ENSSSCG00000008334 I 0.858
MXD1 Oryctolagus cuniculus ENSOCUG00000015820 I 0.858
ENSOARG00000019742 Ovis aries ENSOARG00000019742 I 0.858
ENSOANG00000003095 Ornithorhynchus anatinus ENSOANG00000003095 N 0.858
MXD1 Homo sapiens ENSG00000059728 I 0.858
MXD1 Otolemur garnettii ENSOGAG00000008412 I 0.858
ENSCPOG00000007162 Cavia porcellus ENSCPOG00000007162 I 0.858
ENSPANG00000000314 Papio anubis ENSPANG00000000314 I 0.858
MXD1 Felis catus ENSFCAG00000030345 I 0.858
ENSGACG00000018716 Gasterosteus aculeatus ENSGACG00000018716 I 0.858
ENSNLEG00000010141 Nomascus leucogenys ENSNLEG00000010141 I 0.858
ENSMMUG00000010226 Macaca mulatta ENSMMUG00000010226 I 0.858
ENSGMOG00000014798 Gadus morhua ENSGMOG00000014798 I 0.858
ENSMEUG00000013693 Macropus eugenii ENSMEUG00000013693 I 0.858
MXD1 Gorilla gorilla ENSGGOG00000011287 I 0.858
MXD1 Monodelphis domestica ENSMODG00000011481 I 0.858
Mxd1 Mus musculus ENSMUSG00000001156 I 0.858
ENSMPUG00000007107 Mustela putorius furo ENSMPUG00000007107 I 0.858
MXI1 Procavia capensis ENSPCAG00000016142 I 0.858
MXD1 Procavia capensis ENSPCAG00000001189 I 0.858
MXD1 Sorex araneus ENSSARG00000004728 I 0.858
Mxd1 Rattus norvegicus ENSRNOG00000017720 I 0.858
MXD1 Dasypus novemcinctus ENSDNOG00000034010 I 0.858
ENSSHAG00000005374 Sarcophilus harrisii ENSSHAG00000005374 I 0.858
ENSCSAG00000015119 Chlorocebus sabaeus ENSCSAG00000015119 I 0.858
MXD1 Tupaia belangeri ENSTBEG00000005535 I 0.858
ENSSTOG00000000718 Ictidomys tridecemlineatus ENSSTOG00000000718 I 0.858
MXD1 Pan troglodytes ENSPTRG00000012023 I 0.858
MXD1 Pteropus vampyrus ENSPVAG00000001244 I 0.858
MXD1 Echinops telfairi ENSETEG00000017347 I 0.858
MXI1 Echinops telfairi ENSETEG00000018880 I 0.858
ENSPPYG00000012331 Pongo abelii ENSPPYG00000012331 I 0.858
MXD1 Equus caballus ENSECAG00000011257 I 0.858
ENSDORG00000001608 Dipodomys ordii ENSDORG00000001608 I 0.858
LotgiG220594 Lottia gigantea LotgiG220594 I 0.856
EFV61981 Trichinella spiralis EFV61981 I 0.856
Sakowv30007563m.g Saccoglossus kowalevskii Sakowv30007563m.g I 0.852
PHUM333690 Pediculus humanus PHUM333690 N 0.852
MXD1 Meleagris gallopavo ENSMGAG00000003405 I 0.845
MXD1 Gallus gallus ENSGALG00000013882 I 0.845
SPU_006583 Strongylocentrotus purpuratus SPU_006583 I 0.845
tetur09g05570 Tetranychus urticae tetur09g05570 I 0.842
mxd1 Gasterosteus aculeatus ENSGACG00000013215 I 0.839