CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Tfeb
(
Mus musculus
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSMUSG00000023990
T035684_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including defense response to Gram-negative bacterium; embryonic placenta development; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within lysosome organization and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and gut gland. Orthologous to human TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Tfeb
M01728_2.00
Mus musculus
CWCGTGAY
RTCACGWG
PBM
Weirauch et al.(2014)
pTH5072
(Direct)
(Direct)
Tfeb
M08753_2.00
Mus musculus
CACGTGAYY
RRTCACGTG
Misc
Kulakovskiy et al.(2013)
TFEB_MOUSE.H11MO.0.C
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
TFEB
M02781_2.00
Homo sapiens
RNCACGTGAY
RTCACGTGNY
SELEX
Jolma et al.(2013)
TFEB_1
0.914
1.000
TFEB
M02727_2.00
Homo sapiens
RTCACGTGAY
RTCACGTGAY
SELEX
Jolma et al.(2010)
TFEB_dimer
0.914
1.000
TFEB
M04088_2.00
Homo sapiens
YVCACGTGAYN
NRTCACGTGBR
SELEX
Yin et al.(2017)
TFEB_eDBD_HT-SELEX
0.914
1.000
TFEB
M08718_2.00
Homo sapiens
CACGTGAYY
RRTCACGTG
Misc
Kulakovskiy et al.(2013)
TFEB_HUMAN.H11MO.0.C
0.914
1.000
TFEB
M04089_2.00
Homo sapiens
VNCATGTGAYN
NRTCACATGNB
SELEX
Yin et al.(2017)
TFEB_eDBD_Methyl-HT-SELEX
0.914
1.000
Mitf
M01741_2.00
Mus musculus
NCDCGTGAYN
NRTCACGHGN
PBM
Weirauch et al.(2014)
pTH5465
0.855
0.889
MITF
M08058_2.00
Homo sapiens
NNNDRTCACGTGAYHNNN
NNNDRTCACGTGAYHNNN
ChIP-seq
Mathelier et al.(2014)
MA0620.2
0.855
0.889
MITF
M08740_2.00
Homo sapiens
YCAYGTGACH
DGTCACRTGR
Misc
Kulakovskiy et al.(2013)
MITF_HUMAN.H11MO.0.A
0.855
0.889
Mitf
M08765_2.00
Mus musculus
BCHYGTGACY
RGTCACRDGV
Misc
Kulakovskiy et al.(2013)
MITF_MOUSE.H11MO.0.A
0.855
0.889
Mitf
M09475_2.00
Mus musculus
GTCACRWGVB
VBCWYGTGAC
Misc
Heinz et al.(2010)
MastCells-MITF_GSE48085
0.855
0.889
MITF
M09880_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MITF_Q4
0.855
0.889
MITF
M09881_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$MITF_Q6
0.855
0.889
Tfe3
M01715_2.00
Mus musculus
NCDCRTGAYN
NRTCAYGHGN
PBM
Weirauch et al.(2014)
pTH5057
0.855
0.870
Tfe3
M05833_2.00
Mus musculus
CACGTGAY
RTCACGTG
SMiLE-seq
Isakova et al.(2017)
TFE3
0.855
0.870
Tfe3
M08743_2.00
Mus musculus
TCACGTGACH
DGTCACGTGA
Misc
Kulakovskiy et al.(2013)
TFE3_MOUSE.H11MO.0.A
0.855
0.870
Tfe3
M09884_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TFEA_01
0.855
0.870
For this family, TFs with SR scores >
0.838
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M01728_2.00
bHLH
11
64
KKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQ
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000024786
bHLH
294
347
KKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQ
ENSMUSP00000084151
bHLH
235
288
KKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQ
ENSMUSP00000108909
bHLH
235
266
KKDNHNLIERRRRFNINDRIKELGMLIPKAND
ENSMUSP00000108913
bHLH
235
288
KKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQ
ENSMUSP00000120311
bHLH
94
147
KKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQ
Links
Other
bHLH
family TFs
Other
Mus musculus
TFs
153 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy