CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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HEY1
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000164683
T034307_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HEY1
M02793_2.00
Homo sapiens
SVCACGTGYC
GRCACGTGBS
SELEX
Jolma et al.(2013)
HEY1_1
(Direct)
(Direct)
HEY1
M04152_2.00
Homo sapiens
NRCACGTGVV
BBCACGTGYN
SELEX
Yin et al.(2017)
HEY1_eDBD_HT-SELEX
(Direct)
(Direct)
HEY1
M04153_2.00
Homo sapiens
NRCRCGYGVV
BBCRCGYGYN
SELEX
Yin et al.(2017)
HEY1_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
HEY1
M04154_2.00
Homo sapiens
NRCRCGYGVV
BBCRCGYGYN
SELEX
Yin et al.(2017)
HEY1_FL_HT-SELEX
(Direct)
(Direct)
HEY1
M04155_2.00
Homo sapiens
NDCRCGYRSN
NSYRCGYGHN
SELEX
Yin et al.(2017)
HEY1_FL_Methyl-HT-SELEX
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hey2
M01722_2.00
Mus musculus
RCACGTGNN
NNCACGTGY
PBM
Weirauch et al.(2014)
pTH5102
0.860
0.945
HEY2
M02790_2.00
Homo sapiens
GRCACGTGNV
BNCACGTGYC
SELEX
Jolma et al.(2013)
HEY2_1
0.860
0.945
HEY2
M02791_2.00
Homo sapiens
GVCACGTGYN
NRCACGTGBC
SELEX
Jolma et al.(2013)
HEY2_2
0.860
0.945
HEY2
M04131_2.00
Homo sapiens
NVCRCGYGVN
NBCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_HT-SELEX
0.860
0.945
HEY2
M04133_2.00
Homo sapiens
NVCACGTGVN
NBCACGTGBN
SELEX
Yin et al.(2017)
HEY2_FL_HT-SELEX
0.860
0.945
HEY2
M04132_2.00
Homo sapiens
NVCRCGYRVN
NBYRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_Methyl-HT-SELEX
0.860
0.945
HEY2
M04134_2.00
Homo sapiens
NVCRCGYGSN
NSCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_FL_Methyl-HT-SELEX
0.860
0.945
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000338272
bHLH
50
109
RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH
ENSP00000346761
bHLH
50
105
RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLH
ENSP00000429705
bHLH
12
67
RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLH
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
185 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
ENSLACG00000015540
Latimeria chalumnae
ENSLACG00000015540
I
0.914
ENSGMOG00000017811
Gadus morhua
ENSGMOG00000017811
I
0.914
HEY1
Loxodonta africana
ENSLAFG00000011488
I
0.914
HEY1
Tetraodon nigroviridis
ENSTNIG00000018401
I
0.914
HEY1
Sus scrofa
ENSSSCG00000006159
I
0.914
ENSSTOG00000023191
Ictidomys tridecemlineatus
ENSSTOG00000023191
I
0.914
ENSGMOG00000013488
Gadus morhua
ENSGMOG00000013488
I
0.914
HEY1
Gorilla gorilla
ENSGGOG00000009960
I
0.914
ENSFALG00000008605
Ficedula albicollis
ENSFALG00000008605
I
0.914
HEY1
Equus caballus
ENSECAG00000017010
I
0.914
HEY1
Felis catus
ENSFCAG00000025542
I
0.914
HEY1
Takifugu rubripes
ENSTRUG00000013573
I
0.914
HEY1
Gasterosteus aculeatus
ENSGACG00000008712
I
0.914
ENSSHAG00000017958
Sarcophilus harrisii
ENSSHAG00000017958
I
0.914
Hey1
Rattus norvegicus
ENSRNOG00000011593
I
0.914
ENSPANG00000018687
Papio anubis
ENSPANG00000018687
I
0.914
ENSPFOG00000001913
Poecilia formosa
ENSPFOG00000001913
I
0.914
ENSOARG00000008063
Ovis aries
ENSOARG00000008063
I
0.914
HEY1
Otolemur garnettii
ENSOGAG00000007210
I
0.914
ENSONIG00000003087
Oreochromis niloticus
ENSONIG00000003087
I
0.914
HEY1
Oryzias latipes
ENSORLG00000008268
I
0.914
ENSNLEG00000002239
Nomascus leucogenys
ENSNLEG00000002239
I
0.914
Hey1
Mus musculus
ENSMUSG00000040289
I
0.914
HEY1
Pan troglodytes
ENSPTRG00000020364
I
0.914
HEY1
Macaca mulatta
ENSMMUG00000002740
I
0.914
HEY1
Monodelphis domestica
ENSMODG00000006648
I
0.914
ENSPSIG00000003791
Pelodiscus sinensis
ENSPSIG00000003791
I
0.914
ENSPPYG00000018693
Pongo abelii
ENSPPYG00000018693
I
0.914
ENSMPUG00000001859
Mustela putorius furo
ENSMPUG00000001859
I
0.914
HEY1
Dasypus novemcinctus
ENSDNOG00000031981
I
0.914
hey1
Gasterosteus aculeatus
ENSGACG00000003436
I
0.914
HEY1
Bos taurus
ENSBTAG00000015717
I
0.914
Gfo_R007552
Geospiza fortis
Gfo_R007552
I
0.914
Myotis_brandtii_HEY1_10021379
Myotis brandtii
Myotis_brandtii_HEY1_10021379
I
0.914
ENSP00000338272
Macaca fascicularis
ENSP00000338272
I
0.914
ENSCSAG00000013410
Chlorocebus sabaeus
ENSCSAG00000013410
I
0.914
Brh_R005579
Buceros rhinoceros
Brh_R005579
I
0.914
HEY1
Callithrix jacchus
ENSCJAG00000000477
I
0.914
HEY1
Cavia porcellus
ENSCPOG00000008527
I
0.914
HEY1
Canis familiaris
ENSCAFG00000008391
I
0.914
Pvit_00065
Pogona vitticeps
Pvit_00065
I
0.914
Ogr14041
Ophisaurus gracilis
Ogr14041
I
0.914
Afo_R005157
Aptenodytes forsteri
Afo_R005157
I
0.914
hey1.S
Xenopus laevis
XB-GENE-865637
I
0.914
hey1
Xenopus tropicalis
XB-GENE-486694
I
0.914
hey1
Danio rerio
ENSDARG00000070538
I
0.914
hey1
Tetraodon nigroviridis
ENSTNIG00000017785
I
0.911
hey1
Takifugu rubripes
ENSTRUG00000014561
I
0.911
heyl
Takifugu rubripes
ENSTRUG00000003399
I
0.894
CapteG228069
Capitella teleta
CapteG228069
I
0.894
ENSONIG00000004726
Oreochromis niloticus
ENSONIG00000004726
I
0.894
ENSLOCG00000001853
Lepisosteus oculatus
ENSLOCG00000001853
I
0.894
ENSAMXG00000011237
Astyanax mexicanus
ENSAMXG00000011237
I
0.894
ENSPFOG00000015536
Poecilia formosa
ENSPFOG00000015536
I
0.894
LDEC001043
Leptinotarsa decemlineata
LDEC001043
I
0.894
YQE_09192
Dendroctonus ponderosae
YQE_09192
I
0.894
heyl
Oryzias latipes
ENSORLG00000013651
I
0.894
heyl
Tetraodon nigroviridis
ENSTNIG00000009228
I
0.894
HEYL
Felis catus
ENSFCAG00000010963
I
0.894
ENSXMAG00000006950
Xiphophorus maculatus
ENSXMAG00000006950
I
0.894
heyl
Danio rerio
ENSDARG00000055798
I
0.894
LotgiG171867
Lottia gigantea
LotgiG171867
I
0.894
heyl
Gasterosteus aculeatus
ENSGACG00000007492
I
0.894
ENSXMAG00000014241
Xiphophorus maculatus
ENSXMAG00000014241
I
0.894
TC001593
Tribolium castaneum
TC001593
I
0.894
ENSGMOG00000011084
Gadus morhua
ENSGMOG00000011084
I
0.894
ENSAMEG00000017517
Ailuropoda melanoleuca
ENSAMEG00000017517
I
0.889
ENSP00000338272-D1
Bos grunniens
ENSP00000338272-D1
I
0.889
HEY1
Microcebus murinus
ENSMICG00000001913
I
0.889
HEY1
Procavia capensis
ENSPCAG00000000598
I
0.889
HEY1
Oryctolagus cuniculus
ENSOCUG00000016568
I
0.889
HEY1
Tupaia belangeri
ENSTBEG00000010367
I
0.889
HEY1
Ochotona princeps
ENSOPRG00000003055
I
0.889
CGI_10018323
Crassostrea gigas
CGI_10018323
I
0.884
SPU_009465
Strongylocentrotus purpuratus
SPU_009465
I
0.884
Sakowv30023592m.g
Saccoglossus kowalevskii
Sakowv30023592m.g
I
0.884
Ocbimv22039104m.g
Octopus bimaculoides
Ocbimv22039104m.g
I
0.884
ISCW011251
Ixodes scapularis
ISCW011251
I
0.884
ENSLACG00000012215
Latimeria chalumnae
ENSLACG00000012215
I
0.884
Aqu1.218726
Amphimedon queenslandica
Aqu1.218726
I
0.881
DAPPUDRAFT_347250
Daphnia pulex
DAPPUDRAFT_347250
N
0.873
CapteG182542
Capitella teleta
CapteG182542
I
0.870
hey1
Oryzias latipes
ENSORLG00000012953
I
0.867
ENSAMXG00000011148
Astyanax mexicanus
ENSAMXG00000011148
N
0.867
ENSXMAG00000003593
Xiphophorus maculatus
ENSXMAG00000003593
I
0.867
ENSONIG00000002623
Oreochromis niloticus
ENSONIG00000002623
I
0.867
ENSPFOG00000014160
Poecilia formosa
ENSPFOG00000014160
I
0.867
HEYL
Tursiops truncatus
ENSTTRG00000014353
I
0.864
ENSP00000361943-D1
Bos grunniens
ENSP00000361943-D1
I
0.864
tetur01g03020
Tetranychus urticae
tetur01g03020
I
0.864
Cmyd_10005434
Chelonia mydas
Cmyd_10005434
I
0.864
PHUM454530
Pediculus humanus
PHUM454530
I
0.864
L798_14068
Zootermopsis nevadensis
L798_14068
I
0.864
ENSPPYG00000001505
Pongo abelii
ENSPPYG00000001505
I
0.864
Alligator_sinensis_CCG011017.1
Alligator sinensis
Alligator_sinensis_CCG011017.1
I
0.864
Heyl
Rattus norvegicus
ENSRNOG00000015318
I
0.864
ENSSSCG00000024651
Sus scrofa
ENSSSCG00000024651
I
0.864
HEYL
Pan troglodytes
ENSPTRG00000000574
I
0.864
ENSP00000361943
Macaca fascicularis
ENSP00000361943
I
0.864
ENSPANG00000006227
Papio anubis
ENSPANG00000006227
I
0.864
ENSOARG00000020088
Ovis aries
ENSOARG00000020088
I
0.864
HEYL
Gorilla gorilla
ENSGGOG00000008268
I
0.864
HEYL
Macaca mulatta
ENSMMUG00000018861
I
0.864
ENSCSAG00000001134
Chlorocebus sabaeus
ENSCSAG00000001134
I
0.864
ENSGALG00000021593
Gallus gallus
ENSGALG00000021593
I
0.864
HEYL
Dasypus novemcinctus
ENSDNOG00000010392
I
0.864
HEYL
Bos taurus
ENSBTAG00000008688
I
0.864
ENSCPOG00000000704
Cavia porcellus
ENSCPOG00000000704
I
0.864
HEYL
Loxodonta africana
ENSLAFG00000027563
I
0.864
PABPC4
Canis familiaris
ENSCAFG00000003081
I
0.864
ENSMPUG00000014412
Mustela putorius furo
ENSMPUG00000014412
I
0.864
ENSAPLG00000007121
Anas platyrhynchos
ENSAPLG00000007121
I
0.864
HEYL
Homo sapiens
ENSG00000163909
I
0.864
HEYL
Oryctolagus cuniculus
ENSOCUG00000000560
I
0.864
ENSFALG00000000542
Ficedula albicollis
ENSFALG00000000542
I
0.864
HEYL
Ornithorhynchus anatinus
ENSOANG00000010000
I
0.864
HEYL
Equus caballus
ENSECAG00000007220
I
0.864
HEYL
Otolemur garnettii
ENSOGAG00000030877
I
0.864
Heyl
Mus musculus
ENSMUSG00000032744
I
0.864
ENSAMEG00000011612
Ailuropoda melanoleuca
ENSAMEG00000011612
I
0.864
ENSDORG00000009001
Dipodomys ordii
ENSDORG00000009001
I
0.860
Alligator_sinensis_CCG009102.1
Alligator sinensis
Alligator_sinensis_CCG009102.1
I
0.860
ENSCSAG00000016312
Chlorocebus sabaeus
ENSCSAG00000016312
I
0.860
Afo_R005555
Aptenodytes forsteri
Afo_R005555
I
0.860
Aan_R009606
Calypte anna
Aan_R009606
I
0.860
HEY2
Equus caballus
ENSECAG00000014094
I
0.860
HEY2
Dasypus novemcinctus
ENSDNOG00000044967
I
0.860
hey2
Danio rerio
ENSDARG00000013441
I
0.860
ENSP00000357348-D1
Bos grunniens
ENSP00000357348-D1
I
0.860
Pvit_01735
Pogona vitticeps
Pvit_01735
I
0.860
ENSAPLG00000003195
Anas platyrhynchos
ENSAPLG00000003195
I
0.860
Ogr15033
Ophisaurus gracilis
Ogr15033
I
0.860
ENSAMXG00000018013
Astyanax mexicanus
ENSAMXG00000018013
I
0.860
ENSAMEG00000009592
Ailuropoda melanoleuca
ENSAMEG00000009592
I
0.860
HEY2
Anolis carolinensis
ENSACAG00000001813
I
0.860
hey2
Xenopus tropicalis
XB-GENE-485923
I
0.860
Myotis_brandtii_hey2_10035635
Myotis brandtii
Myotis_brandtii_hey2_10035635
I
0.860
HEY2
Bos taurus
ENSBTAG00000000919
I
0.860
HEY2
Callithrix jacchus
ENSCJAG00000003761
I
0.860
Cmyd_10006677
Chelonia mydas
Cmyd_10006677
I
0.860
HEY2
Cavia porcellus
ENSCPOG00000021417
I
0.860
HEY2
Erinaceus europaeus
ENSEEUG00000014040
I
0.860
ENSP00000357348
Macaca fascicularis
ENSP00000357348
I
0.860
Gfo_R016187
Geospiza fortis
Gfo_R016187
I
0.860
ENSCAFG00000032212
Canis familiaris
ENSCAFG00000032212
I
0.860
Brh_R011837
Buceros rhinoceros
Brh_R011837
I
0.860
HEY2
Homo sapiens
ENSG00000135547
D
0.860
HEY2
Macaca mulatta
ENSMMUG00000009491
I
0.860
HEY2
Pan troglodytes
ENSPTRG00000018574
I
0.860
ENSPSIG00000012495
Pelodiscus sinensis
ENSPSIG00000012495
I
0.860
Hey2
Rattus norvegicus
ENSRNOG00000013364
I
0.860
HEY2
Myotis lucifugus
ENSMLUG00000002617
I
0.860
HEY2
Echinops telfairi
ENSETEG00000007340
I
0.860
HEY2
Sorex araneus
ENSSARG00000011755
I
0.860
HEY2
Monodelphis domestica
ENSMODG00000017701
I
0.860
ENSPPYG00000016987
Pongo abelii
ENSPPYG00000016987
I
0.860
ENSOARG00000007915
Ovis aries
ENSOARG00000007915
I
0.860
HEY2
Otolemur garnettii
ENSOGAG00000027812
I
0.860
ENSOANG00000022119
Ornithorhynchus anatinus
ENSOANG00000022119
I
0.860
ENSNLEG00000013972
Nomascus leucogenys
ENSNLEG00000013972
I
0.860
ENSMPUG00000014531
Mustela putorius furo
ENSMPUG00000014531
I
0.860
Hey2
Mus musculus
ENSMUSG00000019789
D
0.860
HEY2
Meleagris gallopavo
ENSMGAG00000013281
I
0.860
ENSSHAG00000016487
Sarcophilus harrisii
ENSSHAG00000016487
I
0.860
HEY2
Loxodonta africana
ENSLAFG00000014208
I
0.860
HEY2
Taeniopygia guttata
ENSTGUG00000011792
I
0.860
ENSLACG00000006098
Latimeria chalumnae
ENSLACG00000006098
I
0.860
HEY2
Vicugna pacos
ENSVPAG00000010498
I
0.860
HEY2
Felis catus
ENSFCAG00000026914
I
0.860
HEY2
Tupaia belangeri
ENSTBEG00000008836
I
0.860
ENSLOCG00000017268
Lepisosteus oculatus
ENSLOCG00000017268
I
0.860
ENSFALG00000011461
Ficedula albicollis
ENSFALG00000011461
I
0.860
HEY2
Sus scrofa
ENSSSCG00000004223
I
0.860
ENSSTOG00000022371
Ictidomys tridecemlineatus
ENSSTOG00000022371
I
0.860
estExt_GenewiseH_1.C_4620016
Branchiostoma floridae
estExt_GenewiseH_1.C_4620016
I
0.857
HEY1
Anolis carolinensis
ENSACAG00000013410
I
0.846
ENSLOCG00000004692
Lepisosteus oculatus
ENSLOCG00000004692
I
0.846
ENSMEUG00000009781
Macropus eugenii
ENSMEUG00000009781
I
0.846
ENSMEUG00000007444
Macropus eugenii
ENSMEUG00000007444
I
0.840
ENSSHAG00000018213
Sarcophilus harrisii
ENSSHAG00000018213
I
0.840
CLEC011631
Cimex lectularius
CLEC011631
N
0.838
HEYL
Myotis lucifugus
ENSMLUG00000029490
I
0.838
HEY1
Taeniopygia guttata
ENSTGUG00000011633
N
0.777
HEY1
Meleagris gallopavo
ENSMGAG00000011620
I
0.272