MYC (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000136997 T034290_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MYC
M07799_2.00
Homo sapiens
VNSCACGTGG

CCACGTGSNB
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_CMYC_Stanford
(Direct) (Direct)
MYC
M07800_2.00
Homo sapiens
NNSCACGTGGB

VCCACGTGSNN
ChIP-seq
Gerstein et al.(2012)
HepG2_CMYC_UT-A
(Direct) (Direct)
MYC
M07801_2.00
Homo sapiens
VNVCACGTGGN

NCCACGTGBNB
ChIP-seq
Gerstein et al.(2012)
K562_CMYC_Stanford
(Direct) (Direct)
MYC
M07802_2.00
Homo sapiens
VSCRCGTGBNB

VNVCACGYGSB
ChIP-seq
Gerstein et al.(2012)
K562_CMYC_UT-A
(Direct) (Direct)
MYC
M07803_2.00
Homo sapiens
CACGTGSH

DSCACGTG
ChIP-seq
Gerstein et al.(2012)
MCF-7_CMYC_UT-A
(Direct) (Direct)
MYC
M07804_2.00
Homo sapiens
NSCACGTGKBN

NVMCACGTGSN
ChIP-seq
Gerstein et al.(2012)
NB4_CMYC_Stanford
(Direct) (Direct)
MYC
M08054_2.00
Homo sapiens
NNSCACGTGGNN

NNCCACGTGSNN
ChIP-seq
Mathelier et al.(2014)
MA0147.3
(Direct) (Direct)
MYC
M08729_2.00
Homo sapiens
VNVCACRTGGN

NCCAYGTGBNB
Misc
Kulakovskiy et al.(2013)
MYC_HUMAN.H11MO.0.A
(Direct) (Direct)
MYC
M09457_2.00
Homo sapiens
CACGTGSN

NSCACGTG
Misc
Heinz et al.(2010)
LNCAP-cMyc_Unpublished
(Direct) (Direct)
MYC
M09850_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_01
(Direct) (Direct)
MYC
M09851_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_02
(Direct) (Direct)
MYC
M09852_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_Q3
(Direct) (Direct)
MYC
M09853_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_Q6_01
(Direct) (Direct)
MYC
M09854_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MYC_02
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000367207 bHLH 355 407
ENSP00000367207 bHLH 419 437
ENSP00000430235 bHLH 369 421
ENSP00000430235 bHLH 433 451
ENSP00000478887 bHLH 370 422
ENSP00000478887 bHLH 434 452
ENSP00000479618 bHLH 370 422
ENSP00000479618 bHLH 434 452

Links

Other bHLH family TFs
Other Homo sapiens TFs

23 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
MYC Gorilla gorilla ENSGGOG00000012135 I 0.914
MYC Pan troglodytes ENSPTRG00000020581 I 0.914
MYC Microcebus murinus ENSMICG00000014990 I 0.898
ENSCPOG00000003326 Cavia porcellus ENSCPOG00000003326 I 0.898
MYC Myotis lucifugus ENSMLUG00000026933 I 0.898
Myotis_brandtii_MYC_10012350 Myotis brandtii Myotis_brandtii_MYC_10012350 I 0.898
myc Xenopus tropicalis XB-GENE-6052814 I 0.861
ENSPANG00000010418 Papio anubis ENSPANG00000010418 I 0.846
Myc Rattus norvegicus ENSRNOG00000004500 I 0.846
MYC Sorex araneus ENSSARG00000010372 I 0.846
ENSMMUP00000019164 Macaca fascicularis ENSMMUP00000019164 I 0.846
MYC Tupaia belangeri ENSTBEG00000005715 I 0.846
MYC Oryctolagus cuniculus ENSOCUG00000014289 I 0.846
MYC Macaca mulatta ENSMMUG00000014601 I 0.846
ENSCSAG00000010109 Chlorocebus sabaeus ENSCSAG00000010109 I 0.846
MYC Callithrix jacchus ENSCJAG00000012620 I 0.846
MYC Canis familiaris ENSCAFG00000001086 I 0.846
MYC Dasypus novemcinctus ENSDNOG00000048399 I 0.846
MYC Felis catus ENSFCAG00000025438 I 0.846
ENSMPUG00000001327 Mustela putorius furo ENSMPUG00000001327 I 0.846
ENSAMEG00000014717 Ailuropoda melanoleuca ENSAMEG00000014717 I 0.846
ENSNLEG00000005570 Nomascus leucogenys ENSNLEG00000005570 I 0.846