MSC (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000178860 T034325_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MSC
M02801_2.00
Homo sapiens
AACAGCTGTT

AACAGCTGTT
SELEX
Jolma et al.(2013)
MSC_1
(Direct) (Direct)
MSC
M04183_2.00
Homo sapiens
NRMCAGMTGBYN

NRVCAKCTGKYN
SELEX
Yin et al.(2017)
MSC_eDBD_HT-SELEX_1
(Direct) (Direct)
MSC
M04184_2.00
Homo sapiens
NRVCAYVTGBYN

NRVCABRTGBYN
SELEX
Yin et al.(2017)
MSC_eDBD_HT-SELEX_2
(Direct) (Direct)
MSC
M04185_2.00
Homo sapiens
NRVCAGCTGBBN

NVVCAGCTGBYN
SELEX
Yin et al.(2017)
MSC_eDBD_Methyl-HT-SELEX_1
(Direct) (Direct)
MSC
M04186_2.00
Homo sapiens
BRMCATATGKYV

BRMCATATGKYV
SELEX
Yin et al.(2017)
MSC_eDBD_Methyl-HT-SELEX_2
(Direct) (Direct)
MSC
M04187_2.00
Homo sapiens
NRMCAGCTGBYV

BRVCAGCTGKYN
SELEX
Yin et al.(2017)
MSC_FL_HT-SELEX_1
(Direct) (Direct)
MSC
M04188_2.00
Homo sapiens
BRMCATATGKYN

NRMCATATGKYV
SELEX
Yin et al.(2017)
MSC_FL_HT-SELEX_2
(Direct) (Direct)
MSC
M04189_2.00
Homo sapiens
BRACAGCTGTYV

BRACAGCTGTYV
SELEX
Yin et al.(2017)
MSC_FL_Methyl-HT-SELEX_1
(Direct) (Direct)
MSC
M04190_2.00
Homo sapiens
BRMCATATGKYV

BRMCATATGKYV
SELEX
Yin et al.(2017)
MSC_FL_Methyl-HT-SELEX_2
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Msc
M01730_2.00
Mus musculus
NVCRKMYGBN

NVCRKMYGBN
PBM
Weirauch et al.(2014)
pTH5112
0.914 1.000
Tcf21
M01746_2.00
Mus musculus
RMCAKMTGK

MCAKMTGKY
PBM
Weirauch et al.(2014)
pTH5087
0.914 0.981
Tcf21
M02819_2.00
Mus musculus
VNAACAGCTGTTVN

NBAACAGCTGTTNB
SELEX
Jolma et al.(2013)
Tcf21_1
0.914 0.981
TCF21
M04092_2.00
Homo sapiens
BAACAGCTGBYN

NRVCAGCTGTTV
SELEX
Yin et al.(2017)
TCF21_eDBD_HT-SELEX_1
0.914 0.981
TCF21
M04093_2.00
Homo sapiens
NRCCATATGKYV

BRMCATATGGYN
SELEX
Yin et al.(2017)
TCF21_eDBD_HT-SELEX_2
0.914 0.981
TCF21
M04094_2.00
Homo sapiens
BAACAGCTGTYV

BRACAGCTGTTV
SELEX
Yin et al.(2017)
TCF21_eDBD_Methyl-HT-SELEX_1
0.914 0.981
TCF21
M04095_2.00
Homo sapiens
BACCATATGKYV

BRMCATATGGTV
SELEX
Yin et al.(2017)
TCF21_eDBD_Methyl-HT-SELEX_2
0.914 0.981
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000321445 bHLH 108 160

Links

Other bHLH family TFs
Other Homo sapiens TFs

188 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
AAEL010031 Aedes aegypti AAEL010031 I 0.849
AALB007560 Anopheles albimanus AALB007560 I 0.849
AALB007822 Anopheles albimanus AALB007822 I 0.849
Aan_R009769 Calypte anna Aan_R009769 I 0.914
AARA007787 Anopheles arabiensis AARA007787 I 0.849
AATE012411 Anopheles atroparvus AATE012411 I 0.849
ACEP13483 Atta cephalotes ACEP13483 I 0.840
ACHR000018 Anopheles christyi ACHR000018 I 0.849
ACOM025280 Anopheles coluzzii ACOM025280 I 0.849
ACUA017871 Anopheles culicifacies ACUA017871 I 0.849
ACYPI002601 Acyrthosiphon pisum ACYPI002601 I 0.851
ADIR008037 Anopheles dirus ADIR008037 I 0.849
AEPI000467 Anopheles epiroticus AEPI000467 I 0.849
Afo_R014913 Aptenodytes forsteri Afo_R014913 I 0.914
AFUN008043 Anopheles funestus AFUN008043 I 0.849
AGAP007124 Anopheles gambiae AGAP007124 I 0.849
Alligator_sinensis_CCG001917.1 Alligator sinensis Alligator_sinensis_CCG001917.1 I 0.914
Alligator_sinensis_CCG018129.1 Alligator sinensis Alligator_sinensis_CCG018129.1 I 0.724
AMAM016192 Anopheles maculatus AMAM016192 I 0.849
AMEC000644 Anopheles melas AMEC000644 I 0.849
AMEM011707 Anopheles merus AMEM011707 I 0.849
AMIN011264 Anopheles minimus AMIN011264 I 0.849
AQUA002051 Anopheles quadriannulatus AQUA002051 I 0.849
ASTEI06898 Anopheles stephensi ASTEI06898 I 0.849
A_02746 Schistosoma haematobium A_02746 I 0.855
BGIBMGA012033 Bombyx mori BGIBMGA012033 I 0.875
BGLB011346 Biomphalaria glabrata BGLB011346 I 0.890
Brh_R005605 Buceros rhinoceros Brh_R005605 I 0.914
CapteG80741 Capitella teleta CapteG80741 I 0.886
Cflo_04912--XP_001121050.1_APIME Camponotus floridanus Cflo_04912--XP_001121050.1_APIME I 0.886
CGI_10026944 Crassostrea gigas CGI_10026944 I 0.886
CLEC012607 Cimex lectularius CLEC012607 I 0.855
CPIJ016930 Culex quinquefasciatus CPIJ016930 I 0.849
CpipJ_CPIJ016930 Culex pipiens CpipJ_CPIJ016930 I 0.849
csin111822 Clonorchis sinensis csin111822 I 0.855
D915_08809 Fasciola hepatica D915_08809 I 0.855
DAPPUDRAFT_37461 Daphnia pulex DAPPUDRAFT_37461 I 0.855
ECANG7_04949 Echinococcus canadensis ECANG7_04949 I 0.842
EmuJ_000624300 Echinococcus multilocularis EmuJ_000624300 I 0.842
ENSAMEG00000005942 Ailuropoda melanoleuca ENSAMEG00000005942 I 0.914
ENSAMEG00000015953 Ailuropoda melanoleuca ENSAMEG00000015953 I 0.914
ENSAMXG00000000487 Astyanax mexicanus ENSAMXG00000000487 I 0.883
ENSAMXG00000004351 Astyanax mexicanus ENSAMXG00000004351 I 0.875
ENSAPLG00000008024 Anas platyrhynchos ENSAPLG00000008024 I 0.914
ENSBTAP00000044112-D1 Bos grunniens ENSBTAP00000044112-D1 I 0.914
ENSBTAP00000052463-D1 Bos grunniens ENSBTAP00000052463-D1 I 0.914
ENSCPOG00000004726 Cavia porcellus ENSCPOG00000004726 I 0.914
ENSCSAG00000013709 Chlorocebus sabaeus ENSCSAG00000013709 I 0.914
ENSCSAG00000016705 Chlorocebus sabaeus ENSCSAG00000016705 I 0.914
ENSFALG00000008455 Ficedula albicollis ENSFALG00000008455 I 0.914
ENSFALG00000011861 Ficedula albicollis ENSFALG00000011861 I 0.914
ENSGALG00000019470 Gallus gallus ENSGALG00000019470 I 0.914
ENSGMOG00000019481 Gadus morhua ENSGMOG00000019481 I 0.886
ENSLACG00000005024 Latimeria chalumnae ENSLACG00000005024 I 0.914
ENSLACG00000014348 Latimeria chalumnae ENSLACG00000014348 I 0.894
ENSLOCG00000003912 Lepisosteus oculatus ENSLOCG00000003912 I 0.914
ENSLOCG00000016232 Lepisosteus oculatus ENSLOCG00000016232 I 0.914
ENSMEUG00000005491 Macropus eugenii ENSMEUG00000005491 I 0.914
ENSMICG00000014144 Microcebus murinus ENSMICG00000014144 I 0.914
ENSMPUG00000010593 Mustela putorius furo ENSMPUG00000010593 I 0.914
ENSMPUG00000014798 Mustela putorius furo ENSMPUG00000014798 I 0.914
ENSNLEG00000011452 Nomascus leucogenys ENSNLEG00000011452 I 0.914
ENSNLEG00000014647 Nomascus leucogenys ENSNLEG00000014647 I 0.914
ENSOARG00000004844 Ovis aries ENSOARG00000004844 I 0.914
ENSOARG00000014623 Ovis aries ENSOARG00000014623 I 0.914
ENSONIG00000000446 Oreochromis niloticus ENSONIG00000000446 I 0.914
ENSONIG00000014278 Oreochromis niloticus ENSONIG00000014278 I 0.886
ENSP00000321445 Macaca fascicularis ENSP00000321445 I 0.914
ENSP00000356857 Macaca fascicularis ENSP00000356857 I 0.914
ENSPANG00000022301 Papio anubis ENSPANG00000022301 I 0.914
ENSPANG00000024238 Papio anubis ENSPANG00000024238 I 0.914
ENSPCAG00000006459 Procavia capensis ENSPCAG00000006459 I 0.914
ENSPFOG00000010821 Poecilia formosa ENSPFOG00000010821 I 0.914
ENSPFOG00000020725 Poecilia formosa ENSPFOG00000020725 I 0.886
ENSPMAG00000000379 Petromyzon marinus ENSPMAG00000000379 I 0.886
ENSPPYG00000017022 Pongo abelii ENSPPYG00000017022 I 0.914
ENSPPYG00000018665 Pongo abelii ENSPPYG00000018665 I 0.914
ENSPSIG00000003604 Pelodiscus sinensis ENSPSIG00000003604 I 0.914
ENSPSIG00000018135 Pelodiscus sinensis ENSPSIG00000018135 I 0.724
ENSSHAG00000002801 Sarcophilus harrisii ENSSHAG00000002801 I 0.914
ENSSHAG00000004870 Sarcophilus harrisii ENSSHAG00000004870 I 0.914
ENSSSCG00000004174 Sus scrofa ENSSSCG00000004174 I 0.914
ENSSTOG00000023733 Ictidomys tridecemlineatus ENSSTOG00000023733 I 0.914
ENSSTOG00000024832 Ictidomys tridecemlineatus ENSSTOG00000024832 I 0.914
ENSXMAG00000004322 Xiphophorus maculatus ENSXMAG00000004322 I 0.914
ENSXMAG00000010332 Xiphophorus maculatus ENSXMAG00000010332 I 0.886
fgenesh2_pg.scaffold_201000026 Branchiostoma floridae fgenesh2_pg.scaffold_201000026 I 0.871
fgenesh2_pg.scaffold_201000027 Branchiostoma floridae fgenesh2_pg.scaffold_201000027 I 0.871
fgenesh2_pg.scaffold_201000028 Branchiostoma floridae fgenesh2_pg.scaffold_201000028 I 0.862
fgenesh2_pg.scaffold_201000029 Branchiostoma floridae fgenesh2_pg.scaffold_201000029 I 0.867
GB42177 Apis mellifera GB42177 I 0.875
Gfo_R006439 Geospiza fortis Gfo_R006439 I 0.914
gw.912.11.1 Branchiostoma floridae gw.912.11.1 I 0.862
HelroG188977 Helobdella robusta HelroG188977 I 0.870
HHAL000695-PA Halyomorpha halys HHAL000695-PA I 0.883
Hsal_01862--XP_001122645.1_APIME Harpegnathos saltator Hsal_01862--XP_001122645.1_APIME I 0.875
ISCW019706 Ixodes scapularis ISCW019706 I 0.851
KGM_20305 Danaus plexippus KGM_20305 I 0.875
L798_06836 Zootermopsis nevadensis L798_06836 I 0.875
LDEC005027 Leptinotarsa decemlineata LDEC005027 I 0.875
LLOJ001927 Lutzomyia longipalpis LLOJ001927 I 0.859
LotgiG99224 Lottia gigantea LotgiG99224 I 0.862
MCOS_0000023201 Mesocestoides corti MCOS_0000023201 I 0.842
MSC Monodelphis domestica ENSMODG00000007225 I 0.914
MSC Erinaceus europaeus ENSEEUG00000005021 I 0.914
MSC Anolis carolinensis ENSACAG00000014585 I 0.914
MSC Bos taurus ENSBTAG00000005404 I 0.914
MSC Taeniopygia guttata ENSTGUG00000011502 I 0.914
MSC Myotis lucifugus ENSMLUG00000008572 I 0.914
MSC Dasypus novemcinctus ENSDNOG00000019019 I 0.914
msc Danio rerio ENSDARG00000045353 I 0.886
MSC Callithrix jacchus ENSCJAG00000007766 I 0.914
MSC Canis familiaris ENSCAFG00000007923 I 0.914
MSC Vicugna pacos ENSVPAG00000000378 I 0.914
MSC Pteropus vampyrus ENSPVAG00000009083 I 0.914
MSC Pan troglodytes ENSPTRG00000020339 I 0.914
msc Xenopus tropicalis XB-GENE-978233 I 0.914
MSC Oryctolagus cuniculus ENSOCUG00000007208 I 0.914
MSC Otolemur garnettii ENSOGAG00000013827 I 0.914
MSC Gorilla gorilla ENSGGOG00000009955 I 0.914
MSC Macaca mulatta ENSMMUG00000000947 I 0.914
msc Oryzias latipes ENSORLG00000008030 I 0.886
msc Gasterosteus aculeatus ENSGACG00000002802 I 0.886
Msc Rattus norvegicus ENSRNOG00000007540 I 0.914
MSC Loxodonta africana ENSLAFG00000002649 I 0.914
MSC Tursiops truncatus ENSTTRG00000017260 I 0.914
MSC Procavia capensis ENSPCAG00000004330 I 0.914
msc Takifugu rubripes ENSTRUG00000012425 I 0.886
msc Tetraodon nigroviridis ENSTNIG00000008188 I 0.886
MSC Equus caballus ENSECAG00000008333 I 0.914
MSC Tupaia belangeri ENSTBEG00000014659 I 0.914
MSC Sus scrofa ENSSSCG00000006187 I 0.914
Msc Mus musculus ENSMUSG00000025930 D 0.914
Myotis_brandtii_MSC_10031663 Myotis brandtii Myotis_brandtii_MSC_10031663 I 0.724
Myotis_brandtii_TCF21_10035690 Myotis brandtii Myotis_brandtii_TCF21_10035690 I 0.914
Ogr02938 Ophisaurus gracilis Ogr02938 I 0.914
PHUM294350 Pediculus humanus PHUM294350 I 0.840
PPAI008462 Phlebotomus papatasi PPAI008462 I 0.859
Pvit_15024 Pogona vitticeps Pvit_15024 I 0.724
RPRC001590 Rhodnius prolixus RPRC001590 I 0.883
Sakowv30031408m.g Saccoglossus kowalevskii Sakowv30031408m.g I 0.851
SCUD_0001558401 Schistosoma curassoni SCUD_0001558401 I 0.855
SINV12414 Solenopsis invicta SINV12414 I 0.840
Sjc_0073180 Schistosoma japonicum Sjc_0073180 I 0.855
SMAR006929 Strigamia maritima SMAR006929 I 0.875
Smp_022610 Schistosoma mansoni Smp_022610 I 0.855
SMRZ_0001749101 Schistosoma margrebowiei SMRZ_0001749101 I 0.855
SMTD_0000660301 Schistosoma mattheei SMTD_0000660301 I 0.855
SPU_012008 Strongylocentrotus purpuratus SPU_012008 I 0.890
T265_00953 Opisthorchis viverrini T265_00953 I 0.855
TASK_0000025401 Taenia asiatica TASK_0000025401 I 0.842
TC002349 Tribolium castaneum TC002349 I 0.875
TCF21 Homo sapiens ENSG00000118526 D 0.914
tcf21 Gasterosteus aculeatus ENSGACG00000010957 I 0.886
TCF21 Felis catus ENSFCAG00000031261 I 0.914
TCF21 Echinops telfairi ENSETEG00000012492 I 0.914
TCF21 Equus caballus ENSECAG00000019197 I 0.914
TCF21 Gallus gallus ENSGALG00000029024 I 0.914
TCF21 Dasypus novemcinctus ENSDNOG00000042846 I 0.914
TCF21 Cavia porcellus ENSCPOG00000024201 I 0.914
TCF21 Callithrix jacchus ENSCJAG00000002811 I 0.914
TCF21 Canis familiaris ENSCAFG00000000205 I 0.914
TCF21 Bos taurus ENSBTAG00000021827 I 0.914
TCF21 Anolis carolinensis ENSACAG00000010325 I 0.914
tcf21 Danio rerio ENSDARG00000036869 I 0.914
TCF21 Gorilla gorilla ENSGGOG00000005460 I 0.914
TCF21 Loxodonta africana ENSLAFG00000009507 I 0.914
TCF21 Tursiops truncatus ENSTTRG00000009645 I 0.914
tcf21 Takifugu rubripes ENSTRUG00000003919 I 0.914
tcf21 Tetraodon nigroviridis ENSTNIG00000016326 I 0.914
TCF21 Taeniopygia guttata ENSTGUG00000011548 I 0.914
TCF21 Pteropus vampyrus ENSPVAG00000009085 I 0.914
tcf21 Xenopus tropicalis XB-GENE-484805 I 0.914
TCF21 Oryctolagus cuniculus ENSOCUG00000017761 I 0.914
TCF21 Pan troglodytes ENSPTRG00000018622 I 0.914
tcf21 Oryzias latipes ENSORLG00000016491 I 0.914
TCF21 Otolemur garnettii ENSOGAG00000034073 I 0.914
TCF21 Ornithorhynchus anatinus ENSOANG00000013098 I 0.914
Tcf21 Mus musculus ENSMUSG00000045680 D 0.914
TCF21 Monodelphis domestica ENSMODG00000017516 I 0.914
TCF21 Macaca mulatta ENSMMUG00000002871 I 0.914
TCF21 Myotis lucifugus ENSMLUG00000009194 I 0.914
TCF21 Meleagris gallopavo ENSMGAG00000013117 I 0.914
Tcf21 Rattus norvegicus ENSRNOG00000016700 I 0.914
TCF21 Vicugna pacos ENSVPAG00000006271 I 0.914
tcf21.L Xenopus laevis XB-GENE-484809 I 0.914
TRE_0000636201 Trichobilharzia regenti TRE_0000636201 I 0.855
TsM_000945000 Taenia solium TsM_000945000 I 0.842