CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ARNTL
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000133794
T034285_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19. [provided by RefSeq, Oct 2021]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
ARNTL
M02787_2.00
Homo sapiens
GTCACGTGAC
GTCACGTGAC
SELEX
Jolma et al.(2013)
ARNTL_1
(Direct)
(Direct)
ARNTL
M04124_2.00
Homo sapiens
RDCACGTGHN
NDCACGTGHY
SELEX
Yin et al.(2017)
ARNTL_eDBD_HT-SELEX
(Direct)
(Direct)
ARNTL
M04125_2.00
Homo sapiens
NDCACRTGHY
RDCAYGTGHN
SELEX
Yin et al.(2017)
ARNTL_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
ARNTL
M08725_2.00
Homo sapiens
NVDCACGTGBN
NVCACGTGHBN
Misc
Kulakovskiy et al.(2013)
BMAL1_HUMAN.H11MO.0.A
(Direct)
(Direct)
ARNTL
M09841_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BMAL1_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Arntl
M01751_2.00
Mus musculus
NCACGTGAYN
NRTCACGTGN
PBM
Weirauch et al.(2014)
pTH5064
0.914
1.000
Arntl
M08776_2.00
Mus musculus
VCACGTGMN
NKCACGTGB
Misc
Kulakovskiy et al.(2013)
BMAL1_MOUSE.H11MO.0.A
0.501
1.000
Arntl
M09478_2.00
Mus musculus
CACGTGNN
NNCACGTG
Misc
Heinz et al.(2010)
Liver-Bmal1_GSE39860
0.576
1.000
Arntl
M09889_2.00
Rattus norvegicus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BMAL1_01
0.914
1.000
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000374357
bHLH
73
126
AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLR
ENSP00000384517
bHLH
73
126
AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLR
ENSP00000385581
bHLH
30
83
AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLR
ENSP00000385897
bHLH
71
124
AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLR
ENSP00000385915
bHLH
30
83
AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLR
ENSP00000431488
bHLH
73
100
AREAHSQIEKRRRDKMNSFIDELASLVP
ENSP00000433571
bHLH
73
126
AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLR
ENSP00000434263
bHLH
30
46
AREAHSQIEKRRRDKMN
ENSP00000436313
bHLH
30
83
AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLR
ENSP00000436721
bHLH
30
72
AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVL
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
97 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy