CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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MYC
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000136997
T034290_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
MYC
M07799_2.00
Homo sapiens
VNSCACGTGG
CCACGTGSNB
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_CMYC_Stanford
(Direct)
(Direct)
MYC
M07800_2.00
Homo sapiens
NNSCACGTGGB
VCCACGTGSNN
ChIP-seq
Gerstein et al.(2012)
HepG2_CMYC_UT-A
(Direct)
(Direct)
MYC
M07801_2.00
Homo sapiens
VNVCACGTGGN
NCCACGTGBNB
ChIP-seq
Gerstein et al.(2012)
K562_CMYC_Stanford
(Direct)
(Direct)
MYC
M07802_2.00
Homo sapiens
VSCRCGTGBNB
VNVCACGYGSB
ChIP-seq
Gerstein et al.(2012)
K562_CMYC_UT-A
(Direct)
(Direct)
MYC
M07803_2.00
Homo sapiens
CACGTGSH
DSCACGTG
ChIP-seq
Gerstein et al.(2012)
MCF-7_CMYC_UT-A
(Direct)
(Direct)
MYC
M07804_2.00
Homo sapiens
NSCACGTGKBN
NVMCACGTGSN
ChIP-seq
Gerstein et al.(2012)
NB4_CMYC_Stanford
(Direct)
(Direct)
MYC
M08054_2.00
Homo sapiens
NNSCACGTGGNN
NNCCACGTGSNN
ChIP-seq
Mathelier et al.(2014)
MA0147.3
(Direct)
(Direct)
MYC
M08729_2.00
Homo sapiens
VNVCACRTGGN
NCCAYGTGBNB
Misc
Kulakovskiy et al.(2013)
MYC_HUMAN.H11MO.0.A
(Direct)
(Direct)
MYC
M09457_2.00
Homo sapiens
CACGTGSN
NSCACGTG
Misc
Heinz et al.(2010)
LNCAP-cMyc_Unpublished
(Direct)
(Direct)
MYC
M09850_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_01
(Direct)
(Direct)
MYC
M09851_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_02
(Direct)
(Direct)
MYC
M09852_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_Q3
(Direct)
(Direct)
MYC
M09853_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CMYC_Q6_01
(Direct)
(Direct)
MYC
M09854_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MYC_02
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000367207
bHLH
355
407
KRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQ
ENSP00000367207
bHLH
419
437
LLRKRREQLKHKLEQLRNS
ENSP00000430235
bHLH
369
421
KRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQ
ENSP00000430235
bHLH
433
451
LLRKRREQLKHKLEQLRNS
ENSP00000478887
bHLH
370
422
KRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQ
ENSP00000478887
bHLH
434
452
LLRKRREQLKHKLEQLRNS
ENSP00000479618
bHLH
370
422
KRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQ
ENSP00000479618
bHLH
434
452
LLRKRREQLKHKLEQLRNS
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
23 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy