BHLHE23 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000125533 T034280_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BHLHE23
M02784_2.00
Homo sapiens
RVCATATGBY

RVCATATGBY
SELEX
Jolma et al.(2013)
BHLHE23_1
(Direct) (Direct)
BHLHE23
M04108_2.00
Homo sapiens
AVCATATGBY

RVCATATGBT
SELEX
Yin et al.(2017)
BHLHE23_eDBD_HT-SELEX
(Direct) (Direct)
BHLHE23
M04109_2.00
Homo sapiens
AVCATATGBY

RVCATATGBT
SELEX
Yin et al.(2017)
BHLHE23_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
BHLHE23
M04110_2.00
Homo sapiens
RVCATATGBY

RVCATATGBY
SELEX
Yin et al.(2017)
BHLHE23_FL_HT-SELEX
(Direct) (Direct)
BHLHE23
M04111_2.00
Homo sapiens
RVCATATGBY

RVCATATGBY
SELEX
Yin et al.(2017)
BHLHE23_FL_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Bhlhe22
M01729_2.00
Mus musculus
NVCATATGGN

NCCATATGBN
PBM
Weirauch et al.(2014)
pTH5267
0.914 0.963
BHLHE22
M02804_2.00
Homo sapiens
NAVCATATGBTN

NAVCATATGBTN
SELEX
Jolma et al.(2013)
BHLHE22_1
0.914 0.963
BHLHE22
M04199_2.00
Homo sapiens
AVCATATGBY

RVCATATGBT
SELEX
Yin et al.(2017)
BHLHE22_eDBD_HT-SELEX
0.914 0.963
BHLHE22
M04200_2.00
Homo sapiens
AVCATATGBY

RVCATATGBT
SELEX
Yin et al.(2017)
BHLHE22_eDBD_Methyl-HT-SELEX
0.914 0.963
Oli
M03618_2.00
Drosophila melanogaster
AMCATATGKY

RMCATATGKT
SELEX
Nitta et al.(2015)
Oli_1
0.890 0.926
Oli
M05985_2.00
Drosophila melanogaster
SACCATATGKY

RMCATATGGTS
B1H
Zhu et al.(2011)
Oli_da_SANGER_5_1_FBgn0032651
0.890 0.926
Oli
M05986_2.00
Drosophila melanogaster
AHSBNRCCATMTGKY

RMCAKATGGYNVSDT
B1H
Zhu et al.(2011)
Oli_da_SANGER_5_2_FBgn0032651
0.890 0.926
Oli
M05987_2.00
Drosophila melanogaster
MCATCTGKY

RMCAGATGK
B1H
Zhu et al.(2011)
Oli_da_SANGER_5_3_FBgn0032651
0.890 0.926
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000359371 bHLH 101 154
ENSP00000480998 bHLH 117 170

Links

Other bHLH family TFs
Other Homo sapiens TFs

147 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ACYPI000347 Acyrthosiphon pisum ACYPI000347 I 0.890
AAEL000341 Aedes aegypti AAEL000341 I 0.890
BHLHE22 Anolis carolinensis ENSACAG00000016834 I 0.890
AALB000147 Anopheles albimanus AALB000147 I 0.890
AARA008760 Anopheles arabiensis AARA008760 I 0.890
AATE004759 Anopheles atroparvus AATE004759 I 0.890
ACHR009203 Anopheles christyi ACHR009203 I 0.890
ACOM027056 Anopheles coluzzii ACOM027056 I 0.890
ACUA002460 Anopheles culicifacies ACUA002460 I 0.890
ADAC006720 Anopheles darlingi ADAC006720 I 0.890
ADIR006306 Anopheles dirus ADIR006306 I 0.890
AEPI003977 Anopheles epiroticus AEPI003977 I 0.890
AFAF017781 Anopheles farauti AFAF017781 I 0.890
AFUN005189 Anopheles funestus AFUN005189 I 0.890
AGAP009227 Anopheles gambiae AGAP009227 I 0.890
AMAM023008 Anopheles maculatus AMAM023008 I 0.914
AMEC008134 Anopheles melas AMEC008134 I 0.890
AMEM014256 Anopheles merus AMEM014256 I 0.890
AMIN009758 Anopheles minimus AMIN009758 I 0.890
AQUA010475 Anopheles quadriannulatus AQUA010475 I 0.890
ASIS008310 Anopheles sinensis ASIS008310 I 0.890
ASTEI052404 Anopheles stephensi ASTEI052404 I 0.890
GB45050 Apis mellifera GB45050 I 0.914
Afo_R010903 Aptenodytes forsteri Afo_R010903 I 0.890
ENSAMXG00000026338 Astyanax mexicanus ENSAMXG00000026338 I 0.914
ENSAMXG00000025627 Astyanax mexicanus ENSAMXG00000025627 I 0.890
ACEP10921 Atta cephalotes ACEP10921 I 0.914
BGLB010842 Biomphalaria glabrata BGLB010842 I 0.890
BGIBMGA003134 Bombyx mori BGIBMGA003134 I 0.890
ENSBTAP00000014445-D1 Bos grunniens ENSBTAP00000014445-D1 I 0.890
BHLHE22 Bos taurus ENSBTAG00000033173 I 0.914
BHLHE23 Bos taurus ENSBTAG00000010873 I 0.914
fgenesh2_pg.scaffold_122000082 Branchiostoma floridae fgenesh2_pg.scaffold_122000082 I 0.890
BHLHE22 Callithrix jacchus ENSCJAG00000009234 I 0.914
BHLHE23 Callithrix jacchus ENSCJAG00000010053 I 0.914
Cflo_04767--XP_001122321.1_APIME Camponotus floridanus Cflo_04767--XP_001122321.1_APIME I 0.914
CapteG184404 Capitella teleta CapteG184404 I 0.890
BHLHE22 Cavia porcellus ENSCPOG00000004652 I 0.890
ENSCSAG00000018736 Chlorocebus sabaeus ENSCSAG00000018736 I 0.914
ENSCSAG00000018550 Chlorocebus sabaeus ENSCSAG00000018550 I 0.914
CGI_10006402 Crassostrea gigas CGI_10006402 I 0.882
CpipJ_CPIJ000843 Culex pipiens CpipJ_CPIJ000843 I 0.890
CPIJ000843 Culex quinquefasciatus CPIJ000843 I 0.890
bhlhe23 Danio rerio ENSDARG00000037588 I 0.890
bhlhe22 Danio rerio ENSDARG00000058039 I 0.890
DAPPUDRAFT_17020 Daphnia pulex DAPPUDRAFT_17020 I 0.890
BHLHE23 Dasypus novemcinctus ENSDNOG00000036826 I 0.890
BHLHE22 Dasypus novemcinctus ENSDNOG00000004738 I 0.914
YQE_08596 Dendroctonus ponderosae YQE_08596 I 0.890
DILT_0000047901 Diphyllobothrium latum DILT_0000047901 I 0.844
ENSDORG00000012788 Dipodomys ordii ENSDORG00000012788 I 0.890
GF14803 Drosophila ananassae FBgn0091830 I 0.890
GG21094 Drosophila erecta FBgn0113277 I 0.890
GH11626 Drosophila grimshawi FBgn0119106 I 0.890
Oli Drosophila melanogaster FBgn0032651 D 0.890
GI17928 Drosophila mojavensis FBgn0140669 I 0.890
GL14513 Drosophila persimilis FBgn0152118 I 0.890
GA18959 Drosophila pseudoobscura FBgn0078958 I 0.890
GM17248 Drosophila sechellia FBgn0172159 I 0.890
GD24118 Drosophila simulans FBgn0195474 I 0.890
GJ17701 Drosophila virilis FBgn0204870 I 0.890
GK18164 Drosophila willistoni FBgn0220163 I 0.890
GE12799 Drosophila yakuba FBgn0230520 I 0.890
ECPE_0000755301 Echinostoma caproni ECPE_0000755301 I 0.890
D915_05889 Fasciola hepatica D915_05889 I 0.890
ENSFALG00000010468 Ficedula albicollis ENSFALG00000010468 I 0.890
ENSGMOG00000014009 Gadus morhua ENSGMOG00000014009 I 0.890
ENSGMOG00000019833 Gadus morhua ENSGMOG00000019833 I 0.914
BHLHE23 Gallus gallus ENSGALG00000005718 I 0.890
bhlhe22 Gasterosteus aculeatus ENSGACG00000002995 I 0.890
BHLHE23 Gorilla gorilla ENSGGOG00000025870 I 0.914
Hsal_10753--XP_001122321.1_APIME Harpegnathos saltator Hsal_10753--XP_001122321.1_APIME I 0.914
HelroG128595 Helobdella robusta HelroG128595 I 0.882
BHLHE22 Homo sapiens ENSG00000180828 D 0.914
ISCW009607 Ixodes scapularis ISCW009607 I 0.914
ENSLACG00000007038 Latimeria chalumnae ENSLACG00000007038 I 0.890
ENSLACG00000016169 Latimeria chalumnae ENSLACG00000016169 I 0.890
ENSLOCG00000018362 Lepisosteus oculatus ENSLOCG00000018362 I 0.890
ENSLOCG00000017814 Lepisosteus oculatus ENSLOCG00000017814 I 0.890
LDEC023792 Leptinotarsa decemlineata LDEC023792 I 0.914
LCUP009688 Lucilia cuprina LCUP009688 I 0.890
LLOJ009613 Lutzomyia longipalpis LLOJ009613 I 0.890
ENSMMUG00000028979 Macaca mulatta ENSMMUG00000028979 I 0.914
MESCA002512 Megaselia scalaris MESCA002512 I 0.890
BHLHE23 Meleagris gallopavo ENSMGAG00000006134 I 0.890
MCINX007709 Melitaea cinxia MCINX007709 I 0.890
BHLHE23 Monodelphis domestica ENSMODG00000023267 I 0.890
BHLHE22 Monodelphis domestica ENSMODG00000008228 I 0.914
MDOA001134 Musca domestica MDOA001134 I 0.890
Bhlhe23 Mus musculus ENSMUSG00000045493 I 0.890
Bhlhe22 Mus musculus ENSMUSG00000025128 D 0.914
BHLHE22 Myotis lucifugus ENSMLUG00000002156 I 0.890
NV11426 Nasonia vitripennis NV11426 I 0.914
ENSNLEG00000019167 Nomascus leucogenys ENSNLEG00000019167 I 0.914
Ogr12490 Ophisaurus gracilis Ogr12490 I 0.890
ENSONIG00000020419 Oreochromis niloticus ENSONIG00000020419 I 0.890
ENSONIG00000021146 Oreochromis niloticus ENSONIG00000021146 I 0.890
BHLHE23 Ornithorhynchus anatinus ENSOANG00000004969 I 0.890
BHLHE22 Oryctolagus cuniculus ENSOCUG00000012968 I 0.914
bhlhe22 Oryzias latipes ENSORLG00000008625 I 0.890
bhlhe23 Oryzias latipes ENSORLG00000009742 I 0.890
BHLHE22 Otolemur garnettii ENSOGAG00000034883 I 0.914
ENSOARG00000011555 Ovis aries ENSOARG00000011555 I 0.888
ENSOARG00000016973 Ovis aries ENSOARG00000016973 I 0.890
BHLHE23 Pan troglodytes ENSPTRG00000013728 I 0.914
ENSPANG00000014258 Papio anubis ENSPANG00000014258 I 0.890
ENSPANG00000006045 Papio anubis ENSPANG00000006045 I 0.914
PHUM507440 Pediculus humanus PHUM507440 I 0.890
ENSPFOG00000020723 Poecilia formosa ENSPFOG00000020723 I 0.890
ENSPFOG00000020648 Poecilia formosa ENSPFOG00000020648 I 0.890
Pvit_14990 Pogona vitticeps Pvit_14990 I 0.890
ENSPPYG00000018628 Pongo abelii ENSPPYG00000018628 I 0.914
BHLHE23 Procavia capensis ENSPCAG00000008163 I 0.890
Bhlhe23 Rattus norvegicus ENSRNOG00000010312 I 0.890
Bhlhe22 Rattus norvegicus ENSRNOG00000021745 I 0.914
Sakowv30001655m.g Saccoglossus kowalevskii Sakowv30001655m.g I 0.914
ENSSHAG00000008128 Sarcophilus harrisii ENSSHAG00000008128 I 0.890
SSLN_0001887701 Schistocephalus solidus SSLN_0001887701 I 0.844
SCUD_0001512501 Schistosoma curassoni SCUD_0001512501 I 0.914
A_00716 Schistosoma haematobium A_00716 I 0.914
Sjc_0013770 Schistosoma japonicum Sjc_0013770 I 0.914
Smp_000620 Schistosoma mansoni Smp_000620 I 0.914
SMRZ_0001201801 Schistosoma margrebowiei SMRZ_0001201801 I 0.914
SMTD_0000281901 Schistosoma mattheei SMTD_0000281901 I 0.914
SROB_0002375401 Schistosoma rodhaini SROB_0002375401 I 0.914
SMU15011543 Schmidtea mediterranea SMU15011543 I 0.890
SINV14285 Solenopsis invicta SINV14285 I 0.914
SPER_0002141801 Spirometra erinaceieuropaei SPER_0002141801 I 0.844
SPER_0000692601 Spirometra erinaceieuropaei SPER_0000692601 I 0.844
SPER_0000128301 Spirometra erinaceieuropaei SPER_0000128301 I 0.844
SMAR007739 Strigamia maritima SMAR007739 I 0.914
SPU_026601 Strongylocentrotus purpuratus SPU_026601 I 0.890
SPU_004028 Strongylocentrotus purpuratus SPU_004028 I 0.890
BHLHE22 Sus scrofa ENSSSCG00000006222 I 0.914
bhlhe23 Takifugu rubripes ENSTRUG00000005237 I 0.890
bhlhe22 Takifugu rubripes ENSTRUG00000007963 I 0.890
bhlhe22 Takifugu rubripes ENSTRUG00000003506 I 0.890
tetur13g02560 Tetranychus urticae tetur13g02560 I 0.890
bhlhe22 Tetraodon nigroviridis ENSTNIG00000012697 I 0.890
bhlhe23 Tetraodon nigroviridis ENSTNIG00000017879 I 0.890
TC014712 Tribolium castaneum TC014712 I 0.914
TRE_0001403601 Trichobilharzia regenti TRE_0001403601 I 0.914
bhlhe22 Xenopus tropicalis XB-GENE-6457792 I 0.890
bhlhe23 Xenopus tropicalis XB-GENE-1018550 I 0.890
ENSXMAG00000019916 Xiphophorus maculatus ENSXMAG00000019916 I 0.890
ENSXMAG00000020159 Xiphophorus maculatus ENSXMAG00000020159 I 0.890