Ahr (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000019256 T035669_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Ahr
M08747_2.00
Mus musculus
DCACGCNMH

DKNGCGTGH
Misc
Kulakovskiy et al.(2013)
AHR_MOUSE.H11MO.0.B
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
AHR
M08716_2.00
Homo sapiens
DCACGCNMH

DKNGCGTGH
Misc
Kulakovskiy et al.(2013)
AHR_HUMAN.H11MO.0.B
0.914 1.000
AHR
M09816_2.00
Homo sapiens
WSTCACGCDASYYBGRRS

SYYCVRRSTHGCGTGASW
Transfac
Matys et al.(2006)
V$AHR_01
0.914 1.000
AHR
M09817_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AHR_Q5
0.914 1.000
AHR
M09818_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AHR_Q6_01
0.914 1.000
AHR
M09819_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AHR_Q6
0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000106434 bHLH 33 79
ENSMUSP00000112137 bHLH 34 79

Links

Other bHLH family TFs
Other Mus musculus TFs

57 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSPPYG00000017758 Pongo abelii ENSPPYG00000017758 I 0.914
AHR Pan troglodytes ENSPTRG00000018955 I 0.914
Ahr Rattus norvegicus ENSRNOG00000004342 I 0.914
ENSSARG00000001961 Sorex araneus ENSSARG00000001961 I 0.914
ENSPANG00000002444 Papio anubis ENSPANG00000002444 I 0.914
AHR Oryctolagus cuniculus ENSOCUG00000003877 I 0.914
ENSMPUG00000013964 Mustela putorius furo ENSMPUG00000013964 I 0.914
ENSOARG00000009234 Ovis aries ENSOARG00000009234 I 0.914
ENSSHAG00000001563 Sarcophilus harrisii ENSSHAG00000001563 I 0.914
ENSSSCG00000015364 Sus scrofa ENSSSCG00000015364 I 0.914
ENSVPAG00000008443 Vicugna pacos ENSVPAG00000008443 I 0.914
ENSP00000385642 Macaca fascicularis ENSP00000385642 I 0.914
Myotis_brandtii_AHR_10031750 Myotis brandtii Myotis_brandtii_AHR_10031750 I 0.914
ENSTTRG00000006913 Tursiops truncatus ENSTTRG00000006913 I 0.914
ENSTSYG00000010830 Tarsius syrichta ENSTSYG00000010830 I 0.914
AHR Sus scrofa ENSSSCG00000030484 I 0.914
ENSSTOG00000003086 Ictidomys tridecemlineatus ENSSTOG00000003086 I 0.914
ENSTBEG00000007210 Tupaia belangeri ENSTBEG00000007210 I 0.914
ENSMODG00000001528 Monodelphis domestica ENSMODG00000001528 I 0.914
ENSPCAG00000006894 Procavia capensis ENSPCAG00000006894 I 0.914
ENSMMUG00000012203 Macaca mulatta ENSMMUG00000012203 I 0.914
Ahr Dipodomys ordii ENSDORG00000007750 I 0.914
ENSETEG00000019660 Echinops telfairi ENSETEG00000019660 I 0.914
ENSCPOG00000005481 Cavia porcellus ENSCPOG00000005481 I 0.914
ENSCJAG00000001029 Callithrix jacchus ENSCJAG00000001029 I 0.914
ENSAMEG00000010559 Ailuropoda melanoleuca ENSAMEG00000010559 I 0.914
ENSCAFG00000002448 Canis familiaris ENSCAFG00000002448 I 0.914
AHR Homo sapiens ENSG00000106546 D 0.914
ENSCSAG00000013508 Chlorocebus sabaeus ENSCSAG00000013508 I 0.914
ENSLAFG00000015328 Loxodonta africana ENSLAFG00000015328 I 0.914
ENSLACG00000002803 Latimeria chalumnae ENSLACG00000002803 I 0.914
ENSMLUG00000000097 Myotis lucifugus ENSMLUG00000000097 I 0.914
ENSGGOG00000011367 Gorilla gorilla ENSGGOG00000011367 I 0.914
ENSPSIG00000010051 Pelodiscus sinensis ENSPSIG00000010051 I 0.894
ENSMGAG00000010174 Meleagris gallopavo ENSMGAG00000010174 I 0.894
Aan_R001040 Calypte anna Aan_R001040 I 0.894
Tal_R011867 Tyto alba Tal_R011867 I 0.894
Afo_R003471 Aptenodytes forsteri Afo_R003471 I 0.894
Gfo_R002789 Geospiza fortis Gfo_R002789 I 0.894
ENSAPLG00000008769 Anas platyrhynchos ENSAPLG00000008769 I 0.894
ENSGALG00000010836 Gallus gallus ENSGALG00000010836 I 0.894
ENSTGUG00000002585 Taeniopygia guttata ENSTGUG00000002585 I 0.894
ENSPVAG00000002167 Pteropus vampyrus ENSPVAG00000002167 I 0.886
ENSOGAG00000012656 Otolemur garnettii ENSOGAG00000012656 I 0.886
ENSDNOG00000003198 Dasypus novemcinctus ENSDNOG00000003198 I 0.886
ENSOPRG00000010358 Ochotona princeps ENSOPRG00000010358 I 0.882
ahr1b Gasterosteus aculeatus ENSGACG00000015615 I 0.881
SMU15033026 Schmidtea mediterranea SMU15033026 I 0.844
BGLB005801 Biomphalaria glabrata BGLB005801 I 0.844
PXEA_0000742401 Protopolystoma xenopodis PXEA_0000742401 I 0.844
CapteG145851 Capitella teleta CapteG145851 I 0.844
SMU15013078 Schmidtea mediterranea SMU15013078 I 0.844
CGI_10012885 Crassostrea gigas CGI_10012885 I 0.844
LotgiG117861 Lottia gigantea LotgiG117861 I 0.844
SPU_005022 Strongylocentrotus purpuratus SPU_005022 I 0.843
XP_002161735.1 Hydra magnipapillata XP_002161735.1 I 0.838