MXI1 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000119950 T034270_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MXI1
M07790_2.00		 Homo sapiens
VVVNCCACGTG
CACGTGGNBBB		 ChIP-seq
Gerstein et al.(2012)
HeLa-S3_MXI1_Stanford		 (Direct) (Direct)
MXI1
M08051_2.00		 Homo sapiens
NNNCCACGTGSNN
NNSCACGTGGNNN		 ChIP-seq
Mathelier et al.(2014)
MA1108.1		 (Direct) (Direct)
MXI1
M08181_2.00		 Homo sapiens
BGTTGCCAKGGMRAC
GTYKCCMTGGCAACV		 ChIP-seq
Contrino et al.(2012)
Mv93		 (Direct) (Direct)
MXI1
M08182_2.00		 Homo sapiens
CCACGTGG
CCACGTGG		 ChIP-seq
Contrino et al.(2012)
Mv94		 (Direct) (Direct)
MXI1
M08720_2.00		 Homo sapiens
VCACGTGBSNBBNNV
BNNVVNSVCACGTGB		 Misc
Kulakovskiy et al.(2013)
MXI1_HUMAN.H11MO.0.A		 (Direct) (Direct)
MXI1
M09828_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MXI1_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Mxi1
M08754_2.00 		Mus musculus
VCACGTGBSNBBNNV
BNNVVNSVCACGTGB		 Misc
Kulakovskiy et al.(2013)
MXI1_MOUSE.H11MO.0.A 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000239007 bHLH 68 120
ENSP00000239007 bHLH 148 167
ENSP00000331152 bHLH 135 187
ENSP00000354606 bHLH 27 74
ENSP00000354606 bHLH 102 121
ENSP00000358625 bHLH 32 84
ENSP00000376842 bHLH 63 110
ENSP00000376842 bHLH 138 157
ENSP00000398981 bHLH 130 177
ENSP00000407711 bHLH 32 84

Links

Other bHLH family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

142 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action