CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Bhlhe41
(
Mus musculus
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSMUSG00000030256
T035703_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2014]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Bhlhe41
M01739_2.00
Mus musculus
NMNCGTGMN
NKCACGNKN
PBM
Weirauch et al.(2014)
pTH5060
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
BHLHE41
M02782_2.00
Homo sapiens
NKCACGTGMN
NKCACGTGMN
SELEX
Jolma et al.(2013)
BHLHB3_1
0.914
0.982
BHLHE41
M02783_2.00
Homo sapiens
RKCACGTGAY
RTCACGTGMY
SELEX
Jolma et al.(2013)
BHLHE41_1
0.914
0.982
BHLHE41
M04106_2.00
Homo sapiens
VTCACGTGAB
VTCACGTGAB
SELEX
Yin et al.(2017)
BHLHE41_eDBD_HT-SELEX
0.914
0.982
BHLHE41
M09833_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$DEC2_Q2
0.914
1.000
BHLHE41
M09834_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$DEC2_Q3
0.914
1.000
BHLHE41
M04107_2.00
Homo sapiens
RTCACGTGAY
RTCACGTGAY
SELEX
Yin et al.(2017)
BHLHE41_eDBD_Methyl-HT-SELEX
0.914
0.982
Bhlhe40
M00119_2.00
Mus musculus
DCACGTGMN
NKCACGTGH
PBM
Badis et al.(2009)
Bhlhb2_1274
0.914
0.964
Bhlhe40
M01738_2.00
Mus musculus
NCACRNBN
NVNYGTGN
PBM
Weirauch et al.(2014)
pTH4330
0.914
0.964
BHLHE40
M02788_2.00
Homo sapiens
NKCACGTGMH
DKCACGTGMN
SELEX
Jolma et al.(2013)
BHLHB2_1
0.914
0.964
Bhlhe40
M02817_2.00
Mus musculus
NKCACGTGMN
NKCACGTGMN
SELEX
Jolma et al.(2013)
Bhlhb2_1
0.914
0.964
Bhlhe40
M02818_2.00
Mus musculus
NKCACGTGMN
NKCACGTGMN
SELEX
Jolma et al.(2013)
Bhlhb2_2
0.914
0.964
BHLHE40
M04126_2.00
Homo sapiens
VTCACGTGAB
VTCACGTGAB
SELEX
Yin et al.(2017)
BHLHE40_eDBD_HT-SELEX
0.914
0.981
BHLHE40
M07798_2.00
Homo sapiens
DCACGTGMSN
NSKCACGTGH
ChIP-seq
Gerstein et al.(2012)
HepG2_BHLHE40_HudsonAlpha
0.914
0.981
BHLHE40
M08726_2.00
Homo sapiens
DDCACGTGMS
SKCACGTGHH
Misc
Kulakovskiy et al.(2013)
BHE40_HUMAN.H11MO.0.A
0.914
0.964
Bhlhe40
M08761_2.00
Mus musculus
DCACGTGMS
SKCACGTGH
Misc
Kulakovskiy et al.(2013)
BHE40_MOUSE.H11MO.0.A
0.914
0.964
BHLHE40
M09456_2.00
Homo sapiens
DCACGTGMNN
NNKCACGTGH
Misc
Heinz et al.(2010)
HepG2-BHLHE40_GSE31477
0.914
0.964
BHLHE40
M09842_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BHLHE40_03
0.914
0.964
BHLHE40
M09843_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$DEC1_Q2
0.914
0.964
BHLHE40
M09844_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$DEC1_Q3
0.914
0.964
BHLHE40
M09845_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STRA13_01
0.914
0.981
BHLHE40
M04127_2.00
Homo sapiens
RTCACGTGAY
RTCACGTGAY
SELEX
Yin et al.(2017)
BHLHE40_eDBD_Methyl-HT-SELEX
0.914
0.981
For this family, TFs with SR scores >
0.838
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M01739_2.00
bHLH
16
70
KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALT
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000032386
bHLH
46
100
KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALT
ENSMUSP00000107332
bHLH
45
100
YKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALT
Links
Other
bHLH
family TFs
Other
Mus musculus
TFs
118 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy