OLIG2 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000205927 T034344_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
OLIG2
M02812_2.00
Homo sapiens
AMCATATGBY

RVCATATGKT
SELEX
Jolma et al.(2013)
OLIG2_1
(Direct) (Direct)
OLIG2
M02813_2.00
Homo sapiens
AMCATATGBY

RVCATATGKT
SELEX
Jolma et al.(2013)
OLIG2_2
(Direct) (Direct)
OLIG2
M04223_2.00
Homo sapiens
AACAKMTGTB

VACAKMTGTT
SELEX
Yin et al.(2017)
OLIG2_eDBD_HT-SELEX_1
(Direct) (Direct)
OLIG2
M04224_2.00
Homo sapiens
AMCATATGKY

RMCATATGKT
SELEX
Yin et al.(2017)
OLIG2_eDBD_HT-SELEX_2
(Direct) (Direct)
OLIG2
M04225_2.00
Homo sapiens
AACAKMTGKB

VMCAKMTGTT
SELEX
Yin et al.(2017)
OLIG2_eDBD_Methyl-HT-SELEX_1
(Direct) (Direct)
OLIG2
M04226_2.00
Homo sapiens
AMCATATGKT

AMCATATGKT
SELEX
Yin et al.(2017)
OLIG2_eDBD_Methyl-HT-SELEX_2
(Direct) (Direct)
OLIG2
M08742_2.00
Homo sapiens
NDNVHNRVVRVCAGMTGK

MCAKCTGBYBBYNDBNHN
Misc
Kulakovskiy et al.(2013)
OLIG2_HUMAN.H11MO.0.B
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Olig2
M08771_2.00
Mus musculus
NDNVHNRVVRVCAGMTGK

MCAKCTGBYBBYNDBNHN
Misc
Kulakovskiy et al.(2013)
OLIG2_MOUSE.H11MO.0.A
0.914 1.000
Olig2
M09477_2.00
Mus musculus
RVCAKMTGKH

DMCAKMTGBY
Misc
Heinz et al.(2010)
Neuron-Olig2_GSE30882
0.914 1.000
Olig3
M01745_2.00
Mus musculus
NWAHHATANNN

NNNTATDDTWN
PBM
Weirauch et al.(2014)
pTH5164
0.894 0.964
OLIG3
M02798_2.00
Homo sapiens
AMCATATGBY

RVCATATGKT
SELEX
Jolma et al.(2013)
OLIG3_1
0.894 0.964
OLIG3
M04175_2.00
Homo sapiens
RMCATATGSY

RSCATATGKY
SELEX
Yin et al.(2017)
OLIG3_FL_HT-SELEX
0.894 0.964
OLIG3
M04171_2.00
Homo sapiens
RMCATATGSY

RSCATATGKY
SELEX
Yin et al.(2017)
OLIG3_eDBD_HT-SELEX_1
0.894 0.964
OLIG3
M04172_2.00
Homo sapiens
AACAKMTGBT

AVCAKMTGTT
SELEX
Yin et al.(2017)
OLIG3_eDBD_HT-SELEX_2
0.894 0.964
OLIG3
M04176_2.00
Homo sapiens
RMCATATGGY

RCCATATGKY
SELEX
Yin et al.(2017)
OLIG3_FL_Methyl-HT-SELEX
0.894 0.964
OLIG3
M04173_2.00
Homo sapiens
RMCATATGSY

RSCATATGKY
SELEX
Yin et al.(2017)
OLIG3_eDBD_Methyl-HT-SELEX_1
0.894 0.964
OLIG3
M04174_2.00
Homo sapiens
VACAKMTGKY

RMCAKMTGTB
SELEX
Yin et al.(2017)
OLIG3_eDBD_Methyl-HT-SELEX_2
0.894 0.964
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000331040 bHLH 109 163
ENSP00000371794 bHLH 109 163

Links

Other bHLH family TFs
Other Homo sapiens TFs

111 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAMEG00000015013 Ailuropoda melanoleuca ENSAMEG00000015013 I 0.914
ENSAMEG00000019633 Ailuropoda melanoleuca ENSAMEG00000019633 I 0.894
Alligator_sinensis_CCG012594.1 Alligator sinensis Alligator_sinensis_CCG012594.1 I 0.894
ENSAPLG00000002295 Anas platyrhynchos ENSAPLG00000002295 I 0.894
Afo_R014889 Aptenodytes forsteri Afo_R014889 I 0.894
ENSAMXG00000026284 Astyanax mexicanus ENSAMXG00000026284 I 0.870
ENSAMXG00000026066 Astyanax mexicanus ENSAMXG00000026066 I 0.890
BGLB010755 Biomphalaria glabrata BGLB010755 I 0.847
ENSP00000356708-D1 Bos grunniens ENSP00000356708-D1 I 0.894
ENSBTAP00000021340-D1 Bos grunniens ENSBTAP00000021340-D1 I 0.914
OLIG3 Bos taurus ENSBTAG00000008749 I 0.894
Brh_R007937 Buceros rhinoceros Brh_R007937 I 0.894
OLIG2 Callithrix jacchus ENSCJAG00000009439 I 0.890
Aan_R009789 Calypte anna Aan_R009789 I 0.894
OLIG3 Canis familiaris ENSCAFG00000000265 I 0.894
OLIG2 Canis familiaris ENSCAFG00000028529 I 0.914
CapteG41307 Capitella teleta CapteG41307 I 0.858
CapteG65387 Capitella teleta CapteG65387 I 0.858
OLIG3 Cavia porcellus ENSCPOG00000007516 I 0.894
OLIG2 Cavia porcellus ENSCPOG00000011590 I 0.914
Cmyd_10005462 Chelonia mydas Cmyd_10005462 I 0.914
Cmyd_10011949 Chelonia mydas Cmyd_10011949 I 0.894
ENSCSAG00000018687 Chlorocebus sabaeus ENSCSAG00000018687 I 0.914
ENSCSAG00000000185 Chlorocebus sabaeus ENSCSAG00000000185 I 0.894
OLIG3 Choloepus hoffmanni ENSCHOG00000005165 I 0.894
CGI_10019998 Crassostrea gigas CGI_10019998 I 0.846
CGI_10023146 Crassostrea gigas CGI_10023146 I 0.847
olig2 Danio rerio ENSDARG00000040946 I 0.890
OLIG2 Dasypus novemcinctus ENSDNOG00000047420 I 0.914
OLIG3 Dasypus novemcinctus ENSDNOG00000042405 I 0.894
Olig3 Dipodomys ordii ENSDORG00000013033 I 0.894
ENSDORG00000006743 Dipodomys ordii ENSDORG00000006743 I 0.914
OLIG3 Echinops telfairi ENSETEG00000004562 I 0.894
ECPE_0001595001 Echinostoma caproni ECPE_0001595001 I 0.856
D915_09810 Fasciola hepatica D915_09810 I 0.856
OLIG3 Felis catus ENSFCAG00000030246 I 0.894
ENSFALG00000012862 Ficedula albicollis ENSFALG00000012862 I 0.894
ENSGMOG00000018006 Gadus morhua ENSGMOG00000018006 I 0.870
ENSGMOG00000018584 Gadus morhua ENSGMOG00000018584 I 0.870
ENSGALG00000027381 Gallus gallus ENSGALG00000027381 I 0.914
OLIG3 Gallus gallus ENSGALG00000013862 I 0.894
olig2 Gasterosteus aculeatus ENSGACG00000002152 I 0.870
OLIG3 Gasterosteus aculeatus ENSGACG00000010412 I 0.870
Gfo_R003786 Geospiza fortis Gfo_R003786 I 0.894
OLIG2 Gorilla gorilla ENSGGOG00000008780 I 0.914
OLIG3 Gorilla gorilla ENSGGOG00000001516 I 0.894
OLIG3 Homo sapiens ENSG00000177468 D 0.894
ENSSTOG00000020899 Ictidomys tridecemlineatus ENSSTOG00000020899 I 0.914
ENSSTOG00000020214 Ictidomys tridecemlineatus ENSSTOG00000020214 I 0.894
ENSLACG00000005481 Latimeria chalumnae ENSLACG00000005481 I 0.914
ENSLACG00000005047 Latimeria chalumnae ENSLACG00000005047 I 0.894
ENSLOCG00000017350 Lepisosteus oculatus ENSLOCG00000017350 I 0.894
ENSLOCG00000017506 Lepisosteus oculatus ENSLOCG00000017506 I 0.890
OLIG3 Loxodonta africana ENSLAFG00000005655 I 0.894
OLIG2 Loxodonta africana ENSLAFG00000028347 I 0.914
ENSP00000356708 Macaca fascicularis ENSP00000356708 I 0.894
OLIG2 Macaca mulatta ENSMMUG00000017652 I 0.914
ENSMMUG00000029441 Macaca mulatta ENSMMUG00000029441 I 0.894
ENSMEUG00000002914 Macropus eugenii ENSMEUG00000002914 I 0.914
ENSMICG00000004313 Microcebus murinus ENSMICG00000004313 I 0.914
OLIG3 Monodelphis domestica ENSMODG00000017418 I 0.894
OLIG2 Monodelphis domestica ENSMODG00000025338 I 0.914
ENSMPUG00000001227 Mustela putorius furo ENSMPUG00000001227 I 0.914
ENSMPUG00000018873 Mustela putorius furo ENSMPUG00000018873 I 0.894
Olig3 Mus musculus ENSMUSG00000045591 D 0.894
Olig2 Mus musculus ENSMUSG00000039830 D 0.914
Myotis_brandtii_OLIG3_10035715 Myotis brandtii Myotis_brandtii_OLIG3_10035715 I 0.894
OLIG3 Myotis lucifugus ENSMLUG00000026705 I 0.894
ENSNLEG00000019305 Nomascus leucogenys ENSNLEG00000019305 I 0.894
OLIG3 Ochotona princeps ENSOPRG00000003267 I 0.894
Ocbimv22001042m.g Octopus bimaculoides Ocbimv22001042m.g I 0.847
Ogr17936 Ophisaurus gracilis Ogr17936 I 0.914
ENSONIG00000017079 Oreochromis niloticus ENSONIG00000017079 I 0.870
ENSONIG00000020727 Oreochromis niloticus ENSONIG00000020727 I 0.894
OLIG3 Ornithorhynchus anatinus ENSOANG00000014796 I 0.894
OLIG3 Oryctolagus cuniculus ENSOCUG00000017289 I 0.894
olig2 Oryzias latipes ENSORLG00000010211 I 0.870
OLIG2 Otolemur garnettii ENSOGAG00000026818 I 0.914
OLIG3 Otolemur garnettii ENSOGAG00000011977 I 0.894
ENSOARG00000002572 Ovis aries ENSOARG00000002572 I 0.894
OLIG3 Pan troglodytes ENSPTRG00000018643 I 0.894
OLIG2 Pan troglodytes ENSPTRG00000013863 I 0.914
ENSPANG00000007664 Papio anubis ENSPANG00000007664 I 0.914
ENSPANG00000006465 Papio anubis ENSPANG00000006465 I 0.894
ENSPSIG00000001988 Pelodiscus sinensis ENSPSIG00000001988 I 0.914
ENSPSIG00000001778 Pelodiscus sinensis ENSPSIG00000001778 I 0.894
ENSPFOG00000004604 Poecilia formosa ENSPFOG00000004604 I 0.894
ENSPFOG00000015805 Poecilia formosa ENSPFOG00000015805 I 0.870
ENSPFOG00000019968 Poecilia formosa ENSPFOG00000019968 I 0.870
Pvit_10685 Pogona vitticeps Pvit_10685 I 0.914
Pvit_17282 Pogona vitticeps Pvit_17282 I 0.894
ENSPPYG00000011369 Pongo abelii ENSPPYG00000011369 I 0.914
ENSPPYG00000017041 Pongo abelii ENSPPYG00000017041 I 0.894
OLIG3 Procavia capensis ENSPCAG00000002488 I 0.894
OLIG2 Procavia capensis ENSPCAG00000005657 I 0.914
Olig2 Rattus norvegicus ENSRNOG00000028658 I 0.914
Olig3 Rattus norvegicus ENSRNOG00000012057 I 0.894
Sakowv30018772m.g Saccoglossus kowalevskii Sakowv30018772m.g I 0.847
ENSSHAG00000007183 Sarcophilus harrisii ENSSHAG00000007183 I 0.894
OLIG3 Sus scrofa ENSSSCG00000004155 I 0.894
OLIG3 Taeniopygia guttata ENSTGUG00000010892 I 0.894
olig2 Takifugu rubripes ENSTRUG00000014944 I 0.870
olig2 Tetraodon nigroviridis ENSTNIG00000000234 I 0.870
olig2 Tetraodon nigroviridis ENSTNIG00000003641 I 0.870
OLIG3 Tetraodon nigroviridis ENSTNIG00000017004 I 0.870
OLIG3 Tupaia belangeri ENSTBEG00000014468 I 0.894
olig3 Xenopus tropicalis XB-GENE-919789 I 0.894
XP_002938491 Xenopus tropicalis XP_002938491 I 0.890
ENSXMAG00000001116 Xiphophorus maculatus ENSXMAG00000001116 I 0.870
ENSXMAG00000018245 Xiphophorus maculatus ENSXMAG00000018245 I 0.894