CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ASCL1
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000139352
T034291_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
ASCL1
M04135_2.00
Homo sapiens
NRCASSTGYN
NRCASSTGYN
SELEX
Yin et al.(2017)
ASCL1_eDBD_HT-SELEX
(Direct)
(Direct)
ASCL1
M04136_2.00
Homo sapiens
NRCAGCTGYN
NRCAGCTGYN
SELEX
Yin et al.(2017)
ASCL1_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
ASCL1
M08055_2.00
Homo sapiens
NNRGCAGCTGSNN
NNSCAGCTGCYNN
ChIP-seq
Mathelier et al.(2014)
MA1100.1
(Direct)
(Direct)
ASCL1
M08730_2.00
Homo sapiens
NNVCASCTGCYBYN
NRVRGCAGSTGBNN
Misc
Kulakovskiy et al.(2013)
ASCL1_HUMAN.H11MO.0.A
(Direct)
(Direct)
ASCL1
M09855_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MASH1_Q6_01
(Direct)
(Direct)
ASCL1
M09856_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MASH1_Q6_02
(Direct)
(Direct)
ASCL1
M09857_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MASH1_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Ascl1
M08748_2.00
Mus musculus
BHSCASCTGCYBBN
NVVRGCAGSTGSDV
Misc
Kulakovskiy et al.(2013)
ASCL1_MOUSE.H11MO.0.A
0.914
1.000
Ascl1
M09464_2.00
Mus musculus
NVCABCTGBBNN
NNVVCAGVTGBN
Misc
Heinz et al.(2010)
NeuralTubes-Ascl1_GSE55840
0.914
1.000
Ascl2
M00117_2.00
Mus musculus
NVCABVTGBN
NVCABVTGBN
PBM
Badis et al.(2009)
Ascl2_2654
0.871
0.880
Ascl2
M02814_2.00
Mus musculus
RRCAGCTGYY
RRCAGCTGYY
SELEX
Jolma et al.(2013)
Ascl2_1
0.871
0.880
Ascl2
M08744_2.00
Mus musculus
RGCAGSTGB
VCASCTGCY
Misc
Kulakovskiy et al.(2013)
ASCL2_MOUSE.H11MO.0.C
0.871
0.880
ASCL2
M04207_2.00
Homo sapiens
NRCAGCTGYN
NRCAGCTGYN
SELEX
Yin et al.(2017)
ASCL2_eDBD_HT-SELEX
0.871
0.860
ASCL2
M04209_2.00
Homo sapiens
VCACRACGCD
HGCGTYGTGB
SELEX
Yin et al.(2017)
ASCL2_FL_HT-SELEX_1
0.871
0.860
ASCL2
M04210_2.00
Homo sapiens
NRCAGCTGYN
NRCAGCTGYN
SELEX
Yin et al.(2017)
ASCL2_FL_HT-SELEX_2
0.871
0.860
ASCL2
M04208_2.00
Homo sapiens
NRCAGCTGYN
NRCAGCTGYN
SELEX
Yin et al.(2017)
ASCL2_eDBD_Methyl-HT-SELEX
0.871
0.860
ASCL2
M04211_2.00
Homo sapiens
VRCAGCTGYB
VRCAGCTGYB
SELEX
Yin et al.(2017)
ASCL2_FL_Methyl-HT-SELEX
0.871
0.860
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000266744
bHLH
121
171
ARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQ
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
87 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy