Mlxipl (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000005373 T035659_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to DNA binding activity. Involved in glucose mediated signaling pathway; positive regulation of fatty acid biosynthetic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; gut; liver; metanephros; and nose. Used to study irritable bowel syndrome. Orthologous to human MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MLXIPL
M02772_2.00 		Homo sapiens
DNCACGTGHH
DDCACGTGNH		 SELEX
Jolma et al.(2013)
MLXIPL_1 		0.914 1.000
MLXIPL
M09788_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CHREBP_Q6 		0.914 1.000
MLXIPL
M09789_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CHREB_Q6_01 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000005507 bHLH 662 716
ENSMUSP00000116358 bHLH 14 68
ENSMUSP00000121348 bHLH 662 702
ENSMUSP00000121668 bHLH 21 115
ENSMUSP00000122198 bHLH 662 711

Links

Other bHLH family TFs
Other Mus musculus TFs

Invalid Input OrderBy

42 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action