HEY2 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000135547 T034289_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HEY2
M02790_2.00		 Homo sapiens
GRCACGTGNV
BNCACGTGYC		 SELEX
Jolma et al.(2013)
HEY2_1		 (Direct) (Direct)
HEY2
M02791_2.00		 Homo sapiens
GVCACGTGYN
NRCACGTGBC		 SELEX
Jolma et al.(2013)
HEY2_2		 (Direct) (Direct)
HEY2
M04131_2.00		 Homo sapiens
NVCRCGYGVN
NBCRCGYGBN		 SELEX
Yin et al.(2017)
HEY2_eDBD_HT-SELEX		 (Direct) (Direct)
HEY2
M04132_2.00		 Homo sapiens
NVCRCGYRVN
NBYRCGYGBN		 SELEX
Yin et al.(2017)
HEY2_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
HEY2
M04133_2.00		 Homo sapiens
NVCACGTGVN
NBCACGTGBN		 SELEX
Yin et al.(2017)
HEY2_FL_HT-SELEX		 (Direct) (Direct)
HEY2
M04134_2.00		 Homo sapiens
NVCRCGYGSN
NSCRCGYGBN		 SELEX
Yin et al.(2017)
HEY2_FL_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hey2
M01722_2.00 		Mus musculus
RCACGTGNN
NNCACGTGY		 PBM
Weirauch et al.(2014)
pTH5102 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000357348 bHLH 49 104
ENSP00000357349 bHLH 3 58

Links

Other bHLH family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

164 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action