CIS-BP Database: Catalog of Inferred Sequence Binding Preferences - Update
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MSC
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000178860
T034325_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
MSC
M02801_2.00
Homo sapiens
AACAGCTGTT
AACAGCTGTT
SELEX
Jolma et al.(2013)
MSC_1
(Direct)
(Direct)
MSC
M04183_2.00
Homo sapiens
NRMCAGMTGBYN
NRVCAKCTGKYN
SELEX
Yin et al.(2017)
MSC_eDBD_HT-SELEX_1
(Direct)
(Direct)
MSC
M04184_2.00
Homo sapiens
NRVCAYVTGBYN
NRVCABRTGBYN
SELEX
Yin et al.(2017)
MSC_eDBD_HT-SELEX_2
(Direct)
(Direct)
MSC
M04185_2.00
Homo sapiens
NRVCAGCTGBBN
NVVCAGCTGBYN
SELEX
Yin et al.(2017)
MSC_eDBD_Methyl-HT-SELEX_1
(Direct)
(Direct)
MSC
M04186_2.00
Homo sapiens
BRMCATATGKYV
BRMCATATGKYV
SELEX
Yin et al.(2017)
MSC_eDBD_Methyl-HT-SELEX_2
(Direct)
(Direct)
MSC
M04187_2.00
Homo sapiens
NRMCAGCTGBYV
BRVCAGCTGKYN
SELEX
Yin et al.(2017)
MSC_FL_HT-SELEX_1
(Direct)
(Direct)
MSC
M04188_2.00
Homo sapiens
BRMCATATGKYN
NRMCATATGKYV
SELEX
Yin et al.(2017)
MSC_FL_HT-SELEX_2
(Direct)
(Direct)
MSC
M04189_2.00
Homo sapiens
BRACAGCTGTYV
BRACAGCTGTYV
SELEX
Yin et al.(2017)
MSC_FL_Methyl-HT-SELEX_1
(Direct)
(Direct)
MSC
M04190_2.00
Homo sapiens
BRMCATATGKYV
BRMCATATGKYV
SELEX
Yin et al.(2017)
MSC_FL_Methyl-HT-SELEX_2
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Msc
M01730_2.00
Mus musculus
NVCRKMYGBN
NVCRKMYGBN
PBM
Weirauch et al.(2014)
pTH5112
0.914
1.000
Tcf21
M01746_2.00
Mus musculus
RMCAKMTGK
MCAKMTGKY
PBM
Weirauch et al.(2014)
pTH5087
0.914
0.981
Tcf21
M02819_2.00
Mus musculus
VNAACAGCTGTTVN
NBAACAGCTGTTNB
SELEX
Jolma et al.(2013)
Tcf21_1
0.914
0.981
TCF21
M04092_2.00
Homo sapiens
BAACAGCTGBYN
NRVCAGCTGTTV
SELEX
Yin et al.(2017)
TCF21_eDBD_HT-SELEX_1
0.914
0.981
TCF21
M04093_2.00
Homo sapiens
NRCCATATGKYV
BRMCATATGGYN
SELEX
Yin et al.(2017)
TCF21_eDBD_HT-SELEX_2
0.914
0.981
TCF21
M04094_2.00
Homo sapiens
BAACAGCTGTYV
BRACAGCTGTTV
SELEX
Yin et al.(2017)
TCF21_eDBD_Methyl-HT-SELEX_1
0.914
0.981
TCF21
M04095_2.00
Homo sapiens
BACCATATGKYV
BRMCATATGGTV
SELEX
Yin et al.(2017)
TCF21_eDBD_Methyl-HT-SELEX_2
0.914
0.981
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000321445
bHLH
108
160
QRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLR
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
188 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
ENSPFOG00000010821
Poecilia formosa
ENSPFOG00000010821
I
0.914
ENSPPYG00000017022
Pongo abelii
ENSPPYG00000017022
I
0.914
ENSPCAG00000006459
Procavia capensis
ENSPCAG00000006459
I
0.914
MSC
Procavia capensis
ENSPCAG00000004330
I
0.914
ENSPANG00000022301
Papio anubis
ENSPANG00000022301
I
0.914
ENSPANG00000024238
Papio anubis
ENSPANG00000024238
I
0.914
ENSPPYG00000018665
Pongo abelii
ENSPPYG00000018665
I
0.914
ENSPSIG00000003604
Pelodiscus sinensis
ENSPSIG00000003604
I
0.914
TCF21
Pteropus vampyrus
ENSPVAG00000009085
I
0.914
Tcf21
Rattus norvegicus
ENSRNOG00000016700
I
0.914
MSC
Pteropus vampyrus
ENSPVAG00000009083
I
0.914
MSC
Pan troglodytes
ENSPTRG00000020339
I
0.914
TCF21
Pan troglodytes
ENSPTRG00000018622
I
0.914
tcf21
Oryzias latipes
ENSORLG00000016491
I
0.914
ENSONIG00000000446
Oreochromis niloticus
ENSONIG00000000446
I
0.914
ENSNLEG00000011452
Nomascus leucogenys
ENSNLEG00000011452
I
0.914
ENSNLEG00000014647
Nomascus leucogenys
ENSNLEG00000014647
I
0.914
Tcf21
Mus musculus
ENSMUSG00000045680
D
0.914
Msc
Mus musculus
ENSMUSG00000025930
D
0.914
ENSMPUG00000010593
Mustela putorius furo
ENSMPUG00000010593
I
0.914
ENSMPUG00000014798
Mustela putorius furo
ENSMPUG00000014798
I
0.914
TCF21
Ornithorhynchus anatinus
ENSOANG00000013098
I
0.914
ENSOARG00000004844
Ovis aries
ENSOARG00000004844
I
0.914
MSC
Otolemur garnettii
ENSOGAG00000013827
I
0.914
TCF21
Otolemur garnettii
ENSOGAG00000034073
I
0.914
TCF21
Oryctolagus cuniculus
ENSOCUG00000017761
I
0.914
MSC
Oryctolagus cuniculus
ENSOCUG00000007208
I
0.914
ENSOARG00000014623
Ovis aries
ENSOARG00000014623
I
0.914
ENSSHAG00000002801
Sarcophilus harrisii
ENSSHAG00000002801
I
0.914
ENSSHAG00000004870
Sarcophilus harrisii
ENSSHAG00000004870
I
0.914
ENSBTAP00000052463-D1
Bos grunniens
ENSBTAP00000052463-D1
I
0.914
ENSP00000321445
Macaca fascicularis
ENSP00000321445
I
0.914
ENSBTAP00000044112-D1
Bos grunniens
ENSBTAP00000044112-D1
I
0.914
Brh_R005605
Buceros rhinoceros
Brh_R005605
I
0.914
Afo_R014913
Aptenodytes forsteri
Afo_R014913
I
0.914
Alligator_sinensis_CCG001917.1
Alligator sinensis
Alligator_sinensis_CCG001917.1
I
0.914
ENSP00000356857
Macaca fascicularis
ENSP00000356857
I
0.914
Gfo_R006439
Geospiza fortis
Gfo_R006439
I
0.914
tcf21.L
Xenopus laevis
XB-GENE-484809
I
0.914
msc
Xenopus tropicalis
XB-GENE-978233
I
0.914
tcf21
Xenopus tropicalis
XB-GENE-484805
I
0.914
Ogr02938
Ophisaurus gracilis
Ogr02938
I
0.914
Myotis_brandtii_TCF21_10035690
Myotis brandtii
Myotis_brandtii_TCF21_10035690
I
0.914
Aan_R009769
Calypte anna
Aan_R009769
I
0.914
ENSXMAG00000004322
Xiphophorus maculatus
ENSXMAG00000004322
I
0.914
MSC
Tupaia belangeri
ENSTBEG00000014659
I
0.914
MSC
Taeniopygia guttata
ENSTGUG00000011502
I
0.914
ENSSTOG00000024832
Ictidomys tridecemlineatus
ENSSTOG00000024832
I
0.914
ENSSTOG00000023733
Ictidomys tridecemlineatus
ENSSTOG00000023733
I
0.914
ENSSSCG00000004174
Sus scrofa
ENSSSCG00000004174
I
0.914
MSC
Sus scrofa
ENSSSCG00000006187
I
0.914
TCF21
Taeniopygia guttata
ENSTGUG00000011548
I
0.914
tcf21
Tetraodon nigroviridis
ENSTNIG00000016326
I
0.914
MSC
Vicugna pacos
ENSVPAG00000000378
I
0.914
TCF21
Vicugna pacos
ENSVPAG00000006271
I
0.914
MSC
Tursiops truncatus
ENSTTRG00000017260
I
0.914
TCF21
Tursiops truncatus
ENSTTRG00000009645
I
0.914
tcf21
Takifugu rubripes
ENSTRUG00000003919
I
0.914
TCF21
Monodelphis domestica
ENSMODG00000017516
I
0.914
Msc
Rattus norvegicus
ENSRNOG00000007540
I
0.914
tcf21
Danio rerio
ENSDARG00000036869
I
0.914
MSC
Dasypus novemcinctus
ENSDNOG00000019019
I
0.914
ENSCSAG00000016705
Chlorocebus sabaeus
ENSCSAG00000016705
I
0.914
ENSCSAG00000013709
Chlorocebus sabaeus
ENSCSAG00000013709
I
0.914
TCF21
Cavia porcellus
ENSCPOG00000024201
I
0.914
TCF21
Dasypus novemcinctus
ENSDNOG00000042846
I
0.914
MSC
Equus caballus
ENSECAG00000008333
I
0.914
ENSFALG00000011861
Ficedula albicollis
ENSFALG00000011861
I
0.914
ENSFALG00000008455
Ficedula albicollis
ENSFALG00000008455
I
0.914
TCF21
Echinops telfairi
ENSETEG00000012492
I
0.914
MSC
Erinaceus europaeus
ENSEEUG00000005021
I
0.914
ENSCPOG00000004726
Cavia porcellus
ENSCPOG00000004726
I
0.914
MSC
Callithrix jacchus
ENSCJAG00000007766
I
0.914
MSC
Anolis carolinensis
ENSACAG00000014585
I
0.914
TCF21
Anolis carolinensis
ENSACAG00000010325
I
0.914
ENSAMEG00000005942
Ailuropoda melanoleuca
ENSAMEG00000005942
I
0.914
MSC
Monodelphis domestica
ENSMODG00000007225
I
0.914
ENSAMEG00000015953
Ailuropoda melanoleuca
ENSAMEG00000015953
I
0.914
ENSAPLG00000008024
Anas platyrhynchos
ENSAPLG00000008024
I
0.914
MSC
Bos taurus
ENSBTAG00000005404
I
0.914
TCF21
Callithrix jacchus
ENSCJAG00000002811
I
0.914
MSC
Canis familiaris
ENSCAFG00000007923
I
0.914
TCF21
Canis familiaris
ENSCAFG00000000205
I
0.914
TCF21
Bos taurus
ENSBTAG00000021827
I
0.914
TCF21
Felis catus
ENSFCAG00000031261
I
0.914
TCF21
Equus caballus
ENSECAG00000019197
I
0.914
ENSLOCG00000016232
Lepisosteus oculatus
ENSLOCG00000016232
I
0.914
ENSMEUG00000005491
Macropus eugenii
ENSMEUG00000005491
I
0.914
ENSLOCG00000003912
Lepisosteus oculatus
ENSLOCG00000003912
I
0.914
TCF21
Loxodonta africana
ENSLAFG00000009507
I
0.914
TCF21
Homo sapiens
ENSG00000118526
D
0.914
TCF21
Meleagris gallopavo
ENSMGAG00000013117
I
0.914
ENSMICG00000014144
Microcebus murinus
ENSMICG00000014144
I
0.914
TCF21
Macaca mulatta
ENSMMUG00000002871
I
0.914
MSC
Macaca mulatta
ENSMMUG00000000947
I
0.914
TCF21
Myotis lucifugus
ENSMLUG00000009194
I
0.914
MSC
Myotis lucifugus
ENSMLUG00000008572
I
0.914
ENSLACG00000005024
Latimeria chalumnae
ENSLACG00000005024
I
0.914
MSC
Loxodonta africana
ENSLAFG00000002649
I
0.914
TCF21
Gorilla gorilla
ENSGGOG00000005460
I
0.914
TCF21
Gallus gallus
ENSGALG00000029024
I
0.914
MSC
Gorilla gorilla
ENSGGOG00000009955
I
0.914
ENSGALG00000019470
Gallus gallus
ENSGALG00000019470
I
0.914
ENSLACG00000014348
Latimeria chalumnae
ENSLACG00000014348
I
0.894
SPU_012008
Strongylocentrotus purpuratus
SPU_012008
I
0.890
BGLB011346
Biomphalaria glabrata
BGLB011346
I
0.890
ENSPFOG00000020725
Poecilia formosa
ENSPFOG00000020725
I
0.886
CapteG80741
Capitella teleta
CapteG80741
I
0.886
CGI_10026944
Crassostrea gigas
CGI_10026944
I
0.886
msc
Gasterosteus aculeatus
ENSGACG00000002802
I
0.886
Cflo_04912--XP_001121050.1_APIME
Camponotus floridanus
Cflo_04912--XP_001121050.1_APIME
I
0.886
tcf21
Gasterosteus aculeatus
ENSGACG00000010957
I
0.886
ENSXMAG00000010332
Xiphophorus maculatus
ENSXMAG00000010332
I
0.886
ENSPMAG00000000379
Petromyzon marinus
ENSPMAG00000000379
I
0.886
msc
Danio rerio
ENSDARG00000045353
I
0.886
msc
Tetraodon nigroviridis
ENSTNIG00000008188
I
0.886
ENSGMOG00000019481
Gadus morhua
ENSGMOG00000019481
I
0.886
msc
Takifugu rubripes
ENSTRUG00000012425
I
0.886
msc
Oryzias latipes
ENSORLG00000008030
I
0.886
ENSONIG00000014278
Oreochromis niloticus
ENSONIG00000014278
I
0.886
RPRC001590
Rhodnius prolixus
RPRC001590
I
0.883
HHAL000695-PA
Halyomorpha halys
HHAL000695-PA
I
0.883
ENSAMXG00000000487
Astyanax mexicanus
ENSAMXG00000000487
I
0.883
LDEC005027
Leptinotarsa decemlineata
LDEC005027
I
0.875
BGIBMGA012033
Bombyx mori
BGIBMGA012033
I
0.875
Hsal_01862--XP_001122645.1_APIME
Harpegnathos saltator
Hsal_01862--XP_001122645.1_APIME
I
0.875
SMAR006929
Strigamia maritima
SMAR006929
I
0.875
L798_06836
Zootermopsis nevadensis
L798_06836
I
0.875
GB42177
Apis mellifera
GB42177
I
0.875
KGM_20305
Danaus plexippus
KGM_20305
I
0.875
TC002349
Tribolium castaneum
TC002349
I
0.875
ENSAMXG00000004351
Astyanax mexicanus
ENSAMXG00000004351
I
0.875
fgenesh2_pg.scaffold_201000026
Branchiostoma floridae
fgenesh2_pg.scaffold_201000026
I
0.871
fgenesh2_pg.scaffold_201000027
Branchiostoma floridae
fgenesh2_pg.scaffold_201000027
I
0.871
HelroG188977
Helobdella robusta
HelroG188977
I
0.870
fgenesh2_pg.scaffold_201000029
Branchiostoma floridae
fgenesh2_pg.scaffold_201000029
I
0.867
gw.912.11.1
Branchiostoma floridae
gw.912.11.1
I
0.862
fgenesh2_pg.scaffold_201000028
Branchiostoma floridae
fgenesh2_pg.scaffold_201000028
I
0.862
LotgiG99224
Lottia gigantea
LotgiG99224
I
0.862
LLOJ001927
Lutzomyia longipalpis
LLOJ001927
I
0.859
PPAI008462
Phlebotomus papatasi
PPAI008462
I
0.859
CLEC012607
Cimex lectularius
CLEC012607
I
0.855
Smp_022610
Schistosoma mansoni
Smp_022610
I
0.855
A_02746
Schistosoma haematobium
A_02746
I
0.855
Sjc_0073180
Schistosoma japonicum
Sjc_0073180
I
0.855
T265_00953
Opisthorchis viverrini
T265_00953
I
0.855
TRE_0000636201
Trichobilharzia regenti
TRE_0000636201
I
0.855
D915_08809
Fasciola hepatica
D915_08809
I
0.855
SMTD_0000660301
Schistosoma mattheei
SMTD_0000660301
I
0.855
SCUD_0001558401
Schistosoma curassoni
SCUD_0001558401
I
0.855
csin111822
Clonorchis sinensis
csin111822
I
0.855
SMRZ_0001749101
Schistosoma margrebowiei
SMRZ_0001749101
I
0.855
DAPPUDRAFT_37461
Daphnia pulex
DAPPUDRAFT_37461
I
0.855
ISCW019706
Ixodes scapularis
ISCW019706
I
0.851
Sakowv30031408m.g
Saccoglossus kowalevskii
Sakowv30031408m.g
I
0.851
ACYPI002601
Acyrthosiphon pisum
ACYPI002601
I
0.851
AMEC000644
Anopheles melas
AMEC000644
I
0.849
AMAM016192
Anopheles maculatus
AMAM016192
I
0.849
AMEM011707
Anopheles merus
AMEM011707
I
0.849
AFUN008043
Anopheles funestus
AFUN008043
I
0.849
AMIN011264
Anopheles minimus
AMIN011264
I
0.849
ASTEI06898
Anopheles stephensi
ASTEI06898
I
0.849
AQUA002051
Anopheles quadriannulatus
AQUA002051
I
0.849
AEPI000467
Anopheles epiroticus
AEPI000467
I
0.849
AALB007822
Anopheles albimanus
AALB007822
I
0.849
CPIJ016930
Culex quinquefasciatus
CPIJ016930
I
0.849
CpipJ_CPIJ016930
Culex pipiens
CpipJ_CPIJ016930
I
0.849
ADIR008037
Anopheles dirus
ADIR008037
I
0.849
AGAP007124
Anopheles gambiae
AGAP007124
I
0.849
AALB007560
Anopheles albimanus
AALB007560
I
0.849
AAEL010031
Aedes aegypti
AAEL010031
I
0.849
AARA007787
Anopheles arabiensis
AARA007787
I
0.849
ACUA017871
Anopheles culicifacies
ACUA017871
I
0.849
ACHR000018
Anopheles christyi
ACHR000018
I
0.849
ACOM025280
Anopheles coluzzii
ACOM025280
I
0.849
AATE012411
Anopheles atroparvus
AATE012411
I
0.849
MCOS_0000023201
Mesocestoides corti
MCOS_0000023201
I
0.842
EmuJ_000624300
Echinococcus multilocularis
EmuJ_000624300
I
0.842
ECANG7_04949
Echinococcus canadensis
ECANG7_04949
I
0.842
TASK_0000025401
Taenia asiatica
TASK_0000025401
I
0.842
TsM_000945000
Taenia solium
TsM_000945000
I
0.842
PHUM294350
Pediculus humanus
PHUM294350
I
0.840
ACEP13483
Atta cephalotes
ACEP13483
I
0.840
SINV12414
Solenopsis invicta
SINV12414
I
0.840
Pvit_15024
Pogona vitticeps
Pvit_15024
I
0.724
ENSPSIG00000018135
Pelodiscus sinensis
ENSPSIG00000018135
I
0.724
Myotis_brandtii_MSC_10031663
Myotis brandtii
Myotis_brandtii_MSC_10031663
I
0.724
Alligator_sinensis_CCG018129.1
Alligator sinensis
Alligator_sinensis_CCG018129.1
I
0.724