Hey2 (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000019789 T035670_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; regulation of gene expression; and umbilical cord morphogenesis. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; circulatory system development; and negative regulation of cardiac muscle cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study aortic valve disease and tetralogy of Fallot. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hey2
M01722_2.00		 Mus musculus
RCACGTGNN
NNCACGTGY		 PBM
Weirauch et al.(2014)
pTH5102		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HEY2
M02790_2.00 		Homo sapiens
GRCACGTGNV
BNCACGTGYC		 SELEX
Jolma et al.(2013)
HEY2_1 		0.914 1.000
HEY2
M02791_2.00 		Homo sapiens
GVCACGTGYN
NRCACGTGBC		 SELEX
Jolma et al.(2013)
HEY2_2 		0.914 1.000
HEY2
M04131_2.00 		Homo sapiens
NVCRCGYGVN
NBCRCGYGBN		 SELEX
Yin et al.(2017)
HEY2_eDBD_HT-SELEX 		0.914 1.000
HEY2
M04133_2.00 		Homo sapiens
NVCACGTGVN
NBCACGTGBN		 SELEX
Yin et al.(2017)
HEY2_FL_HT-SELEX 		0.914 1.000
HEY2
M04132_2.00 		Homo sapiens
NVCRCGYRVN
NBYRCGYGBN		 SELEX
Yin et al.(2017)
HEY2_eDBD_Methyl-HT-SELEX 		0.914 1.000
HEY2
M04134_2.00 		Homo sapiens
NVCRCGYGSN
NSCRCGYGBN		 SELEX
Yin et al.(2017)
HEY2_FL_Methyl-HT-SELEX 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01722_2.00 bHLH 13 68

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000019924 bHLH 49 104

Links

Other bHLH family TFs
Other Mus musculus TFs

Invalid Input OrderBy

163 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action