TF Information

Tfap4 *(Mus musculus)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	ENSMUSG00000005718	T035660_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in cellular response to dexamethasone stimulus; negative regulation of macromolecule metabolic process; and protein-containing complex assembly. Acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and gut. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Tfap4 M01717_2.00	Mus musculus	VHCABVYGB	VCRBVTGDB	PBM Weirauch et al.(2014) pTH5067	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
TFAP4 M02776_2.00	Homo sapiens	AWCAGCTGWY	RWCAGCTGWT	SELEX Jolma et al.(2013) TFAP4_1	0.914	1.000
TFAP4 M02777_2.00	Homo sapiens	AWCAGCTGWT	AWCAGCTGWT	SELEX Jolma et al.(2013) TFAP4_2	0.914	1.000
TFAP4 M04066_2.00	Homo sapiens	VHCAKVTGDB	VHCABMTGDB	SELEX Yin et al.(2017) TFAP4_eDBD_HT-SELEX_1	0.914	1.000
TFAP4 M04067_2.00	Homo sapiens	VWCAGCTGWB	VWCAGCTGWB	SELEX Yin et al.(2017) TFAP4_eDBD_HT-SELEX_2	0.914	1.000
TFAP4 M04070_2.00	Homo sapiens	RHCAYVTGDB	VHCABRTGDY	SELEX Yin et al.(2017) TFAP4_FL_HT-SELEX_1	0.914	1.000
TFAP4 M04071_2.00	Homo sapiens	VHCAGCTGDB	VHCAGCTGDB	SELEX Yin et al.(2017) TFAP4_FL_HT-SELEX_2	0.914	1.000
TFAP4 M08712_2.00	Homo sapiens	VMNCAGCTGR	YCAGCTGNKB	Misc Kulakovskiy et al.(2013) TFAP4_HUMAN.H11MO.0.A	0.914	1.000
TFAP4 M09453_2.00	Homo sapiens	NVHCAGCTGD	HCAGCTGDBN	Misc Heinz et al.(2010) AML-Tfap4_GSE45738	0.914	1.000
TFAP4 M09802_2.00	Homo sapiens	MNGNCHVCAGCTGDBBBW	WVVVHCAGCTGBDGNCNK	Transfac Matys et al.(2006) V$AP4_01	0.914	1.000
TFAP4 M09803_2.00	Homo sapiens	NNSAGCTGHB	VDCAGCTSNN	Transfac Matys et al.(2006) V$AP4_Q5	0.914	1.000
TFAP4 M09804_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$AP4_Q6_01	0.914	1.000
TFAP4 M09805_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$AP4_Q6_02	0.914	1.000
TFAP4 M09806_2.00	Homo sapiens	NVCAGCTGHB	VDCAGCTGBN	Transfac Matys et al.(2006) V$AP4_Q6	0.914	1.000
TFAP4 M04068_2.00	Homo sapiens	DHCABMTGDN	NHCAKVTGDH	SELEX Yin et al.(2017) TFAP4_eDBD_Methyl-HT-SELEX_1	0.914	1.000
TFAP4 M04069_2.00	Homo sapiens	AWCAGCTGWT	AWCAGCTGWT	SELEX Yin et al.(2017) TFAP4_eDBD_Methyl-HT-SELEX_2	0.914	1.000
TFAP4 M04072_2.00	Homo sapiens	VHCABVTGDB	VHCABVTGDB	SELEX Yin et al.(2017) TFAP4_FL_Methyl-HT-SELEX_1	0.914	1.000
TFAP4 M04073_2.00	Homo sapiens	VHCAGCTGDB	VHCAGCTGDB	SELEX Yin et al.(2017) TFAP4_FL_Methyl-HT-SELEX_2	0.914	1.000
crp M03595_2.00	Drosophila melanogaster	AACAGCTGWT	AWCAGCTGTT	SELEX Nitta et al.(2015) crp_1	0.843	0.808
crp M05937_2.00	Drosophila melanogaster	VAHCAGCTGAY	RTCAGCTGDWB	B1H Zhu et al.(2011) crp_SANGER_10_FBgn0001994	0.843	0.808
For this family, TFs with SR scores > 0.838* will likely have a similar motif*