Sohlh2 (Mus musculus)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSMUSG00000027794 T035692_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in oocyte differentiation; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Acts upstream of or within primary ovarian follicle growth and regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in early conceptus; eye; genitourinary system; heart; and liver. Orthologous to several human genes including CCDC169-SOHLH2 (CCDC169-SOHLH2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Sohlh2
M01733_2.00		 Mus musculus
NNHNCGTGVN
NBCACGNDNN		 PBM
Weirauch et al.(2014)
pTH5058		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Sohlh2
M09890_2.00 		Rattus norvegicus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEB1_01 		0.894 0.959
SOHLH2
M01113_2.00 		Homo sapiens
BCACGDRNN
NNYHCGTGV		 PBM
Lambert et al.(2019)
pTH11270 		0.849 0.857
SOHLH2
M04096_2.00 		Homo sapiens
NBCACGTGCN
NGCACGTGVN		 SELEX
Yin et al.(2017)
SOHLH2_eDBD_HT-SELEX 		0.849 0.857
SOHLH2
M04097_2.00 		Homo sapiens
NNMACGWDNN
NNHWCGTKNN		 SELEX
Yin et al.(2017)
SOHLH2_eDBD_Methyl-HT-SELEX 		0.849 0.857
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01733_2.00 bHLH 18 66

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000029369 bHLH 204 252

Links

Other bHLH family TFs
Other Mus musculus TFs

Invalid Input OrderBy

31 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action