BHLHE23 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000125533 T034280_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
BHLHE23
M02784_2.00		 Homo sapiens
RVCATATGBY
RVCATATGBY		 SELEX
Jolma et al.(2013)
BHLHE23_1		 (Direct) (Direct)
BHLHE23
M04108_2.00		 Homo sapiens
AVCATATGBY
RVCATATGBT		 SELEX
Yin et al.(2017)
BHLHE23_eDBD_HT-SELEX		 (Direct) (Direct)
BHLHE23
M04109_2.00		 Homo sapiens
AVCATATGBY
RVCATATGBT		 SELEX
Yin et al.(2017)
BHLHE23_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
BHLHE23
M04110_2.00		 Homo sapiens
RVCATATGBY
RVCATATGBY		 SELEX
Yin et al.(2017)
BHLHE23_FL_HT-SELEX		 (Direct) (Direct)
BHLHE23
M04111_2.00		 Homo sapiens
RVCATATGBY
RVCATATGBY		 SELEX
Yin et al.(2017)
BHLHE23_FL_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Bhlhe22
M01729_2.00 		Mus musculus
NVCATATGGN
NCCATATGBN		 PBM
Weirauch et al.(2014)
pTH5267 		0.914 0.963
BHLHE22
M02804_2.00 		Homo sapiens
NAVCATATGBTN
NAVCATATGBTN		 SELEX
Jolma et al.(2013)
BHLHE22_1 		0.914 0.963
BHLHE22
M04199_2.00 		Homo sapiens
AVCATATGBY
RVCATATGBT		 SELEX
Yin et al.(2017)
BHLHE22_eDBD_HT-SELEX 		0.914 0.963
BHLHE22
M04200_2.00 		Homo sapiens
AVCATATGBY
RVCATATGBT		 SELEX
Yin et al.(2017)
BHLHE22_eDBD_Methyl-HT-SELEX 		0.914 0.963
Oli
M03618_2.00 		Drosophila melanogaster
AMCATATGKY
RMCATATGKT		 SELEX
Nitta et al.(2015)
Oli_1 		0.890 0.926
Oli
M05985_2.00 		Drosophila melanogaster
SACCATATGKY
RMCATATGGTS		 B1H
Zhu et al.(2011)
Oli_da_SANGER_5_1_FBgn0032651 		0.890 0.926
Oli
M05986_2.00 		Drosophila melanogaster
AHSBNRCCATMTGKY
RMCAKATGGYNVSDT		 B1H
Zhu et al.(2011)
Oli_da_SANGER_5_2_FBgn0032651 		0.890 0.926
Oli
M05987_2.00 		Drosophila melanogaster
MCATCTGKY
RMCAGATGK		 B1H
Zhu et al.(2011)
Oli_da_SANGER_5_3_FBgn0032651 		0.890 0.926
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000359371 bHLH 101 154
ENSP00000480998 bHLH 117 170

Links

Other bHLH family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

147 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action