HES4 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000188290 T034339_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hes1
M01726_2.00 		Mus musculus
NVCACGYKNN
NNMRCGTGBN		 PBM
Weirauch et al.(2014)
pTH5059 		0.890 0.889
HES1
M04090_2.00 		Homo sapiens
VVCACGYGHM
KDCRCGTGBB		 SELEX
Yin et al.(2017)
HES1_eDBD_HT-SELEX 		0.890 0.889
HES1
M09822_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HES1_Q2 		0.890 0.909
HES1
M09823_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HES1_Q3 		0.890 0.889
HES1
M09824_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HES1_Q4 		0.890 0.889
HES1
M09825_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HES1_Q6 		0.890 0.889
HES1
M04091_2.00 		Homo sapiens
VNYACNYNHN
NDNRNGTRNB		 SELEX
Yin et al.(2017)
HES1_eDBD_Methyl-HT-SELEX 		0.890 0.889
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000304595 bHLH 35 92
ENSP00000393198 bHLH 62 118
ENSP00000425085 bHLH 9 60

Links

Other bHLH family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

113 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action