CLOCK (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000134852 T034288_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
CLOCK
M02789_2.00		 Homo sapiens
DACACGTGYH
DRCACGTGTH		 SELEX
Jolma et al.(2013)
CLOCK_1		 (Direct) (Direct)
CLOCK
M04129_2.00		 Homo sapiens
NMCACGTGYN
NRCACGTGKN		 SELEX
Yin et al.(2017)
CLOCK_eDBD_HT-SELEX		 (Direct) (Direct)
CLOCK
M04130_2.00		 Homo sapiens
NRCRCRTGBH
DVCAYGYGYN		 SELEX
Yin et al.(2017)
CLOCK_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
CLOCK
M08728_2.00		 Homo sapiens
DBBBCAYKTGNNHB
VDNNCAMRTGVVVH		 Misc
Kulakovskiy et al.(2013)
CLOCK_HUMAN.H11MO.0.C		 (Direct) (Direct)
CLOCK
M09849_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CLOCK_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Clock
M01735_2.00 		Mus musculus
NNCAYRTGNN
NNCAYRTGNN		 PBM
Weirauch et al.(2014)
pTH5056 		0.914 1.000
Clock
M08760_2.00 		Mus musculus
DBBBCAYKTGNNHB
VDNNCAMRTGVVVH		 Misc
Kulakovskiy et al.(2013)
CLOCK_MOUSE.H11MO.0.C 		0.914 1.000
Clock
M09473_2.00 		Mus musculus
CACGTGNN
NNCACGTG		 Misc
Heinz et al.(2010)
Liver-Clock_GSE39860 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000308741 bHLH 35 85
ENSP00000370723 bHLH 35 85
ENSP00000396649 bHLH 35 85
ENSP00000426983 bHLH 35 85

Links

Other bHLH family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

78 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action