CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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HES7
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000179111
T034326_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the hairy and enhancer of split family of bHLH transcription factors. The mouse ortholog of this gene is regulated by Notch signaling. The protein functions as a transcriptional repressor, and is implicated in correct patterning of the axial skeleton. A mutation in this gene has been shown to result in spondylocostal dysostosis. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
HES7
M02802_2.00
Homo sapiens
YGGCACGTGCCR
YGGCACGTGCCR
SELEX
Jolma et al.(2013)
HES7_1
(Direct)
(Direct)
HES7
M04191_2.00
Homo sapiens
NVCRCGTGSC
GSCACGYGBN
SELEX
Yin et al.(2017)
HES7_eDBD_HT-SELEX
(Direct)
(Direct)
HES7
M04192_2.00
Homo sapiens
NVCRCRTGVV
BBCAYGYGBN
SELEX
Yin et al.(2017)
HES7_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hes7
M01727_2.00
Mus musculus
NVCACGHGNN
NNCDCGTGBN
PBM
Weirauch et al.(2014)
pTH5260
0.914
0.981
Hes7
M09887_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$HES7_02
0.914
0.981
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000314774
bHLH
14
69
KMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRER
ENSP00000446205
bHLH
14
69
KMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRER
ENSP00000462491
bHLH
6
61
EMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRER
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
27 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy