TF Information

PTF1A *(Homo sapiens)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	ENSG00000168267	T034310_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
PTF1A M04156_2.00	Homo sapiens	AACAGCTGACRB	VYGTCAGCTGTT	SELEX Yin et al.(2017) PTF1A_eDBD_HT-SELEX	(Direct)	(Direct)
PTF1A M04157_2.00	Homo sapiens	AMCAGCTGACRB	VYGTCAGCTGKT	SELEX Yin et al.(2017) PTF1A_eDBD_Methyl-HT-SELEX	(Direct)	(Direct)
PTF1A M08736_2.00	Homo sapiens	SCAGCTGBYNBNNYYYHN	NDRRRNNVNRVCAGCTGS	Misc Kulakovskiy et al.(2013) PTF1A_HUMAN.H11MO.0.B	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Ptf1a M08757_2.00	Mus musculus	SCAGCTGBYNBNNYYYHN	NDRRRNNVNRVCAGCTGS	Misc Kulakovskiy et al.(2013) PTF1A_MOUSE.H11MO.0.A	0.914	1.000
Ptf1a M09470_2.00	Mus musculus	NVVCASSTGB	VCASSTGBBN	Misc Heinz et al.(2010) Panc1-Ptf1a_GSE47459	0.914	1.000
Fer1 M03620_2.00	Drosophila melanogaster	VDCASCTGHY	RDCAGSTGHB	SELEX Nitta et al.(2015) Fer1_1	0.894	0.865
Fer1 M05990_2.00	Drosophila melanogaster	HVCASMTGWCV	BGWCAKSTGBD	B1H Zhu et al.(2011) Fer1_da_SANGER_10_FBgn0037475	0.894	0.865
Fer1 M05991_2.00	Drosophila melanogaster	WYRHCAGCTGACG	CGTCAGCTGDYRW	B1H Zhu et al.(2011) Fer1_SANGER_5_FBgn0037475	0.894	0.865
For this family, TFs with SR scores > 0.838* will likely have a similar motif*