BHLHE23 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000125533 T034280_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BHLHE23
M02784_2.00
Homo sapiens
RVCATATGBY

RVCATATGBY
SELEX
Jolma et al.(2013)
BHLHE23_1
(Direct) (Direct)
BHLHE23
M04108_2.00
Homo sapiens
AVCATATGBY

RVCATATGBT
SELEX
Yin et al.(2017)
BHLHE23_eDBD_HT-SELEX
(Direct) (Direct)
BHLHE23
M04109_2.00
Homo sapiens
AVCATATGBY

RVCATATGBT
SELEX
Yin et al.(2017)
BHLHE23_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
BHLHE23
M04110_2.00
Homo sapiens
RVCATATGBY

RVCATATGBY
SELEX
Yin et al.(2017)
BHLHE23_FL_HT-SELEX
(Direct) (Direct)
BHLHE23
M04111_2.00
Homo sapiens
RVCATATGBY

RVCATATGBY
SELEX
Yin et al.(2017)
BHLHE23_FL_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Bhlhe22
M01729_2.00
Mus musculus
NVCATATGGN

NCCATATGBN
PBM
Weirauch et al.(2014)
pTH5267
0.914 0.963
BHLHE22
M02804_2.00
Homo sapiens
NAVCATATGBTN

NAVCATATGBTN
SELEX
Jolma et al.(2013)
BHLHE22_1
0.914 0.963
BHLHE22
M04199_2.00
Homo sapiens
AVCATATGBY

RVCATATGBT
SELEX
Yin et al.(2017)
BHLHE22_eDBD_HT-SELEX
0.914 0.963
BHLHE22
M04200_2.00
Homo sapiens
AVCATATGBY

RVCATATGBT
SELEX
Yin et al.(2017)
BHLHE22_eDBD_Methyl-HT-SELEX
0.914 0.963
Oli
M03618_2.00
Drosophila melanogaster
AMCATATGKY

RMCATATGKT
SELEX
Nitta et al.(2015)
Oli_1
0.890 0.926
Oli
M05985_2.00
Drosophila melanogaster
SACCATATGKY

RMCATATGGTS
B1H
Zhu et al.(2011)
Oli_da_SANGER_5_1_FBgn0032651
0.890 0.926
Oli
M05986_2.00
Drosophila melanogaster
AHSBNRCCATMTGKY

RMCAKATGGYNVSDT
B1H
Zhu et al.(2011)
Oli_da_SANGER_5_2_FBgn0032651
0.890 0.926
Oli
M05987_2.00
Drosophila melanogaster
MCATCTGKY

RMCAGATGK
B1H
Zhu et al.(2011)
Oli_da_SANGER_5_3_FBgn0032651
0.890 0.926
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000359371 bHLH 101 154
ENSP00000480998 bHLH 117 170

Links

Other bHLH family TFs
Other Homo sapiens TFs

147 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ACOC_0000564301 Angiostrongylus costaricensis ACOC_0000564301 N 0.000
ALUE_0000326401 Ascaris lumbricoides ALUE_0000326401 I 0.000
ANCCAN_03591 Ancylostoma caninum ANCCAN_03591 N 0.000
ANCCEY_10263 Ancylostoma ceylanicum ANCCEY_10263 N 0.000
ASIM_0001335601 Anisakis simplex ASIM_0001335601 I 0.000
ASU_05094 Ascaris suum ASU_05094 I 0.000
BGLB003270 Biomphalaria glabrata BGLB003270 I 0.000
Bm7588 Brugia malayi Bm7588 I 0.000
BTMF_0000617301 Brugia timori BTMF_0000617301 I 0.000
CBG19808 Caenorhabditis briggsae CBG19808 I 0.000
CBN32559 Caenorhabditis brenneri CBN32559 I 0.000
ces-2 Caenorhabditis elegans WBGene00000469 D 0.000
CGI_10015382 Crassostrea gigas CGI_10015382 N 0.000
CGI_10024700 Crassostrea gigas CGI_10024700 N 0.000
CJA10655 Caenorhabditis japonica CJA10655 I 0.000
CLEC000050 Cimex lectularius CLEC000050 N 0.000
CLEC001633 Cimex lectularius CLEC001633 N 0.000
CRE13954 Caenorhabditis remanei CRE13954 I 0.000
DICVIV_06567 Dictyocaulus viviparus DICVIV_06567 I 0.000
DME_0000215901 Dracunculus medinensis DME_0000215901 I 0.000
EEL_0000071901 Elaeophora elaphi EEL_0000071901 I 0.000
EFV48635 Trichinella spiralis EFV48635 N 0.000
GPUH_0000579801 Gongylonema pulchrum GPUH_0000579801 I 0.000
HelroG146802 Helobdella robusta HelroG146802 N 0.000
HPLM_0000323401 Haemonchus placei HPLM_0000323401 I 0.000
L596_g21771 Steinernema carpocapsae L596_g21771 N 0.000
L596_g3194 Steinernema carpocapsae L596_g3194 I 0.000
L892_g28108 Steinernema scapterisci L892_g28108 N 0.000
L893_g26459 Steinernema glaseri L893_g26459 I 0.000
L898_g30246 Steinernema monticolum L898_g30246 I 0.000
LDEC005996 Leptinotarsa decemlineata LDEC005996 N 0.000
LOAG_04491 Loa loa LOAG_04491 I 0.000
LotgiG89985 Lottia gigantea LotgiG89985 N 0.000
nAv.1.0.1.g06570 Acanthocheilonema viteae nAv.1.0.1.g06570 I 0.000
nDi.2.2.2.g01315 Dirofilaria immitis nDi.2.2.2.g01315 I 0.000
nDi.2.2.2.g10294 Dirofilaria immitis nDi.2.2.2.g10294 I 0.000
NECAME_03378 Necator americanus NECAME_03378 N 0.000
nLs.2.1.2.g06633 Litomosoides sigmodontis nLs.2.1.2.g06633 I 0.000
nOo.2.0.1.g09202 Onchocerca ochengi nOo.2.0.1.g09202 I 0.000
OFLC_0001455401 Onchocerca flexuosa OFLC_0001455401 I 0.000
PEQ_0001019701 Parascaris equorum PEQ_0001019701 I 0.000
PTRK_0001316500 Parastrongyloides trichosuri PTRK_0001316500 I 0.000
RPRC001027 Rhodnius prolixus RPRC001027 N 0.000
Sakowv30032301m.g Saccoglossus kowalevskii Sakowv30032301m.g N 0.000
SMUV_0001027601 Syphacia muris SMUV_0001027601 I 0.000
SPU_014528 Strongylocentrotus purpuratus SPU_014528 N 0.000
SPU_021150 Strongylocentrotus purpuratus SPU_021150 I 0.000
SSTP_0000025200 Strongyloides stercoralis SSTP_0000025200 I 0.000
SVE_0152400 Strongyloides venezuelensis SVE_0152400 I 0.000
WBGene00237430 Onchocerca volvulus WBGene00237430 I 0.000
WUBG_01294 Wuchereria bancrofti WUBG_01294 I 0.000