Hes7 (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000023781 T035683_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; post-anal tail morphogenesis; and somitogenesis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; retina; small intestine; unsegmented mesenchyme; and urinary system. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human HES7 (hes family bHLH transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hes7
M01727_2.00		 Mus musculus
NVCACGHGNN
NNCDCGTGBN		 PBM
Weirauch et al.(2014)
pTH5260		 (Direct) (Direct)
Hes7
M09887_2.00		 Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HES7_02		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HES7
M02802_2.00 		Homo sapiens
YGGCACGTGCCR
YGGCACGTGCCR		 SELEX
Jolma et al.(2013)
HES7_1 		0.914 1.000
HES7
M04191_2.00 		Homo sapiens
NVCRCGTGSC
GSCACGYGBN		 SELEX
Yin et al.(2017)
HES7_eDBD_HT-SELEX 		0.914 1.000
HES7
M04192_2.00 		Homo sapiens
NVCRCRTGVV
BBCAYGYGBN		 SELEX
Yin et al.(2017)
HES7_eDBD_Methyl-HT-SELEX 		0.914 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01727_2.00 bHLH 13 68

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000024543 bHLH 14 69

Links

Other bHLH family TFs
Other Mus musculus TFs

Invalid Input OrderBy

26 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action