NPAS2 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000170485 T034312_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NPAS2
M04158_2.00		 Homo sapiens
NRCACGTGKH
DMCACGTGYN		 SELEX
Yin et al.(2017)
NPAS2_eDBD_HT-SELEX		 (Direct) (Direct)
NPAS2
M04159_2.00		 Homo sapiens
DVCRCRTGKH
DMCAYGYGBH		 SELEX
Yin et al.(2017)
NPAS2_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Npas2
M01731_2.00 		Mus musculus
NVCACGTGBN
NVCACGTGBN		 PBM
Weirauch et al.(2014)
pTH5457 		0.914 1.000
Npas2
M09468_2.00 		Mus musculus
VKCACRTGKM
KMCAYGTGMB		 Misc
Heinz et al.(2010)
Liver-NPAS2_GSE39860 		0.777 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000338283 bHLH 10 59
ENSP00000388528 bHLH 1 49
ENSP00000395265 bHLH 1 43
ENSP00000397595 bHLH 75 124

Links

Other bHLH family TFs
Other Homo sapiens TFs

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55 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action