FIGLA (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000183733 T034331_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
FIGLA
M02805_2.00		 Homo sapiens
HMCACCTGKN
NMCAGGTGKD		 SELEX
Jolma et al.(2013)
FIGLA_1		 (Direct) (Direct)
FIGLA
M04205_2.00		 Homo sapiens
HMCACCTGB
VCAGGTGKD		 SELEX
Yin et al.(2017)
FIGLA_eDBD_HT-SELEX		 (Direct) (Direct)
FIGLA
M04206_2.00		 Homo sapiens
HMCACCTGK
MCAGGTGKD		 SELEX
Yin et al.(2017)
FIGLA_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Figla
M01737_2.00 		Mus musculus
NNCASSTGN
NCASSTGNN		 PBM
Weirauch et al.(2014)
pTH5105 		0.890 0.923
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000333097 bHLH 66 118

Links

Other bHLH family TFs
Other Homo sapiens TFs

27 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPANG00000010751 Papio anubis ENSPANG00000010751 I 0.914
FIGLA Oryctolagus cuniculus ENSOCUG00000017295 I 0.914
ENSNLEG00000010223 Nomascus leucogenys ENSNLEG00000010223 I 0.914
ENSAMEG00000015931 Ailuropoda melanoleuca ENSAMEG00000015931 I 0.914
ENSPPYG00000012320 Pongo abelii ENSPPYG00000012320 I 0.914
ENSPPYG00000012737 Pongo abelii ENSPPYG00000012737 I 0.914
FIGLA Tursiops truncatus ENSTTRG00000011308 I 0.914
FIGLA Pteropus vampyrus ENSPVAG00000013376 I 0.914
FIGLA Pan troglodytes ENSPTRG00000012033 I 0.914
FIGLA Macaca mulatta ENSMMUG00000020852 I 0.914
ENSMPUG00000007271 Mustela putorius furo ENSMPUG00000007271 I 0.914
ENSCSAG00000015178 Chlorocebus sabaeus ENSCSAG00000015178 I 0.914
ENSDNOG00000019277 Dasypus novemcinctus ENSDNOG00000019277 I 0.914
FIGLA Gorilla gorilla ENSGGOG00000003953 I 0.914
ENSSTOG00000007556 Ictidomys tridecemlineatus ENSSTOG00000007556 I 0.903
FIGLA Sus scrofa ENSSSCG00000008321 I 0.903
Figla Dipodomys ordii ENSDORG00000000358 I 0.894
FIGLA Loxodonta africana ENSLAFG00000010827 I 0.894
Figla Mus musculus ENSMUSG00000030001 D 0.890
Figla Rattus norvegicus ENSRNOG00000015877 I 0.890
FIGLA Otolemur garnettii ENSOGAG00000030530 I 0.890
FIGLA Myotis lucifugus ENSMLUG00000017374 I 0.890
FIGLA Bos taurus ENSBTAG00000008905 I 0.882
FIGLA Equus caballus ENSECAG00000024203 I 0.879
FIGLA Echinops telfairi ENSETEG00000011908 I 0.870
ENSCJAG00000019358 Callithrix jacchus ENSCJAG00000019358 I 0.861
FIGLA Cavia porcellus ENSCPOG00000027561 I 0.860