MSC (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000178860 T034325_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MSC
M02801_2.00
Homo sapiens
AACAGCTGTT

AACAGCTGTT
SELEX
Jolma et al.(2013)
MSC_1
(Direct) (Direct)
MSC
M04183_2.00
Homo sapiens
NRMCAGMTGBYN

NRVCAKCTGKYN
SELEX
Yin et al.(2017)
MSC_eDBD_HT-SELEX_1
(Direct) (Direct)
MSC
M04184_2.00
Homo sapiens
NRVCAYVTGBYN

NRVCABRTGBYN
SELEX
Yin et al.(2017)
MSC_eDBD_HT-SELEX_2
(Direct) (Direct)
MSC
M04185_2.00
Homo sapiens
NRVCAGCTGBBN

NVVCAGCTGBYN
SELEX
Yin et al.(2017)
MSC_eDBD_Methyl-HT-SELEX_1
(Direct) (Direct)
MSC
M04186_2.00
Homo sapiens
BRMCATATGKYV

BRMCATATGKYV
SELEX
Yin et al.(2017)
MSC_eDBD_Methyl-HT-SELEX_2
(Direct) (Direct)
MSC
M04187_2.00
Homo sapiens
NRMCAGCTGBYV

BRVCAGCTGKYN
SELEX
Yin et al.(2017)
MSC_FL_HT-SELEX_1
(Direct) (Direct)
MSC
M04188_2.00
Homo sapiens
BRMCATATGKYN

NRMCATATGKYV
SELEX
Yin et al.(2017)
MSC_FL_HT-SELEX_2
(Direct) (Direct)
MSC
M04189_2.00
Homo sapiens
BRACAGCTGTYV

BRACAGCTGTYV
SELEX
Yin et al.(2017)
MSC_FL_Methyl-HT-SELEX_1
(Direct) (Direct)
MSC
M04190_2.00
Homo sapiens
BRMCATATGKYV

BRMCATATGKYV
SELEX
Yin et al.(2017)
MSC_FL_Methyl-HT-SELEX_2
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Msc
M01730_2.00
Mus musculus
NVCRKMYGBN

NVCRKMYGBN
PBM
Weirauch et al.(2014)
pTH5112
0.914 1.000
Tcf21
M01746_2.00
Mus musculus
RMCAKMTGK

MCAKMTGKY
PBM
Weirauch et al.(2014)
pTH5087
0.914 0.981
Tcf21
M02819_2.00
Mus musculus
VNAACAGCTGTTVN

NBAACAGCTGTTNB
SELEX
Jolma et al.(2013)
Tcf21_1
0.914 0.981
TCF21
M04092_2.00
Homo sapiens
BAACAGCTGBYN

NRVCAGCTGTTV
SELEX
Yin et al.(2017)
TCF21_eDBD_HT-SELEX_1
0.914 0.981
TCF21
M04093_2.00
Homo sapiens
NRCCATATGKYV

BRMCATATGGYN
SELEX
Yin et al.(2017)
TCF21_eDBD_HT-SELEX_2
0.914 0.981
TCF21
M04094_2.00
Homo sapiens
BAACAGCTGTYV

BRACAGCTGTTV
SELEX
Yin et al.(2017)
TCF21_eDBD_Methyl-HT-SELEX_1
0.914 0.981
TCF21
M04095_2.00
Homo sapiens
BACCATATGKYV

BRMCATATGGTV
SELEX
Yin et al.(2017)
TCF21_eDBD_Methyl-HT-SELEX_2
0.914 0.981
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000321445 bHLH 108 160

Links

Other bHLH family TFs
Other Homo sapiens TFs

188 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action