CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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HEYL
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000163909
T034304_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hey2
M01722_2.00
Mus musculus
RCACGTGNN
NNCACGTGY
PBM
Weirauch et al.(2014)
pTH5102
0.870
0.909
HEY2
M02790_2.00
Homo sapiens
GRCACGTGNV
BNCACGTGYC
SELEX
Jolma et al.(2013)
HEY2_1
0.870
0.909
HEY2
M02791_2.00
Homo sapiens
GVCACGTGYN
NRCACGTGBC
SELEX
Jolma et al.(2013)
HEY2_2
0.870
0.909
HEY2
M04131_2.00
Homo sapiens
NVCRCGYGVN
NBCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_HT-SELEX
0.870
0.909
HEY2
M04133_2.00
Homo sapiens
NVCACGTGVN
NBCACGTGBN
SELEX
Yin et al.(2017)
HEY2_FL_HT-SELEX
0.870
0.909
HEY2
M04132_2.00
Homo sapiens
NVCRCGYRVN
NBYRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_Methyl-HT-SELEX
0.870
0.909
HEY2
M04134_2.00
Homo sapiens
NVCRCGYGSN
NSCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_FL_Methyl-HT-SELEX
0.870
0.909
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000361943
bHLH
44
99
RKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLH
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
165 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy