MXD3 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000213347 T034345_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000389716 bHLH 58 110
ENSP00000401867 bHLH 58 110
ENSP00000416921 bHLH 58 110
ENSP00000421463 bHLH 58 110
ENSP00000425029 bHLH 51 100

Links

Other bHLH family TFs
Other Homo sapiens TFs

43 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
MXD3 Ochotona princeps ENSOPRG00000002125 N 0.914
ENSPANG00000007888 Papio anubis ENSPANG00000007888 N 0.914
MXD3 Oryctolagus cuniculus ENSOCUG00000022519 N 0.914
ENSOARG00000004235 Ovis aries ENSOARG00000004235 N 0.914
ENSMMUG00000009047 Macaca mulatta ENSMMUG00000009047 N 0.914
ENSNLEG00000012726 Nomascus leucogenys ENSNLEG00000012726 N 0.914
MXD3 Pan troglodytes ENSPTRG00000034491 N 0.914
MXD3 Pteropus vampyrus ENSPVAG00000003828 N 0.914
ENSMMUP00000033662 Macaca fascicularis ENSMMUP00000033662 N 0.914
ENSP00000389716-D1 Bos grunniens ENSP00000389716-D1 N 0.914
MXD3 Tursiops truncatus ENSTTRG00000009572 N 0.914
MXD3 Sus scrofa ENSSSCG00000014041 N 0.914
Rab24 Rattus norvegicus ENSRNOG00000016539 N 0.914
MXD3 Loxodonta africana ENSLAFG00000021836 N 0.914
Mxd3 Mus musculus ENSMUSG00000021485 N 0.914
MXD3 Equus caballus ENSECAG00000021155 N 0.914
MXD3 Echinops telfairi ENSETEG00000010972 N 0.914
ENSCSAG00000008875 Chlorocebus sabaeus ENSCSAG00000008875 N 0.914
ENSCJAG00000006943 Callithrix jacchus ENSCJAG00000006943 N 0.914
MXD3 Bos taurus ENSBTAG00000005010 N 0.914
MXD3 Erinaceus europaeus ENSEEUG00000015798 N 0.914
ENSGGOG00000011764 Gorilla gorilla ENSGGOG00000011764 N 0.914
Myotis_brandtii_MXD3_10032506 Myotis brandtii Myotis_brandtii_MXD3_10032506 N 0.894
MXD3 Dasypus novemcinctus ENSDNOG00000017403 N 0.894
ENSMLUG00000007019 Myotis lucifugus ENSMLUG00000007019 N 0.894
ENSAMEG00000018175 Ailuropoda melanoleuca ENSAMEG00000018175 N 0.893
ENSMPUG00000012200 Mustela putorius furo ENSMPUG00000012200 N 0.893
MXD3 Felis catus ENSFCAG00000001533 N 0.893
MXD3 Otolemur garnettii ENSOGAG00000032370 N 0.890
ENSSHAG00000013431 Sarcophilus harrisii ENSSHAG00000013431 N 0.889
ENSSTOG00000002697 Ictidomys tridecemlineatus ENSSTOG00000002697 N 0.888
MXD3 Canis familiaris ENSCAFG00000016437 N 0.880
MXD3 Monodelphis domestica ENSMODG00000004791 N 0.868
mxd3 Xenopus tropicalis XB-GENE-867571 N 0.860
mxd3.L Xenopus laevis XB-GENE-867580 N 0.860
ENSFALG00000000117 Ficedula albicollis ENSFALG00000000117 N 0.851
Aan_R001830 Calypte anna Aan_R001830 N 0.849
ENSSHAG00000011878 Sarcophilus harrisii ENSSHAG00000011878 N 0.840
MXD4 Oryctolagus cuniculus ENSOCUG00000005063 N 0.840
ENSMEUG00000013427 Macropus eugenii ENSMEUG00000013427 N 0.840
MXD4 Equus caballus ENSECAG00000002580 N 0.840
MXD4 Monodelphis domestica ENSMODG00000004033 N 0.840